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| 1 | 肿瘤乏氧研究新进展显示文摘大量临床和实验动物研究表明乏氧见于90%以上的实体肿瘤,其生物等效致死剂量是富氧细胞的2-3倍;肿瘤治疗的总体疗效取决于肿瘤内乏氧细胞所占比例,因为乏氧细胞的存在明显增加了肿瘤对放疗、化疗的抗拒性和肿瘤自身的侵袭性,分子生物学研究已经基本明确了其作用机制[1-4]。而目前临床上应用的改善肿瘤内乏氧状态的手段,虽能提高某些肿瘤的疗效,但总体治疗效果无显著提高,有待进一步深入研究。随着分子影像技术的更新与完善,为肿瘤治疗的计划制定及预后评价提供了可靠依据。 | 文碧秀 王振宇 Fuqiu He | 2011 | 中华放射肿瘤学杂志2011，20，6： | 5 |
| 2 | X射线诱导γH2AX焦点形成的定量分析及其致DNA双链断裂的动态变化显示文摘目的 比较DNA依赖蛋白激酶催化亚基(DNA-PKcs^+/+)和DNA-PKcs^-/-小鼠胚胎成纤维细胞(MEF) X射线诱导γH2AX焦点形成的定量分析,并对鼻咽癌SUNE-1细胞进行X射线致DNA DSB动态变化。方法 采用蛋白印迹检测DNA-PKcs蛋白表达情况,细胞免疫荧光检测X射线5 Gy诱导的γH2AX焦点形成,通过ImageJ软件分析γH2AX焦点形成数量的差异。结果 DNA-PKcs在DNA-PKcs^-/-和DNA-PKcs^+/+ MEF细胞中分别表达缺失和正常。应用γH2AX焦点/细胞和γH2AX焦点/mm2分析方法动态分析X射线诱导的DNA-PKcs^+/+、DNA-PKcs^-/-MEF细胞和SUNE-1细胞DSB形成的总体趋势一致;照后 0.5~1.0 h大量γH2AX焦点形成,DNA-PKcs^+/+ MEF细胞于照后6.0 h完成修复,DNA-PKcs^-/-MEF和SUNE-1细胞X射线后于照后24.0 h完成修复。γH2AX焦点/细胞的峰值出现在照后1.0 h,γH2AX焦点/mm2的峰值则出现在照后0.5 h。对于DNA-PKcs^+/+和DNA-PKcs^-/-MEF细胞,γH2AX焦点/细胞在照后0.5、1.0、3.0、6.0、12.0 h的不同,而γH2AX焦点/mm2在照后3.0、6.0、12.0 h不同。结论 利用细胞免疫荧光动态检测照后致γH2AX焦点/细胞或γH2AX焦点/mm2的分析方法为动态定量研究DSB损伤及修复提供了新的思路。 | 董隽 王成涛 张纯 任玉峰 欧阳斌 张天 王振宇 Gloria C.Li Fuqiu He 文碧秀 | 2018 | 中华放射肿瘤学杂志2018，27，3： | 3 |
| 3 | Electrochemical extraction of cerium and formation of Al–Ce alloy from CeO_2 assisted by AlCl_3 in LiCl–KCl melts显示文摘This work presents an electrochemical extraction of cerium and synthesization of Al–Ce alloy in LiCl–KCl melts on Mo and Al electrodes by chlorination of CeO2 using AlCl3 at 873 K. The cyclic voltammogram on Mo electrodes in LiCl–KCl–CeO2 melt showed no obvious reduction wave other than the reduction of Li(I). After the addition of AlCl3, the signals of the reaction of Ce(ⅡI)/Ce(0) and the synthesization of Al–Ce and Al–Li alloys were investigated by cyclic voltammetry, square-wave voltammetry, open-circuit chronopotentiometry and chronopotentiometry. These results indicated that AlCl3 can chloridize CeO2 and that it is possible to extract cerium and form Al–Ce and Al–Li–Ce alloys in LiCl–KCl–CeO2–AlCl3 melts. According to potentiostatic electrolysis, only the Al4 Ce layer coated the Al electrodes. According to galvanostatic electrolysis, Al–Ce(Al4Ce, Al3 Ce, and Al92Ce8), Al2Li3, and Al phases were formed on Mo electrodes, and the content of cerium in the Al–Li–Ce alloys was more than 17 wt%. | ZHANG Meng WANG HaoYu HAN Wei ZHANG MiLin LI YunNa WANG YanLi XUE Yun MA FuQiu ZHANG XingMei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 4 | Enantioselective Transesterification of N-Hydroxymethyl Vince Lactam Catalyzed by Lipase under Ultrasound Irradiation 显示文摘 | LI Fuqiu ZHAO Dantong CHEN Ge | 2013 | Biocatalysis and Biotransformation2013，31，6： | 1 |
| 5 | Orthogonal testdesign for optimization of supercritical fluid extraction ofdaphnoretin 显示文摘 | Jinyong Penga Fuqiu Donga Qiwei Xua | 2006 | Journal of Chromatography A2006，1135，2： | 1 |
| 6 | Efficient bright γ-ray vortex emission from a laser-illuminated light-fan-in-channel target显示文摘X/γ-rays have many potential applications in laboratory astrophysics and particle physics.Although several methods have been proposed for generating electron,positron,and X/γ-photon beams with angular momentum(AM),the generation of ultra-intense brilliant γ-rays is still challenging.Here,we present an all-optical scheme to generate a high-energy γ-photon beam with large beam angular momentum(BAM),small divergence,and high brilliance.In the first stage,a circularly polarized laser pulse with intensity of 10^(22) W/cm^(2) irradiates a micro-channel target,drags out electrons from the channel