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| 1 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | Thymus and activation regulated chemokines in children with atopic dermatitis:Kyushu University Ishigaki Atopic Dermatitis Study (KIDS) 显示文摘 | Furusyo N Takeoka H Toyoda K | 2007 | Eur J Dermatol2007，17，5： | 1 |
| 3 | Double point mutation in the core promoter region of hepatitis B virus genotype C may be related to liver deterioration in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kubo N | 2004 | Gastroenterol Hepatol2004，19，5： | 1 |
| 4 | Clinical outcomes of hepatitis B virus (HBV) genotypes B and C in Japanese patients with chronic HBV infection显示文摘 | Furusyo N Nakashima H Kashiwagi K | 2002 | Am J Trop Med Hyg2002，67，2： | 1 |
| 5 | Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis显示文摘 | Yamano E Miyauchi M Furusyo H | 2010 | Laboratory Invest2010，98，8： | 1 |
| 6 | A case of granulomatosis with polyangiitis preceded by subacute thyroiditis显示文摘 | Mukae H Furusyo N Murata M | 2015 | Clin Case Rep2015，3，3： | 1 |
| 7 | Double point mutation in the core promoter region of hepatitis B virus genotype C may be related to liver deteriotation in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kube N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
| 8 | Association factors for atopic dermatitis in nursery school children in Ishigaki islands -Kyushu University Ishigaki Atopic Dermatitis Study (KIDS)显示文摘 | Fukiwake N Furusyo N Takeoka H | 2010 | Eur J Dermatol2010，18，5： | 1 |
| 9 | Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kubo N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
| 10 | Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kubo N | | 0，，05： | 1 |
| 11 | Double point mutation in the core prolnoter region of hepatitis B virus (HBV) genotypo C may be related to liver deterioration in patients with chronic HBV infection 显示文摘 | NAKASHINMA H FURUSYO N KUBO N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
| 12 | Glycated albumin as a diagnostictool for diabetes in a general Japanese population显示文摘 | Ikezaki H Furusyo N Ihara T | 2015 | Metabolism2015，64，6： | 1 |
| 13 | Inhibitory of orally adminis- trated liposomal bovine lactoferrin on the LPS-induced osteoclastoge- nesis 显示文摘 | Yamano E Miyauchi M Furusyo H | 2010 | Lab Invest2010，90，8： | 1 |
| 14 | TT-virus infection in Japanese general population and in hemodialysis patients显示文摘 | Kanamoto-Tanaka Y Furusyo N Nakashima H | 2002 | Dig Dis Sci2002，47，： | 1 |
| 15 | Inhibitory of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis 显示文摘 | Yamano E Miyauchi M Furusyo H | 2010 | Lab Invest2010，90，8： | 1 |
| 16 | Risk factors for peripheral arterial disease and its relationship to carotid atherosclerasis: the Kyushu and Okinawa Population study (KOPS) 显示文摘 | Ohnishi H Sawayama Y Furusyo N | 2010 | J Atheroseler Thromb2010，17，7： | 1 |
| 17 | Double point mutation in the core promoter region of hepatitis B virus genotype C may be related to liver deteriotation in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kube N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
| 18 | Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kubo N Kashiwagi K Etoh Y Kashiwagi S | 2004 | J Gastroenterol Hepatol2004，19，54： | 1 |
| 19 | Double point mutation in the core promoter region of hepatitis B virus genotype C may be related to liver deteriotation in patients with chronic HBV infection显示文摘 | Nakashima H Furusyo N Kube N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
| 20 | Double point mutation in the core pro-moter region of hepatitis B (HBV) genotype C may be related to liver deterioration in patients with chronic hepatitis B infection 显示文摘 | Nakashinma H Furusyo N Kubo N | 2004 | J Gastroenterol Hepatol2004，19，5： | 1 |
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