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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 3 | Evaluation of ZnO,TiO2 and supported ZnO on the photoassisted remediation of black liquor,cellulose and textile mill effluents显示文摘 | Peralta-Zamora P Pelegrini R Freire M | 1998 | Chemosphere1998，36，9： | 1 |
| 4 | Split-step Fourier migration显示文摘 | Fokkema J T Freire R M | | Geophysics0，55，： | 1 |
| 5 | Single nucleotide polymorphism for population studies in the scallops Aequipecten opercularis and Mimachlamys varia显示文摘 | Arias A Freire R Boudry P | 2008 | Conserv Genet2008，56，： | 1 |
| 6 | The numerical computation of near-wall turbulent flow over a steep hill 显示文摘 | Juliana B R Loureiro Alexandre T P Alho Atila P Silva Freire | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 7 | What is the 'Dialogical Method' of Teaching ? 显示文摘 | Shor I Freire P | 1987 | Journal of Education1987，169，： | 1 |
| 8 | Study of the diffusion coefficients of diphenylbutadiene and triclosan into and within meat显示文摘 | Sanches Silva A Freire J M C Losada P P | 2010 | European Food Research and Technology2010，230，6： | 1 |
| 9 | Structural assessment of minor axis steel joints using photoelasticity and finite elements 显示文摘 | Lima L R O Freire J L F Vellasco P C G S | 2009 | Journal of Constructional Steel Research2009，65，2： | 1 |
| 10 | Part 3 : Burst tests of pipeline with extensive longitudinal metal loss 显示文摘 | Freire J L F Vieira R D Castro J T P | 2006 | Experimental Techniques2006，30，6： | 1 |
| 11 | Bloodstream infection caused by extensively drag-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia显示文摘 | Freire M P de Oliveira Garcia D Garcia C P | 2015 | Clin Microbiol Infect2015，，： | 1 |
| 12 | Urodynamie pressure flow studies can predict the clinical outcome after transurethal prostatic section显示文摘 | Rodrigues P Lucon AM Freire GC | 2001 | J Urol2001，165，2： | 1 |
| 13 | Characteristics associated with analgesia ordering in the intensive care unit and relationships with outcome显示文摘 | Freire AX Afessa B Cawley P | 2002 | Crit Care M ed2002，30，： | 1 |
| 14 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 15 | Comparative effects of dietary fat and fibre in Alentejano and Large White piglets: digestibility, digestive enzymes and metabolic data 显示文摘 | Freire J P B Peiniau J Cunha L F | 1998 | Liv Prod Sci1998，53，： | 1 |
| 16 | Estabilidade Fisico-qutmica,Mierobiol6giea E Sensorial De Came Ovina Embalada a Vaeuo Estocada Sob Refrigeraqao 显示文摘 | FERNANDES R P P FREIRE M T A GUERRA C C G | 2012 | Ciencia Rural Santa Maria2012，42，4： | 1 |
| 17 | Split -step Fourier migration显示文摘 | Stoffa P L Fokkema J T Freire R M Kessinger W P | 1990 | Geophysics1990，55，： | 1 |
| 18 | Split-step Fourier Migration显示文摘 | Stoffa P L Fokkema J T De Luna Freire R M | 1990 | Geophysics1990，55，4： | 1 |
| 19 | Urodynamics pressure flow studies can predict the clinical outcome after transurethral prostatic resection显示文摘 | Ridrignes P Lueon AM Freire GC | 2001 | J Urol2001，165，2： | 1 |
| 20 | The effect of genotype and dietary fibre level on thecaecal bacterial enzymeactivity of young piglets:Digestive consequences显示文摘 | FREIRE J P B DIAS R I M CUNHA L F | 2003 | Animal feed science and technology2003，106，： | 1 |
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