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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Isolated cortical venous thrombosis presenting as subarachnoid hemorrhage: a report of three cases显示文摘 | Chang R Friedman DP | 2004 | AJNR Am J Neuroradiol2004，25，： | 1 |
| 3 | Multiple sclerosis in the spinal cord:MR appearance and correlation with clinical parameters显示文摘 | Tartaglino LM Friedman DP Flanders AE | 1995 | Radiology1995，195，3： | 1 |
| 4 | Comparison of hippocampal,amygdala, and perirhinal projections to the nucleus accumbens:combined anterograde and retrograde tracing study in the Macaque brain显示文摘 | Friedman DP Aggleton JP Saunders RC | 2002 | J Comp Neurol2002，450，4： | 1 |
| 5 | Vascular neoplasms and malformations,ischemia,and hemorrhage affecting the spinal cord:MR imaging findings显示文摘 | Friedman DP Flanders AE Tartaglino IM | 1994 | AJR1994，162，3： | 1 |
| 6 | Quantification of carotid stenosis on CT angiography - does gender matter显示文摘 | Friedman DP | 2006 | AJNR Am J Nettroradiol2006，27，8： | 1 |
| 7 | Isolated cortical venous thrombosis presenting as subarachnoid hemorrhage:a report of three cases显示文摘 | Chang R Friedman DP | 2004 | AJNR Am J Neuroradiol2004，，： | 1 |
| 8 | Helicobacter pylori infection and the risk of gastric carcinoma显示文摘 | parsonnet J Friedman GD Vandersteen DP | 1991 | N Engl J Med1991，325，16： | 1 |
| 9 | Thalamic connectivity of the second somatosensory area and neighboring somatosensory fields of the lateral sulcus of the macaque显示文摘 | Friedman DP Murray EA | 1986 | J Comp Neurol1986，252，3： | 1 |
| 10 | Helicobacter pylori infection and the risk of gastric carcinoma显示文摘 | Parsonnet J Friedman GD Vandersteen DP | 1991 | N Engl J Med1991，325，16： | 1 |
| 11 | Helicobacter pylori infection and the risk of gastric carcinoma显示文摘 | Friedman GD Vandersteen DP | 1991 | N Eng J Med1991，325，： | 1 |
| 12 | Multiple sclerosis in the spinal cord:MR appearance and correlation with clinical parameters显示文摘 | Tartaglino LM Friedman DP Flanders AE | 1995 | Radiology1995，195，3： | 1 |
| 13 | Intradural Schwannomas of the Spine: MR Findings with Emphasis on Contrast-Enhancement Characteristics显示文摘 | Friedman DP Tartaglino LM Flanders AE | 1992 | AJR1992，158，6： | 1 |
| 14 | Magnetic resonance imaging in acute cervical spinal injury显示文摘 | Tartaglino LM Friedman DP | 1992 | Semin Roentgenol1992，27，4： | 1 |
| 15 | Superior sagittal sinus thrombosis in the presence of idiopathic bilateral internal jugular vein stenosis显示文摘 | Saponaro SA Flanders AE Friedman DP | | 0，，01： | 1 |
| 16 | Most mammalian mRNAs are conserved targets of microRNAs 显示文摘 | Friedman RC Farh KK Burge CB Bartel DP | 2009 | Genome Res2009，19，1： | 1 |
| 17 | Gamma knife pallidotomy in advanced Parkinson's disease显示文摘 | Friedman DP Epstein M Sanes JN | 1996 | Ann Neurol1996，39，： | 1 |
| 18 | Stereotactic radiosurgical pallidotomy and thalamotomy with the gamma knife:MR imaging findings with clinical correlation-preliminary experience显示文摘 | Friedman DP Goldman W Flanders AE | 1999 | Radiology1999，212，： | 1 |
| 19 | Helicobacter pylori infection and the risk of gastric carcinoma 显示文摘 | Parsonnet J Friedman CD Vandersteen DP | 1991 | N Eng J Med1991，325，16： | 1 |
| 20 | Endanced MR imaging of hypertropic pachymeningitis显示文摘 | Friedman DP Flanders AE | 1997 | Am J Roentgenol1997，169，： | 1 |
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