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| 1 | Pathogenesis of hepatitis B virus infection显示文摘Infection with hepatitis B virus (HBV) leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. Infection with HBV is one of the most common viral diseases affecting man. Both viral factors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of HBV infection. In this review, we will discuss the impact of virus-host interactions for the pathogenesis of HBV infection and liver disease. These interactions include the relevance of naturally occurring viral variants for clinical disease, the role of virus-induced apoptosis for HBV-induced liver cell injury and the impact of antiviral immune responses for outcome of infection. | Thomas F Baumert Robert Thimme Fritz von Weizscker | 2007 | World Journal of Gastroenterology2007，13，1： | 49 |
| 2 | Liver fat content determined by magnetic resonance imaging and spectroscopy显示文摘Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations. | Fabian Springer Jürgen Machann Claus D Claussen Fritz Schick Nina F Schwenzer | 2010 | World Journal of Gastroenterology2010，16，13： | 19 |
| 3 | Phenetic Diversity of Alkaliphilic Bacillus Strains:Proposal for Nine New Species显示文摘 | Nielsen P Fritze D Priest F G | 1995 | Microbiology1995，141，： | 1 |
| 4 | Depression in mild dementia: association with diagnosis, APOE genotype and clinical features 显示文摘 | Fritze F Ehrt U Sonnesyn H | 2011 | Int J Geriatr Psychiatry2011，26，10： | 1 |
| 5 | Inheritance and Mechanisms of Resistance to Anilinopyrimidine Fungicides in Botrytis Cinerea显示文摘 | CHAPELAND F FRITZ R LANEN C | 1999 | Pestic Biochem Physiol1999，64，： | 1 |
| 6 | Arbuscular mycorrhuza redyces susceptibility of tomato to Alternaria salani显示文摘 | FRITZ M JAKOBSEN I LYNGKJAER M F | 2006 | Mycirrhiza2006，16，6： | 1 |
| 7 | A web-based multi-perspective decision support system for information security planning显示文摘 | E1-Gayar O F Fritz B D | 2010 | Decision Support Systems2010，50，1： | 1 |
| 8 | Microarray-based copy number and expression profiling in dedifferentiated and pleomorhic liposarcoma显示文摘 | Fritz B Schubert F Wrobel G | 2002 | Cancer Res2002，62，11： | 1 |
| 9 | 显示文摘 | Macro F Fritz V | 1999 | Angew Chem Int Ed Engl1999，38，： | 1 |
| 10 | RhoGTPases in human breast turnouts: expression and mutation analyses and correlation with clinical parameters 显示文摘 | Fritz G Brachetti C Bahlmann F | 2002 | Br J Cancer2002，87，6： | 1 |
| 11 | The prolonged intake of L- arginine-L-aspartate reduces blood lactate accumulation and oxygen consumption during submaximal exercise显示文摘 | MARTIN B FRITZ B MARTIN F | 2005 | Journal of Sports Science and Medicine2005，，4： | 1 |
| 12 | Variation in the birth sex ratio and neonatal mortality in a natural herd of horses显示文摘 | Monard A M Duncan P Fritz H F | 1997 | Behav Ecol Sociobiol1997，41，： | 1 |
| 13 | Common bileduct obstruction due to malignancy:treatment with plastic versus metal stents显示文摘 | Johannes L Llaus AH Fritz F | 1996 | Radiology1996，201，1： | 1 |
| 14 | Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collageninduced arthritis显示文摘 | Djouad F Fritz V Apparailly F | 2005 | Arthritis Rheum2005，52，5： | 1 |
| 15 | Neue lyratolester aus chrysanthemum coronarium 显示文摘 | Bohlmann F Fritz U | 1979 | Phytochemistry1979，18，11： | 1 |
| 16 | Metabolism of Cymoxanil and Analogs in Strains of the Fungus Botrytis Cinerea Using High-performance Liquid Chromatography and Ion-pair High-performance Thin-layer Chromatography 显示文摘 | TELLIER F FRITZ R LEROUX P | 2002 | Journal of Chromatography B2002，769，1： | 1 |
| 17 | The genome response to artificial selection: a case study in dairy cattle显示文摘 | Flori L Fritz S Jaffr6zic F | 2009 | PLoS One2009，4，8： | 1 |
| 18 | Why Do Firms Hold So Much Cash?A Tax-based Explanation显示文摘 | Fritz F Hartzell J Titman S | 2007 | Journal of Financial Economics2007，86，： | 1 |
| 19 | Impact of di(2-ethylhexyl)phthalate on migration rate of human promyelocytic leukemia cel s(HL-60)显示文摘 | Manz P Cadeddu RP Wilk M Fritz B Haas R Wenzel F | 2014 | Clin Hemorheol Microcirc2014，58，1： | 1 |
| 20 | Small (Sendai negative) branch-duct IPMNs: not harmless 显示文摘 | Fritz S Klauss M Bergmann F | 2012 | Ann Surg2012，256，2： | 1 |
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