| 1 | Preliminary focus on the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles显示文摘In total knee arthroplasty(TKA)and total hip replacement(THR)the restoration of the normal joint function represents a fundamental feature.A prosthetic joint must be able to provide motions and to transmit functional loads.As reported in the literature,the stress distribution may be altered in bones after the implantation of a total joint prosthesis.Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component.Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections.Furthermore,nanoparticles with antimicrobial activity have been widely analysed.Accordingly,the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles.The obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial activity.However,critical aspects were found in the optimization of the nanocomposite bone cement. | T.Russo A.Gloria R.De Santis U.D'Amora G.Balato A.Vollaro O.Oliviero G.Improta M.Triassi L.Ambrosio | 2017 | Bioactive Materials2017，2，3： | 2 |
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