wall,and accelerates them to high energies via the longitudinal electric fields.During the process,the laser transfers its spin angular momentum(SAM)to the electrons’orbital angular momentum(OAM).In the second stage,the drive pulse is reflected by the attached fan-foil and a vortex laser pulse is thus formed.In the third stage,the energetic electrons collide head-on with the reflected vortex pulse and transfer their AM to the γ-photons via nonlinear Compton scattering.Three-dimensional particle-in-cell simulations show that the peak brilliance of the γ-ray beam is∼10^(22) photons·s^(-1)·mm^(-2)·mrad^(-2) per 0.1% bandwidth at 1 MeV with a peak instantaneous power of 25 TW and averaged BAM of 10^(6)h/photon.The AM conversion efficiency from laser to the γ-photons is unprecedentedly 0.67%. | Hao Zhang Jie Zhao Yanting Hu Qianni Li Yu Lu Yue Cao Debin Zou Zhengming Sheng Francesco Pegoraro Paul McKenna Fuqiu Shao Tongpu Yu | 2021 | High Power Laser Science and Engineering2021，9，3： | 1 |
| 7 | Electrochemical properties of graphene nanosheet/carbon black composites as electrodes for supercapacitors显示文摘 | Jun Yan Tong Wei Bo Shao Fuqiu Ma Zhuangjun Fan Milin Zhang Chao Zheng Yongchen Shang Weizhong Qian Fei Wei | 2010 | Carbon2010，，6： | 1 |
| 8 | Laser chirp controlled relativistic few-cycle mid-infrared pulse generation显示文摘Relativistic few-cycle mid-infrared(mid-IR)pulses are unique tools for strong-field physics and ultrafast science,but are difficult to generate with traditional nonlinear optical methods.Here,we propose a scheme to generate such pulses with high efficiency via plasma-based frequency modulation with a negatively chirped laser pulse(NCLP).The NCLP is rapidly compressed longitudinally due to dispersion and plasma etching,and its central frequency is downshifted via photon deceleration due to the enhanced laser intensity and plasma density modulations.Simulation results show that few-cycle mid-IR pulses with the maximum center wavelength of 7.9µm and pulse intensity of a_(MIR)=2.9 can be generated under a proper chirp parameter.Further,the maximum energy conversion efficiency can approach 5.0%.Such a relativistic mid-IR source is promising for a wide range of applications. | Dongao Li Guobo Zhang Jie Zhao Yanting Hu Yu Lu Hao Zhang Qianni Li Dongze Zhang Rong Sha Fuqiu Shao Zhengming Sheng Tongpu Yu | 2023 | High Power Laser Science and Engineering2023，11，5： | 0 |
| 9 | Oscillatory stability of quantum droplets in PT-symmetric optical lattice显示文摘We study stability and collisions of quantum droplets(QDs)forming in a binary bosonic condensate trapped in parity-time(PT)-symmetric optical lattices.It is found that the stability of QDs in the PT-symmetric system depends strongly on the values of the imaginary part W0 of the PT-symmetric optical lattices,self-repulsion strength g,and the condensate norm N.As expected,the PT-symmetric QDs are entirely unstable in the broken PT-symmetric phase.However,the PT-symmetric QDs exhibit oscillatory stability with the increase of N and g in the unbroken PT-symmetric phase.Finally,collisions between PT-symmetric QDs are considered.The collisions of droplets with unequal norms are completely different from that in free space.Besides,a stable PT-symmetric QDs collides with an unstable ones tend to merge into breathers after the collision. | Jiehong Lao Zheng Zhou Xili Zhang Fuqiu Ye Honghua Zhong | 2021 | Communications in Theoretical Physics2021，73，6： | 0 |
