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| 1 | Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease显示文摘AIM To determine the vaccination rates in pediatric immunosuppression-dependent inflammatory bowel disease(IBD) and review the safety and efficacy of vaccinations in this population.METHODS The electronic medical records from October 2009 to December 2015 of patients diagnosed with IBD at 10 years of age or younger and prescribed antitumor necrosis factor alpha(anti-TNF-α) therapy were reviewed for clinical history, medication history, vaccination history, and hepatitis B and varicella titers. Literature discussing vaccination response in IBD patients were identified through search of the MEDLINE database and reviewed using the key words 'inflammatory bowel disease', 'immunization', 'vaccination', 'pneumococcal', 'varicella', and 'hepatitis B'. Non-human and non-English language studies were excluded. Search results were reviewed by authors toselect articles that addressed safety and efficacy of immunizations in inflammatory bowel disease.RESULTS A total of 51 patients diagnosed with IBD prior to the age of 10 and receiving anti-TNF-α therapy were identified. Thirty-three percent of patients(17/51) had incomplete or no documentation of vaccinations. Sixteen case reports, cohort studies, cross-sectional studies, and randomized trials were determined through review of the literature to describe the safety and efficacy of hepatitis B, pneumococcal, and varicella immunizations in adult and pediatric patients with IBD. These studies showed that patients safely tolerated the vaccines without significant adverse effects. Importantly, IBD patients receiving immunosuppressive medications, particularly anti-TNF-α treatment, have decreased vaccine response compared to controls. However, the majority of patients are still able to achieve protective levels of specific antibodies. CONCLUSION Immunizations have been shown to be well-tolerated and protective immunity can be achieved in patients with IBD requiring immunosuppressive therapy. | Huyen-Tran Nguyen Phillip Minar Kimberly Jackson Patricia C Fulkerson | 2017 | World Journal of Gastroenterology2017,23,42: | 2 |
| 2 | Fixation of periprosthetic femoral shaft fractures associated with cemented femo- ral stems: a biomechanical comparison of locked plating and conven- tional cable plates显示文摘 | FULKERSON E KOVAL K PRESTON C F | 2006 | J Orthop Trauma2006,20,2: | 1 |
| 3 | Building a better mouse model:experimental models of chronic asthma显示文摘 | Fulkerson P C Rothenberg M E Hogan S P | 2005 | Clin Exp Allergy2005,35,10: | 1 |
| 4 | Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling 显示文摘 | Fulkerson P C Fischetti C A Rothenberg M E | 2006 | Am J Pathol2006,169,6: | 1 |
| 5 | Degradation kinetics of leaves and stems of forage rape(Brassiea napus)as affected by maturity显示文摘 | Kaur R Garcia S C Fulkerson W J et ol | 2011 | Anita Feed Sci Technol2011,168,34: | 1 |
| 6 | Antibiotic susceptibility of bacteria infecting total joint arthroplasty sites 显示文摘 | Fulkerson E Valle C J Wise B | 2006 | J Bone Joint Surg Am2006,88,: | 1 |
| 7 | Database Security:Controlling Access to Your Most Valuable Information Asset显示文摘 | Fulkerson C Gonsoulin M Walz D | 2002 | Strategic Finance2002,84,12: | 1 |
| 8 | Maximizing the minimum sourcesink path subject to a budget constraint显示文摘 | Fulkerson D R Harding G C | 1977 | Mathematical Programming1977,13,: | 1 |
| 9 | Database Security: Controlling Access(On Your Most Valuable Information Asset显示文摘 | Fulkerson C Gonsoulin M Walz D | 2002 | Strategic Finance2002,84,12: | 1 |
| 10 | N Novel targeted therapies for eosinophilic disorders 显示文摘 | Wechsler M E Fulkerson P C Bochner B S | 2012 | J Allergy Clin Immunol2012,130,3: | 1 |
| 11 | Osteotomy about the knee: application,technique, and result显示文摘 | Preston C F Fulkerson R Meislin R | 2005 | J Knee Surg2005,18,4: | 1 |
| 12 | A comparison of three techniques to determine the herbage intake of dairy cows grazing kikuyu (Pennisetum clandestinum) pasture 显示文摘 | Reeves M Fulkerson W J Kellaway R C | 1996 | Australian Journal of Experimental Agriculture1996,36,: | 1 |
| 13 | Degradation kinetics of leaves and stems of (orage rape(Brassica napus)as affected by maturity 显示文摘 | Kaur R Garcia S C Fulkerson W J | 2011 | Animal Feed Science and Technology2011,168,16: | 1 |
| 14 | Degradation kinet- ics of leaves, petioles and stems of forage rape ( Brassica napus) as affected by maturity 显示文摘 | Kaur R Garcia S C Fulkerson W J | 2011 | Animal Feed Science and Technology2011,,168: | 1 |
| 15 | Targeting eosinophils in allergy, in- flammation and beyond 显示文摘 | Fulkerson P C Rothenberg M E | 2013 | Nat Rev Drug Discov2013,12,2: | 1 |
| 16 | Analysis of the potential risk of central intravenous lines and/or total parenteral nutrition with ventriculoatrial shunts显示文摘 | White I K Shaikh K A Nyarenchi O M Kundu M G Boaz J C Fulkerson D H | 2015 | Childs Nerv Syst2015,31,: | 1 |
| 17 | Osteotomy about the knee : application, technique, and result 显示文摘 | Preston C F Fulkerson R Meislin R | 2005 | J Knee Surg2005,18,4: | 1 |
| 18 | A central regulatory role for eosinophils and the Eotaxin/CCR3 axis in chronic experimental aller gic airway inflammation显示文摘 | FULKERSON P C FISCHETTI C A MCBRIDE M L | 2006 | Proc Nat Acad Sci U S A2006,133,: | 1 |
| 19 | Children presenting with ealeified disc herniation: a self-limiting process 显示文摘 | Ho C Chang S Fulkerson D | 2012 | J Radiol Case Rep2012,6,10: | 1 |
| 20 | IL-5 triggers acooperative cytokine network that promotes eosinophil precursormaturation显示文摘 | Fulkerson PC Schollaert KL Bouffi C | 2014 | J Immunol2014,193,8: | 1 |