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| 1 | Relationship between therapeutic efficacy of arterial infusion chemotherapy and expression of P-glycoprotein and p53 protein in advanced hepatocellular carcinoma显示文摘瞄准:在先进肝细胞癌(HCC ) 调查在化学疗法的药功效和 P-glycoprotein (PGP ) 和 p53 蛋白质的表示之间的关系。方法:学习在 41 上被进行被对待由的有先进 HCC 的病人重复了动脉的注入化疗。从肿瘤的活体检视标本在所有病人在治疗的开始前被收集,并且标本被存储结冰直到免疫,到组织化学的染色,它在治疗的开始以后被执行检测 PGP 和 p53 蛋白质表情。41 个病人中的二十个与 anthracycline 药被对待(epirubicin 水疗院氯化物;anthracycline 组) ,并且留下 21 与 non-anthracycline 药被对待(在 11 个病人的 mitoxantrone 水疗院氯化物和在 10 个病人的 carboplatin;non-anthracycline 组) 。在化学疗法的功效和染色的免疫的结果之间的关系在二个组之间被比较。结果:在治疗的开始前, PGP 积极的率是 90.2%( 强烈积极, 36.6%) 并且蛋白质积极的率是的 p53 34.1%( 强烈积极, 19.5%) 。在 anthracycline 组,反应率是 40.0% 。显示出差的反应到治疗的病人的数字在有强烈积极的 PGP 表示(P=0.005 ) 的病人是显著地更大的,并且他们的预测是穷人(P=0.001 ) 。在 non-anthracycline 组,反应率是 42.9% ,并且在化学疗法的药功效和 PGP 或 p53 蛋白质表示之间没有重要关系。当仅仅从 11 个病人的数据与蒽醌对待药时, mitoxantrone,然而,被分析显示出差的反应到治疗的病人的数字在 p53 积极的病人(P=0.012 ) 之中是显著地更高的,不管幸存结果。结论:有为先进 HCC 的 anthracycline 药的化学疗法的功效能被免疫预言 PGP 的组织化学的分析表示。同样,染色评估 p53 蛋白质的免疫可能是有用的在与蒽醌药对待的病人预言反应。 | MasahideAkimoto MasaharuYoshikawa MasaakiEbara TsunenobuSato HiroyukiFukuda HiromitsuSaisho Fukuo Kondo | 2006 | World Journal of Gastroenterology2006，12，6： | 7 |
| 2 | Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis显示文摘Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis.We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis.A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts,diffuse thickening of the wall of the extrahepatic bile duct,and thickening of the gallbladder wall.Under the diagnosis of lower bile duct carcinoma,he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination,conspicuous fibrosis was seen in the lower bile duct wall.In the gallbladder wall,marked eosinophilic infiltration was seen.Liver biopsy revealed mild portal fibrosis.He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology.The possible etiology of sclerosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct.The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis(PSC).Bile duct wall thickening in patientswith eosinophilic cholangitis might be due to fibrosis of the bile duct wall.Eosinophilic cholangiopathy might be confused as PSC with eosinophilia. | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 3 | Expression of Transcription Factor E2F-1 in Pancreatic Ductal Carcinoma: An Immunohistochemical Study显示文摘 | Kazuto Yamazaki Takayuki Yajima Toshitaka Nagao Hiroki Shinkawa Fukuo Kondo Kyota Hanami Akira Asoh Isamu Sugano Yasuo Ishida | 2003 | Pathology - Research and Practice2003，，1： | 1 |
| 4 | The response of composite joints with bolt - lamping loads 显示文摘 | Sun H T Chang Fukuo Qing Xinlin | 2002 | Journal of Composite Materials2002，36，1： | 1 |
| 5 | Possible participation of Fas-mediated apoptosis in the mechanism of atherosclerosis显示文摘 | Fukuo K Nakahashi T Nomura S | 1997 | Gerontology1997，431，： | 1 |
| 6 | Nitric oxide induces upregulation of fas and apoptosis in vascular smooth muscle显示文摘 | Hata S Suhara T | 1996 | Hypertension1996，27，32： | 1 |
| 7 | Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle显示文摘 | Fukuo K Hata S Suhara T | | 0，，： | 1 |
| 8 | Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients显示文摘 | Okaishi K Morimoto S Fukuo K | 1999 | Am J Hypertens1999，12，8： | 1 |
| 9 | Development of a differential optical-fiber displacement sensor 显示文摘 | Fukuo Suganuma Atsushi Shimamoto Kohichi Tanaka | 1999 | Applied Optics1999，38，7： | 1 |
| 10 | Nitric oxide induces upredulation of Fas and apoptosis in vascular smooth muscle 显示文摘 | Fukuo K Hata S Suhara T | 1996 | Hypertension1996，27，32： | 1 |
| 11 | Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthas expression显示文摘 | Takemura Y Fukuo K Yasuda O | 2004 | Hypertension2004，43，2： | 1 |
| 12 | Nitric oxide induces upregulation of fas antigenand apoptosis in vascular smooth muscle cells显示文摘 | Fukuo K Hata S Suhara T | 1996 | Hypertension1996，27，： | 1 |
| 13 | Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways显示文摘 | Suhara T Fukuo K Yasuda O | 2004 | Hypertension2004，43，6： | 1 |
| 14 | Apoptosis signal-regulating kinase 1 mediates cellular senes- cence induced by high glucose in endothelial cells 显示文摘 | Yokoi T Fukuo K Yasuda O | 2006 | Diabetes2006，55，6： | 1 |
| 15 | Pitch-catch active sensing methods in structural health monitoring for aircraft structures显示文摘 | IHN J B CHANG Fukuo | 2008 | Structural Health Monitoring2008，7，5： | 1 |
| 16 | A poptesis signal-regulating kinase 1 mediates celhlar senescence induced by high glucose in endothelial cells显示文摘 | Yokol T Fukuo K Yasu O | | 0，，： | 1 |
| 17 | Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease 显示文摘 | Fukuo Y Yamashina S Sonoue H | 2014 | Hepatol Res2014，44，9： | 1 |
| 18 | Debond detection using embedded piezoelectric elements in reinforced concrete structures-Part Ⅰ: Experiment 显示文摘 | Wu Fan Chang Fukuo | 2006 | Structural Health Monitoring2006，5，1： | 1 |
| 19 | Hydrogen peroxide induces up-regulation of Fas in human endothelial cells 显示文摘 | Suhara T Fukuo K Sugimoto T | 1998 | J Immunol1998，160，8： | 1 |
| 20 | Homocysteine enhances endothelial apoptosis via upregulation of Fasmediated pathways显示文摘 | Suhara T Fukuo K Yasuda O | 2014 | Hypertension2014，43，6： | 1 |
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