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| 1 | Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral显示文摘Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these tissues.To address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological properties.The bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM.The time for solidification and the degradation properties were subsequently recorded.Scanning electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each block.The bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to degradation.SEM and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time PCR.PRF bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used alone.Future clinical studies are warranted to further support the clinical application of PRF bone blocks in bone regeneration procedures. | Mengge Feng Yulan Wang Yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong Masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang | 2022 | Fundamental Research2022，2，2： | 3 |
| 2 | Comparison of bioactive glass synthetic bone graft paricles and open debrclement in the treatment of human periodontal defects:A clinical study显示文摘 | Weinberg MA Tarnow D | 1998 | J Periodont1998，69，6： | 1 |
| 3 | Effect of platelet-rich plasma on bone growth and Osseo integration in human maxillary sinus grafts:three bilateral case reports显示文摘 | Wallace SS Tarnow DP | 2002 | Int J Periodontics Restorative Dent2002，22，1： | 1 |
| 4 | Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts:three bilateral case reports显示文摘 | Froum SJ Wallace SS Tarnow DP | 2002 | Int J Periodontics Restorative Dent2002，22，1： | 1 |
| 5 | The Use of CO2 Laser in the Treatment of Peri-implantitis显示文摘 | George Romanos Hua-Hsin Ko Stuart Froum | 2009 | Photomedicine and Laser Surgery2009，27，3： | 1 |
| 6 | A retrospective study of 1925 consecu- tively placed immediate implants from 1988 to 2004 显示文摘 | Wagenberg B Froum SJ | 2006 | Int J Oral Maxillofac Implants2006，21，1： | 1 |
| 7 | Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio-Oss) for sinus augmentation显示文摘 | Froum SJ Wallace SS Elian N | 2006 | Int J Periodontics Restorative Dent2006，26，6： | 1 |
| 8 | Schneiderian membrane perforation rate during sinus elevation using piezosurgery:clinical results of 100 consecutive cases显示文摘 | Wal ace SS Mazor Z Froum SJ | | 0，，05： | 1 |
| 9 | Effect of platelet rich plasma on bone growth and osseointegration in human maxillary sinus grafts:Three bilateral case reports显示文摘 | FROUM S J WALLACE S S TARNOW D P | 2002 | Int J Periodont Restor Dent2002，22，1： | 1 |
| 10 | Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain显示文摘 | Mohammadi M Froum S Hamby J M | 1998 | Embo J1998，17，20： | 1 |
| 11 | A prospective 2-year clinical evaluation of overdentures at tached to nonsplinted implants utilizing ERA attachments 显示文摘 | Landa LS Cho SC Froum SJ | 2001 | Pract Proced Aesthet Dent2001，13，15： | 1 |
| 12 | Trophic effects of platelets on cultured endothelial cells are mediated by platelet associated fibroblast growth factor2 (FGF-2) and vascular endothelial growth factor (VEGF) 显示文摘 | Pintucci G Froum S Pinnell J | 2002 | Thromb Haemost2002，88，5： | 1 |
| 13 | A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12- month re-entry study显示文摘 | Froum SJ Weinberg MA Rosenberg E | 2001 | J Periodontol2001，72，1： | 1 |
| 14 | Schneiderian membrane perfo- ration rate during sinus elevation using piezosurgery: clinical results of 100 consecutive cases显示文摘 | Wallace SS Masor Z Froum SJ | 2007 | Int J Periodontics Restorative Dent2007，27，5： | 1 |
| 15 | Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2(FGF-2) and vascular endothelial growth factor(VEGF)显示文摘 | Pintucci G Froum S Pinnell J | 2002 | Thromb Haemost2002，88，7： | 1 |
| 16 | Maxillary sinus elevation by lateral window approach: evolution of technology and techunique 显示文摘 | Wallace SS Tamow DP Froum S J | 2012 | J Evid Based Dent Pract2012，12，3： | 1 |
| 17 | A retr os pective study of 1925 consecutively placed immediate implants from 1988 to 2004 显示文摘 | Wagenberg B Froum SJ | 2006 | Int J OralMaxillofac Implants2006，21，1： | 1 |
| 18 | A comparative stndy utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12-month re-entry study 显示文摘 | Froum SJ Weinberg MA Rosenberg E | 2001 | J Periodontol2001，72，1： | 1 |
| 19 | Histologic evaluation of bone-implant contact of immediately loaded transitional im- plants after 6 to 27 months 显示文摘 | Froum SJ Simon H Cho SC | 2005 | Int J Oral Maxillofac Im- plants2005，20，1： | 1 |
| 20 | The use of CO2 laser in the treatment of peri implantitis 显示文摘 | Romanos G Ko HH Froum S | 2009 | Photomed Laser Surg2009，27，3： | 1 |
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