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| 1 | Key players in pancreatic cancer-stroma interaction: cancer-associated fibroblasts, endothelial and inflammatory cells显示文摘Pancreatic cancer(PC) is the most aggressive type of common cancers, and in 2014, nearly 40000 patients died from the disease in the United States. Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is characterized by an intense stromal desmoplastic reaction surrounding the cancer cells. Cancer-associated fibroblasts(CAFs) are the main effector cells in the desmoplastic reaction, and pancreatic stellate cells are the most important source of CAFs. However, other important components of the PC stroma are inflammatory cells and endothelial cells. The aim of this review is to describe the complex interplay between PC cells and the cellular and noncellular components of the tumour stroma. Published data have indicated that the desmoplastic stroma protects PC cells against chemotherapy and radiation therapy and that it might promote the proliferation and migration of PC cells. However, in animal studies, experimental depletion of the desmoplastic stroma and CAFs has led to more aggressive cancers. Hence, the precise role of the tumour stroma in PC remains to be elucidated. However, it is likely that a contextdependent therapeutic modification, rather than pure depletion, of the PC stroma holds potential for the development of new treatment strategies for PC patients. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2016 | World Journal of Gastroenterology2016，22，9： | 20 |
| 2 | A trait-based approach to assess climate change sensitivity of freshwater invertebrates across Swedish ecoregions显示文摘 | Leonard SANDIN Astrid SCHMIDT-KLOIBER Jens-Christian SVENNING Erik JEPPESEN Nikolai FRIBERG | 2014 | Current Zoology2014，60，2： | 3 |
| 3 | The effect of vitreous and retinal surgery on corneal endothelial cell density 显示文摘 | Friberg TR Doran DL Lazenby FL | 1984 | Ophthalmology1984，91，： | 2 |
| 4 | Typing of pancreatic cancer-associated fibroblasts identifies different subpopulations显示文摘AIM To determine whether it is possible to identify different immune phenotypic subpopulations of cancer-associated fibroblasts (CAFs) in pancreatic cancer (PC). METHODS We defined four different stromal compartments in surgical specimens with PC: The juxtatumoural, peripheral, lobular and septal stroma. Tissue microarrays were produced containing all pre-defined PC compartments, and the expression of 37 fibroblast (FB) and 8 extracellular matrix (ECM) markers was evaluated by immunohistochemistry, immunofluorescence (IF), double-IF, and/or in situ hybridization. The compartment-specific mean labelling score was determined for each marker using a four-tiered scoring system. DOG1 gene expression was examined byquantitative reverse transcription PCR (qPCR). RESULTS CD10, CD271, cytoglobin, DOG1, miR-21, nestin, and tenascin C exhibited significant differences in expression profiles between the juxtatumoural and peripheral compartments. The expression of CD10, cytoglobin, DOG1, nestin, and miR-21 was moderate/strong in juxtatumoural CAFs (j-CAFs) and barely perceptible/weak in peripheral CAFs (p-CAFs). The upregulation of DOG1 gene expression in PC compared to normal pancreas was verified by qPCR. Tenascin C expression was strong in the juxtatumoural ECM and barely perceptible/weak in the peripheral ECM. CD271 expression was barely perceptible in j-CAFs but moderate in the other compartments. Galectin-1 was stronger expressed in j-CAFs vs septal fibroblasts, PDGFRβ, tissue transglutaminase 2, and hyaluronic acid were stronger expressed in lobular fibroblasts vs p-CAFs, and plectin-1 was stronger expressed in j-CAFs vs l-FBs. The expression of the remaining 33 markers did not differ significantly when related to the quantity of CAFs/FBs or the amount of ECM in the respective compartments.CONCLUSION Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. Future studies should determine whether CAF subpopulations have different functional properties. | Michael Friberg Bruun Nielsen Michael Bau Mortensen Sonke Detlefsen | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 5 | Natural Killer cells and natural killer cells activity in chronic fatigue syndrome显示文摘 | Whitedise TL Friberg D Pittsburgh | 1998 | Ame J Med1998，105，3： | 2 |
| 6 | Transcervical balloon tuboplasty显示文摘 | Confino E Friberg J Gleicher N | 1986 | Fertil Steril1986，46，5： | 1 |
| 7 | Frequency of epithelial debridement during diabetic vitrectomy 显示文摘 | Friberg TR Ohji M Scherer J J Tano Y | 2003 | Am J Ophthalmol2003，135，4： | 1 |
| 8 | Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnea and habitual snores 显示文摘 | Friberg D Gazolius B | 1997 | Regal Pept1997，71，1： | 1 |
| 9 | Interpretation and experimental demonstration of twisted Gaussian Schell-model beams显示文摘 | Friberg A T Tervonen E Turunen J | 1994 | J Opt Soc Am A1994，46，： | 1 |
| 10 | In Which Currency Should Exporters Set Their Price显示文摘 | Friberg Richard | 1998 | Joumal of ntemational Economics1998，，45： | 1 |
| 11 | Diabetes and risk of endometrial cancer:a population based prospective cohort study显示文摘 | Friberg E Mantzoros CS Wolk A | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，2： | 1 |
| 12 | 查看详情显示文摘 | Turunen J Friberg A T | | 0，，： | 1 |
| 13 | Phase Ⅱ trial of bevacizumab plus gemcitabine in pantients with advanced pancreatic cancer显示文摘 | Kindler Hedy L Friberg Gregory Singh Deepti A | 2005 | J Clin Oncol2005，23，： | 1 |
| 14 | Diabetes mellitus and risk of endometrial cancer:a meta-analysis显示文摘 | Friberg E Orsini N Mantzoros CS | 2007 | Diabetologia2007，50，7： | 1 |
| 15 | Inhibition of the human tissue plasminogen activator in plasma from different species显示文摘 | Hggroth L Mattsson C Friberg J | 1984 | Thromb Res1984，33，6： | 1 |
| 16 | In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocomponent or the state of activation显示文摘 | Friberg D Bryant J Shannon W | 1999 | Clin Diagn Immunol1999，1，3： | 1 |
| 17 | Abnormal afferent nerve endings in the soft palatal mucosa of sleep apneics and habital snorers显示文摘 | Friberg D Gazelius B Hokfelt T | 1997 | Regulatory Peptides1997，71，： | 1 |
| 18 | Cardiac sympathetic nerve function in congestive heart failure显示文摘 | Eisenhofer G Friberg P Rundqvist B | 1996 | Circulation1996，93，9： | 1 |
| 19 | Stroke in paroxysmal atrial fibrillation: report from the Stockholm Cohort of Atrial Fibrillation显示文摘 | Friberg L Hammar N Rosenqvist M | 2010 | Eur Heart J2010，31，8： | 1 |
| 20 | Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure显示文摘 | Petersson M Friberg P Eisenhofer G | 2005 | Eur Heart J2005，26，： | 1 |
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