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| 1 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 2 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 3 | Extremely high multiplicities in high-energy nucleus-nucleus collisions显示文摘 | Burnett T H Dake S Fuki M | 1983 | Phys Rev Lett1983，50，26： | 1 |
| 4 | Case of adult genotype C HBV carrier after acute hepatitis B,losing HBsAg and acquiring HBsAb after IFN and lamivudine treatment显示文摘 | Kim SR Imoto S Fuki S | 2006 | Hepatol Res2006，36，2： | 1 |
| 5 | Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglyean-mediated pathway显示文摘 | Fuki IV Blanchard N Jin WJ | 2003 | J Biol Chem2003，278，34： | 1 |
| 6 | Angiotensin II Type 1 Receptor Blocker Reduces Monocyte Adhesion to Endothelial Cells in spontaneously hypertens- ive rats 显示文摘 | Fuki I Kosuke A | 2007 | Endocrine Journal2007，54，4： | 1 |
| 7 | Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan mediated pathway显示文摘 | Fuki Ⅳ Blanchard N Jin WJ | 2003 | J Biol Chem2003，278，34： | 1 |
| 8 | Both the peroxisome proliferator-activated receptor delta agonist, GW0742, andezetimibe promote reverse cholesterol transport in mice by reducing intestinal reabsorption of HDL-derived cholesterol 显示文摘 | Briand F Naik SU Fuki I | 2009 | Clin Transl Sci2009，2，2： | 1 |
| 9 | Role of N-linked glycosylation in the secretion and activity of endothelial lipase显示文摘 | Miller G C Long C J Bojilova E D Marchadier D Badellino K 0 Blanchard N Fuki I V Glick J M Rader D J | 2004 | Journal of Lipid Research2004，45，11： | 1 |
| 10 | Matutation of ovarian activity follicalar size and the presence or absence of cumulus cells显示文摘 | FUKI Y SHAKUMA Y | 1980 | Biol Reprod1980，，22： | 1 |
| 11 | Guidelines for the diagnosis andtreatment of spontaneous : occlusion of the circleof Willis(Moyamoya disease)显示文摘 | Fuki M | 1997 | Clin NeurolNeurosurg1997，99，： | 1 |
| 12 | Blanchances binding and cellularprocessing of plasma lipoproteins via HSPG-mediated pathway 显示文摘 | Fuki IV | 2003 | J Biol Chem2003，278，34： | 1 |
| 13 | Extremely high multiplicities in high-energy nucleus-nucleus collisions显示文摘 | BURNETT T H DAKE S FUKI M | 1983 | Phys Rev Lett1983，50，26： | 1 |
| 14 | Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway显示文摘 | Fuki IV Blanchard N Jin W | | 0，，36： | 1 |
| 15 | Antimitogenic effects of HDL and apoE mediated by Cox-2-dependent IP activation显示文摘 | Kothapalii D Fuki I Ali K | 2004 | J Clin Invest2004，113，： | 1 |
| 16 | Endoihelial lipase is less effec- tive at influencing HDL metabolism in vivo in mice expressing apoA-II显示文摘 | Broedl UC Jin W Fuki IV | 2006 | Lipid Res2006，47，： | 1 |
| 17 | Anterior segment optical coherence tomography findings of reverse pupillary block after scleral-fixated sutured posterior chamber intraocular lens implantation 显示文摘 | TOMOMI H FUKI S AKIRA N | 2009 | J Cataract Refract Surg2009，35，9： | 1 |
| 18 | Transmembrane and cytoplasmic do- mains of syndecan mediate a multi-step endocytic pathway involving de- tergent-insoluble membrane rafts显示文摘 | Fuki IV Meyer ME Williams KJ | 2000 | Biochem J2000，351，： | 1 |
| 19 | Endogenously produced endolhelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway 显示文摘 | Fuki IV Blanchard N Jin W J | 2003 | J Biol Chem2003，278，34： | 1 |
| 20 | SrTiO3-Based Boundary-Layer Capacitor Having Varistor Characteristics 显示文摘 | Yamaoka N Masuyama M Fuki M | 1983 | American Ceramic Society Bulletin1983，62，6： | 1 |
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