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| 1 | Analysis of characteristics and predictive factors of immune checkpoint inhibitor-related adverse events显示文摘Objective:We aimed to retrospectively analyze the toxicity profiles and predictors of immune-related adverse events(irAEs)as well as the correlation between irAEs and the clinical efficacy of multi-type immune checkpoint inhibitors(ICIs)in patients with advanced pan-cancer in a real-world setting.Methods:We retrospectively analyzed data from 105 patients with advanced pan-cancer treated with multi-type ICIs at the First Hospital of Jilin University between January 1,2016 and August 1,2020.We used logistic regression analyses to investigate the associations of irAEs with clinical baseline characteristics,blood count parameters,and biochemical indicators during treatment.Receiver operating characteristic curves were used to determine cutoff values for parameters and area under the curve values.Kaplan–Meier and Cox multivariate regression analyses were performed to estimate the relationships of baseline characteristics and irAEs with progression-free survival(PFS)and overall survival(OS).Results:A lower relative lymphocyte count(cutoff=28.5%),higher albumin level(cutoff=39.05 g/L),and higher absolute eosinophil count(AEC)(cutoff=0.175×10^(9)/L)were significantly associated with the occurrence of irAEs,among which a higher AEC(cutoff=0.205×10^(9)/L)was strongly associated with skin-related irAEs[odds ratios(ORs)=0.163,P=0.004].Moreover,a higher lactate dehydrogenase level(cutoff=237.5 U/L)was an independent predictor of irAEs of grade≥3(OR=0.083,P=0.023).In immune cell subgroup analysis,a lower absolute count of CD8+CD28−suppressor T cells(OR=0.806;95%confidence interval:0.643–1.011;P=0.062),which are regulatory T lymphocytes,was associated with the occurrence of irAEs,although the difference was not statistically significant.Furthermore,a higher percentage of CD19+B cells was associated with the occurrence of irAEs of grade≥3(P=0.02)and grade≥2(P=0.051).In addition,patients with any grade of irAE had a significantly high PFS(8.37 vs.3.77 months,hazard ratios(HR)=2.02,P=0.0038)and OS(24.77 vs.13.83 months,HR=1.84;P=0.024).Conclusions:This retrospective study reports clinical profile data for irAEs in unselected patients in a real-world setting and explored some parameters that may be potential predictive markers of the occurrence,type,or grade of irAEs in clinical practice.Evidence of a correlation between safety and efficacy may facilitate a complete assessment of the risk-benefit ratio for patients treated with ICIs. | Rilan Bai Naifei Chen Xiao Chen Lingyu Li Wei Song Wei Li Yuguang Zhao Yongfei Zhang Fujun Han Zheng Lyu Jiuwei Cui | 2021 | Cancer Biology & Medicine2021，18，4： | 4 |
| 2 | Simultaneous bottom-up double-layer synergistic engineering by multifunctional natural molecules for efficient and stable SnO2-based planar perovskite solar cells显示文摘The performance and stability of perovskite solar cells(PSCs)is limited by detrimental defects,mostly distributed at the grain boundary(GB)of bulk perovskite film and interface,which induce serious carrier non-radiative recombination.Therefore,there is particularly urgent to realize simultaneous passivation of bulk defects and interfacial defects.In this work,a simple,low-cost and effective multifunctional modification strategy is developed by introducing theλ-Carrageenan(λ-C)as the interfacial layer of SnO_(2)/perovskite.The sulfate groups ofλ-C not only play a positive role in passivating the Sn4+from SnO_(2)film,resulting in high conductivity,but also effectively passivate the defects at the SnO_(2)/perovskite interface.Meanwhile,λ-C can effectively passivate the defects in the perovskite film due to the strong binding force between the high content of sulfate groups and PbI2.The synergistic effect ofλ-C simultaneously achieves interfacial defects and bulk defects passivation,better crystalline quality,suppressed charge recombination,released interfacial stress and more favorable interfacial energy level alignment.Based on the above efficient synergy,theλ-C-modified device achieves a high efficiency of 23.81%,which is~24.53%higher than the control device(19.12%).To our best knowledge,23.81%of power conversion efficiency(PCE)is the highest reported PCE value of PSCs employing green natural additives.Moreover,long-term and thermal stabilities are significantly improved after interface modification.Thus,this work provides an idea for developing multifunctional natural materials towards the attainment of the efficient and stable PSCs. | Yue Liu Yanbo Gao Tingting Li Xinyu Bao Zehua Xu Fujun Zhang Min Lu Zhennan Wu Yanjie Wu Guang Sun Xue Bai Zhifeng Shi Junhua Hu Yu Zhang | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 3 | Hf_(0.5)Zr_(0.5)O_(2)1T–1C FeRAM arrays with excellent endurance performance for embedded memory显示文摘Since the initial report of HfO2-based ferroelectric films in 2011,great attention has been paid to ferroelectric field-effect transistors and ferroelectric random-access memories(FeRAMs)[1–3].Up to now,many efforts have been devoted to realizing the industrialization of HfO2-based FE films.However,the limited fatigue performance has always been the main problem to be resolved. | Wenwu XIAO Yue PENG Yan LIU Huifu DUAN Fujun BAI Bing YU Qiwei REN Xiao YU Genquan HAN | 2023 | Science China(Information Sciences)2023，66，4： | 0 |
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