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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | A one-regular graph of degree three显示文摘 | FRUCHT R | 1952 | Can J Math1952，4，3： | 1 |
| 3 | Labelling Prisms 显示文摘 | FRUCHT R W GALLIAN J A | 1988 | Ars Combin1988，26，： | 1 |
| 4 | The genetics of colorectal cancer显示文摘 | Calvert PM Frucht H | 2002 | Ann Intern Med2002，137，7： | 1 |
| 5 | Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells显示文摘 | Yang WL Frucht H | 2001 | Carcinogenesis2001，22，9： | 1 |
| 6 | AP17 and AP19, the Mammalian Small Chains of the Clathrin- Associated Protein Complexes Show Homology to Yap17p, Their Putative Homolog in Yeast 显示文摘 | KIRCHHAUSEN T DAVIS A C FRUCHT S | 1991 | J Biol Chem1991，266，11： | 1 |
| 7 | Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole显示文摘 | Frucht S Rogers JD Greene PE | 1999 | Neurology1999，52，9： | 1 |
| 8 | 显示文摘 | Lighvani AA Frucht M Jankovic D | 2001 | Proc Natl Acad Sci USA2001，98，15： | 1 |
| 9 | Dystonia, athetosis, and epilepsia partialis continua in a patient with late-onset Rasmussen' s encephalitis 显示文摘 | Frucht S | 2002 | Mov Disord2002，17，3： | 1 |
| 10 | Nearly graceful labelings of graphs显示文摘 | FRUCHT R | 1992 | Scientia1992，5，： | 1 |
| 11 | On the Corona of Two Graphs显示文摘 | Frucht R Harary F | 1970 | Aequationes Mathematicae1970，4，3： | 1 |
| 12 | The genetics of colorectal cancer显示文摘 | Calvert PM Frucht H | 2002 | Ann Intern Med2002，137，7： | 1 |
| 13 | Characterization and analysis of the proximal Janus kinase 3 promoter 显示文摘 | Aringer M Hofmann SR Frucht DM | 2003 | J Immunol2003，170，12： | 1 |
| 14 | Graceful numbering of wheel and related graphs 显示文摘 | Frucht R | 1979 | Ann N Y Acad Sci1979，，319： | 1 |
| 15 | Unexpected and variable phenntypes in a family with JAK3 deficiency显示文摘 | Frucht DM Gadina M Jagadeesh GJ | 2001 | Genes and Immunity2001，2，： | 1 |
| 16 | Graceful numbering of snakes with constraints on the frst label显示文摘 | FRUCHT R SALINAS L C | 1985 | Ars Combin1985，，： | 1 |
| 17 | A unique role for IL-23 in promoting cellular immunity显示文摘 | Lankford CS Frucht DM | 2003 | J Leukoc Biol2003，73，1： | 1 |
| 18 | The natural history and treatment of acquired hemidystonia: report of 33 cases and review of the literature显示文摘 | Chuang C Fahn S Frucht SJ | 2002 | J Neurol Neurosurg Psychiat2002，72，1： | 1 |
| 19 | The genetics of colorectal cancer显示文摘 | Calvert PM Frucht H | 2002 | Ann Intern Med2002，137，7： | 1 |
| 20 | Proc T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells 显示文摘 | Lighvani AA Frucht DM Jankvic D | 2001 | Natl Acad Sci USA2001，98，15： | 1 |
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