| 10 | Study on Coordination of Amidoxime Small Molecule Ligand with Uranyl Ion under Seawater Condition显示文摘It has been found that uranium concentration in seawater is consistent in various locations around the world,even at depths up to 5 000 feet,at 3 parts per billion(ppb).With constant uranium concentration of 3ppb in a total of 1.3×1022 liters of seawater,the estimated amount of uranium is about 4billion tons in the ocean,and uranium exists mainly in U(Ⅵ)oxidation state as uranyl carbonates,about 98%. | LIU Tingting TIAN Guoxin YANG Suliang LIU Qian MA Fuqiu XUE Yun | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 11 | Development Status and Strategies of Xieka Cattle显示文摘In this paper,the present situation of Xieka cattle was investigated,and the body size of Xieka cattle was measured.It was found that there were some problems in Xieka cattle,such as backward feeding and management,and degradation of breeds.The corresponding strategies were put forward in order to promote the resource protection,development and utilization of Xieka cattle. | Yi SHI Donghui FANG Fang HE Fuqiu WU Jia GAN Yueda AGUO Xiaodong DENG Jun YI Maozhong FU Qi CAO Wei WANG | 2022 | Asian Agricultural Research2022，14，4： | 0 |
| 12 | Research on the Use of Synthetic Phonics in Primary School English Teaching显示文摘 | Chen Fuqiu | 2015 | 基础教育外语教学研究2015，，8： | 0 |
| 13 | Electroextraction of neodymium from LiCl-KCl melt using binary liquid Ga-Al cathode显示文摘The electrochemical behaviour of Nd(Ⅲ)ion was investigated on inert W,active Ga and Ga-AI cathodes.It is established that the reduction of Nd(Ⅲ)ion on the inert electrode is a consecutive two-step process while that on the active electrodes is a one-step process.The apparent standard potential of the Nd(Ⅲ)/Nd redox couple at different temperatures was determined by open-circuit chronopotentiometry and semi-differential method,and the relationship between temperature and apparent standard potential was further discussed.The thermodynamic properties of Nd in Ga and Ga-Al electrodes such as activity coefficient and activity were evaluated via intermittent coulomb titration and temperature dependence test,and the effect of temperature on activity coefficient was verified.Finally,Nd was successfully extracted in form of alloy from molten salt by galvanostatic electrolysis,in which the current efficiency of91.7%for the electroextraction indicates that the binary liquid Ga-Al electrode has favorable performance. | Li Ding Xuepeng Wang Yongde Yan Valeri Smolenski Wenda Xu Alena Novoselova Yun Xue Fuqiu Ma Xingmei Zhang | 2023 | Journal of Rare Earths2023，41，8： | 0 |
| 14 | A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen显示文摘Dear Editor,Catharanthus roseus,an important medicinal plant native to Madagascar,is the sole source of the two important anticancer drugs vinblastine and vincristine,which are synthesized by the monoterpene-derived indole alkaloid(MIA)pathway(Das et al.,2020).It is also an important model plant for the study of Huanglongbing(HLB),a devastating citrus disease that causes severe economic losses worldwide(Ma et al.,2022).Vincristine is an FDA-approved drug that has been used for acute lymphocytic leukemia,lymphoid blast crisis of chronic myeloid leukemia,and Hodgkin’s/non-Hodgkin’s lymphoma(Below and M Das,2021). | Zhongping Xu Guanying Wang Qiongqiong Wang Xiaoting Li Guangyu Zhang Ali Qurban Can Zhang Yi Zhou Huan Si Lisong Hu Fuqiu Wang Ying Wang Zhitao Tian Wei Chen Shuangxia Jin Fang Ding | 2023 | Plant Communications2023，4，6： | 0 |
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