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| 1 | Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease显示文摘Background:The cardinal features of Parkinson’s disease(PD)are bradykinesia,rigidity and rest tremor.Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms.This study aims to characterize properties of oscillatory activity in the basal ganglia and motor thalamus in patients with PD.Methods:Twenty-nine patients with PD who underwent bilateral or unilateral electrode implantation for subthalamic nucleus(STN)DBS(n=11),unilateral pallidotomy(n=9)and unilateral thalamotomy(n=9)were studied.Microelectrode recordings in the STN,globus pallidus internus(GPi)and ventral oral posterior/ventral intermediate of thalamus(Vop/Vim)were performed.Electromyography of the contralateral limbs was recorded.Single unit characteristics including interspike intervals were analyzed.Spectral and coherence analyses were assessed.Mean spontaneous firing rate(MSFR)of neurons was calculated.Analysis of variance and χ^(2) test were performed.Results:Of 76 STN neurons,39.5% were 4–6 Hz band oscillatory neurons and 28.9% were β frequency band(βFB)oscillatory neurons.The MSFR was 44.2±7.6 Hz.Of 62 GPi neurons,37.1% were 4–6 Hz band oscillatory neurons and 27.4% were βFB neurons.The MSFR was 80.9±9.6 Hz.Of 44 Vop neurons,65.9% were 4–6 Hz band oscillatory neurons and 9%were βFB neurons.The MSFR was 24.4±4.2 Hz.Of 30 Vim oscillatory neurons,70% were 4–6 Hz band oscillatory neurons and 13.3% were β FB neurons.The MSFR was 30.3±3.6 Hz.Further analysis indicated that proportion of βFB oscillatory neurons in STN and GPi was higher than that of similar neurons in the Vop and Vim(P<0.05).Conversely,the proportion of 4–6 Hz band oscillatory neurons and tremor related neurons in the Vim and Vop was higher than that of STN and GPi(P<0.05).The highest MSFR was for GPi oscillatory neurons whereas the lowest MSFR was for Vop oscillatory neurons(P<0.005).Conclusion:The alterations in neuronal activity in basal ganglia play a critical role in generation of parkinsonism.β oscillatory activity is more prominent in basal ganglia than in thalamus suggesting that the activity likely results from dopaminergic depletion.While both basal ganglia and thalamus have tremor activity,the thalamus appears to play a more important role in tremor production,and basal ganglia β oscillatory activity might be the trigger. | G.Du P.Zhuang M.Hallett Y.-Q.Zhang J.-Y.Li Y.-J.Li | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 2 | 查看详情显示文摘 | T.Yin R.Wu Z.Leng G.Du X.Guo M.Zhang J.Zhang | | 0，，： | 1 |
| 3 | Protective effects of baicalin on ligature‐induced periodontitis in rats显示文摘 | X.Cai C.Li G.Du Z.Cao | 2007 | Journal of Periodontal Research2007，，1： | 1 |
| 4 | Impacts of the retinal environment and photoreceptor type on functional regeneration显示文摘Retinal regeneration is a promising central nervous system(CNS) target amongst the various stem cell therapy pursuits,due to its accessibility for manipulation and its disposition towards longitudinal monitoring of treatment safety and efficacy.We offer our perspective on current hurdles towards functional regeneration of cone photoreceptors.Cones are key:For patients suffering vision loss,cone photoreceptors are a required cellular component to restoring daytime vision,colour vision,and high acuity vision.The challenges of regenerating cones contrast with logistic challenges of regenerating rod photoreceptors,which underlines the importance of evaluating context in degeneration and regeneration studies.Foundational research is required to delineate the factors required to generate a diversity of cones in the human macula,and to coax both remaining and newly regenerating cones to rewire towards restoring daytime colour vision.A complex interplay between cell-intrinsic factors and the retinal environment determine both the specification of cone fates and the synaptic plasticity enabling their functional integration.Recent revelations that cellular materials are transferred amongst photoreceptor progenitors further emphasize the critical role of neighbouring cells in directing stem cell fates.From our vantage point,translation of stem cell therapies to restore the cone-rich human macula must be borne upon foundational research in cone-rich retinas.Research frameworks centered on patient outcomes should prioritize animal models and functional outputs that enable and report functional restoration of cone-mediated vision. | Michèle G.Du Val W.Ted Allison | 2017 | Neural Regeneration Research2017，12，3： | 0 |
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