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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 3 | 水基微泡钻井液和油基微泡钻井液的应用显示文摘微泡是就地产生的特别稳定的微气泡以抑制钻井液漏入高渗地层。水基微泡用于水基钻井液中 ,而油基微泡用于非水基钻井液中。在两种情形下 ,微气泡都由专门的聚合物和表面活性剂稳定的气体或液体的核构成 ,在渗透性地层中这些微泡能聚集形成坚韧的具有弹性的屏障 ,从而阻止钻井液的漏失。在渗透性地层中具有代表性的是水湿砂岩 ,容易发生钻井液渗漏和压差卡钻。另外一些地层由砂岩和页岩构成 ,对这些地层使用常规钻井液或欠平衡钻井设备都非常昂贵。作者描述了在钻井液中如何利用水基和油基微泡减轻井下的钻井液漏失。 | Frederick B Growcock 王瑛 武学芹 张敬辉 | 2004 | 国外油田工程2004，20，1： | 4 |
| 4 | Detection of PR vi- ral DNA in tonsillar cells of latently infected pigs 显示文摘 | Talmage T B Kwang O S Frederick J F | 1995 | Am J Vet Res1995，56，5： | 1 |
| 5 | Seed yield and agronomic traits of old and modem soybean cultivars under irrigation and soil water-deficit显示文摘 | Frederick J R Woolley J T Hesketh J D Peters D B | 1991 | Field Crops Research1991，27，： | 1 |
| 6 | A randomized trial of two types of nurse-assisted home care for patients with COPD显示文摘 | Coultas D Frederick J Barnett B | 2005 | Chest2005，128，4： | 1 |
| 7 | Printed circuit board technology inspired stretchable circuits 显示文摘 | JAN V MARIO G FREDERICK B etal | 2012 | MRS Bulletin2012，37，3： | 1 |
| 8 | Pollen-mediated gene flow in California cotton depends on pollinator activity显示文摘 | ALLEN E V D Frederick J S Kent J B | 2005 | Crop Science2005，45，4： | 1 |
| 9 | Combustion effects of C6osoot in ammonium nitrate propellants显示文摘 | Greiner B E Frederick R A Maser M D | | 0，，4： | 1 |
| 10 | Pediatric primary diffuse large cell lymphoma of bone with t (3;22)(q27; q11)显示文摘 | Federico A Frederick B Susana R | 1998 | J Pedia Hemotol1998，20，： | 1 |
| 11 | Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease显示文摘 | Bénédicte Stengel Michelle E. Tarver–Carr Neil R. Powe Mark S. Eberhardt Frederick L. Brancati | 2003 | Epidemiology2003，，4： | 1 |
| 12 | Guaiacol hydrodeoxygenation on MoS2 catalysts:Influence of activated carbon supports显示文摘 | Ruiz P E Frederick B G De Sisto W J | | 0，，： | 1 |
| 13 | Two-di-mensional,J-resolved spectroscopic imaging of GABA at 4tes-la in the human brain显示文摘 | JENSEN J E FREDERICK B D WANG L | 2005 | Magnetic Resonance in Medicine2005，54，4： | 1 |
| 14 | Full-Scale Test of Prestressed Double-Tee Beam 显示文摘 | Nabil F Grace George Abdel-Sayed Frederick C Navarre Richard B Nacey Wayne Bonus Loris Collavino | 2003 | Concrete International2003，，4： | 1 |
| 15 | A contribution towards understanding the biospherical significance of Antarctic ozone depletion显示文摘 | LUBIN D MITCHELL B G FREDERICK J E | 1992 | Journal of Geophysics Research1992，97，： | 1 |
| 16 | ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy显示文摘 | Frederick B Gustafson D Bianco C | 2006 | Int J Radiat Oncol Biol Phys2006，，： | 1 |
| 17 | The role of S mad3 in mediating mouse hepatic stellate cell activation显示文摘 | Schnabl B Kweon YO Frederick JP | 2001 | Hepatology2001，34，1： | 1 |
| 18 | The deleterious effects of mtraop-erative hypotension on outcome in patients with severe head injuries显示文摘 | John A Pietropaoli MD Frederick B | 1992 | J Trauma1992，33，： | 1 |
| 19 | The future of electrical and computer engineering education显示文摘 | Frederick C B Philip S D Susan L S | 2003 | IEEE Transactions on Education2003，46，4： | 1 |
| 20 | Predation by juvenile piscivorous bluefish (Pomatomus saltatrix):the influence of prey to predator size ratio and prey type on predator capture success and prey profitability显示文摘 | FREDERICK S S JEFFREY A B FRANCIS JUANES | 1998 | Canadian Journal of Fisheries and Aquatic Sciences1998，55，： | 1 |
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