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| 1 | Extracellular matrix-based intracortical microelectrodes:Toward a microfabricated neural interface based on natural materials显示文摘Extracellular matrix(ECM)-based implantable neural electrodes(NEs)were achieved using a microfabrication strategy on naturalsubstrate-based organic materials.The ECM-based design minimized the introduction of non-natural products into the brain.Further,it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions,thereby reducing inflammatory strain fields in the tissue.Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches.In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs. | Wen Shen Lohitash Karumbaiah Xi Liu Tarun Saxena Shuodan Chen Radhika Patkar Ravi V.Bellamkonda Mark G.Allen | 2015 | Microsystems & Nanoengineering2015，1，1： | 3 |
| 2 | Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces显示文摘Intracortical neural microelectrodes,which can directly interface with local neural microcircuits with high spatial and temporal resolution,are critical for neuroscience research,emerging clinical applications,and brain computer interfaces(BCI).However,clinical applications of these devices remain limited mostly by their inability to mitigate inflammatory reactions and support dense neuronal survival at their interfaces.Herein we report the development of microelectrodes primarily composed of extracellular matrix(ECM)proteins,which act as a bio-compatible and an electrochemical interface between the microelectrodes and physiological solution.These ECM-microelectrodes are batch fabricated using a novel combination of micro-transfer-molding and excimer laser micromachining to exhibit final dimensions comparable to those of commercial silicon-based microelectrodes.These are further integrated with a removable insertion stent which aids in intracortical implantation.Results from electrochemical models and in vivo recordings from the rat’s cortex indicate that ECM encapsulations have no significant effect on the electrochemical impedance characteristics of ECM-microelectrodes at neurologically relevant frequencies.ECM-microelectrodes are found to support a dense layer of neuronal somata and neurites on the electrode surface with high neuronal viability and exhibited markedly diminished neuroinflammation and glial scarring in early chronic experiments in rats. | Wen Shen Suradip Das Flavia Vitale Andrew Richardson Akshay Ananthakrishnan Laura A.Struzyna Daniel P.Brown Naixin Song Murari Ramkumar Timothy Lucas DKacy Cullen Brian Litt Mark G.Allen | 2018 | Microsystems & Nanoengineering2018，4，1： | 1 |
| 3 | Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37°C显示文摘 | Terence R.Moopanar David G.Allen | 2005 | The Journal of Physiology2005，，1： | 1 |
| 4 | Microfabricated microneedles: A novel approach to transdermal drug delivery显示文摘 | SebastienHenry Devin V.McAllister Mark G.Allen Mark R.Prausnitz | 2000 | J. Pharm. Sci2000，，8： | 1 |
| 5 | An implantable,wireless,battery-free system for tactile pressure sensing显示文摘The sense of touch is critical to dexterous use of the hands and thus an essential component of efforts to restore hand function after amputation or paralysis.Prosthetic systems have addressed this goal with wearable tactile sensors.However,such wearable sensors are suboptimal for neuroprosthetic systems designed to reanimate a patient’s own paralyzed hand.Here,we developed an implantable tactile sensing system intended for subdermal placement.The system is composed of a microfabricated capacitive pressure sensor,a custom integrated circuit supporting wireless powering and data transmission,and a laser-fused hermetic silica package.The miniature device was validated through simulations,benchtop assessment,and testing in a primate hand.The sensor implanted in the fingertip accurately measured applied skin forces with a resolution of 4.3 mN.The output from this novel sensor could be encoded in the brain with microstimulation to provide tactile feedback.More broadly,the materials,system design,and fabrication approach establish new foundational capabilities for various applications of implantable sensing systems. | Lin Du Han Hao Yixiao Ding Andrew Gabros Thomas C.E.Mier Jan Van der Spiegel Timothy H.Lucas Firooz Aflatouni Andrew G.Richardson Mark G.Allen | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 6 | Biodegradable magnesium/iron batteries with polycaprolactone encapsulation:A microfabricated power source for transient implantable devices显示文摘This study presents the design,fabrication,and testing of biodegradable magnesium/iron batteries featuring polycaprolactone(PCL)as a packaging and functional material.The use of PCL encapsulation minimized the electrochemical cell volume and supported longer discharge lifetimes and higher discharge rates than state-of-the-art biodegradable batteries.Specifically,the electrodes were separated and insulated by a 5μm-thick PCL layer that served as both a battery packaging material and a permeable coating for physiological solution to penetrate and activate the battery.A systematic investigation of the electrode size,discharge rates,electrolyte selection,and polymeric coating revealed the critical reactions and phenomena governing the performance of the Mg-based biodegradable batteries.Comparison with previous reports on biodegradable batteries and medicalgrade non-degradable lithium-ion batteries demonstrated the superior performance of PCL-coated Mg/Fe batteries at these size scales,which exhibited an energy density of 694 Wh kg^(−1) and a total volume of 0.02 cm^(3). | Melissa Tsang Andac Armutlulu Adam W.Martinez Sue Ann Bidstrup Allen Mark G.Allen | 2015 | Microsystems & Nanoengineering2015，1，1： | 0 |
| 7 | 直销到底是什么?显示文摘直销对许多人来说,光听这两个字,可能会激起许多不同的情绪.您也许喜欢直销,也许讨厌直销(有时候是又爱又恨),但是直销到底是什么呢? | Robert G.Allen | 2005 | 职业时空2005，，5： | 0 |
| 8 | A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection显示文摘Impedance-based protein detection sensors for point-of-care diagnostics require quantitative specificity,as well as rapid or real-time operation.Furthermore,microfabrication of these sensors can lead to the formation of factors suitable for in vivo operation.Herein,we present microfabricated needle-shaped microwell impedance sensors for rapid-sample-to-answer,label-free detection of cytokines,and other biomarkers.The microneedle form factor allows sensors to be utilized in transcutaneous or transvascular sensing applications.In vitro,experimental characterization confirmed sensor specificity and sensitivity to multiple proteins of interest.Mechanical characterization demonstrated sufficient microneedle robustness for transcutaneous insertion,as well as preserved sensor function postinsertion.We further utilized these sensors to carry out real-time in vivo quantification of human interleukin 8(hIL8)concentration levels in the blood of transgenic mice that endogenously express hIL8.To assess sensor functionality,hIL8 concentration levels in serum samples from the same mice were quantified by ELISA.Excellent agreement between real-time in vivo sensor readings in blood and subsequent ELISA serum assays was observed over multiple transgenic mice expressing hIL8 concentrations from 62 pg/mL to 539 ng/mL. | Naixin Song Pengfei Xie Wen Shen Hanju Oh Yejia Zhang Flavia Vitale Mehdi Javanmard Mark G.Allen | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
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