| 5 | Diagnosis and management of small bowel neuroendocrine tumors:A state-of-the-art显示文摘This review provides an update on the epidemiology,pathophysiology,symptoms,diagnosis and treatment of neuroendocrine neoplasms(NENs)of the small bowel(SB).These NENs are defined as a group of neoplasms deriving from neuroendocrine cells.NENs are currently the most common primary tumors of the SB,mainly involving the ileum,making the SB the most frequently affected part of the gastrointestinal tract.SB NENs by definition are located between the ligament of Treitz and the ileocecal valve.They are characterized by small size and induce an extensive fibrotic reaction in the small intestine including the mesentery,resulting in narrowing or twisting of the intestine.Clinical manifestations of bowel functionality are related to the precise location of the primary tumor.The majority of them are non-functional NENs and generally asymptomatic;in an advanced stage,NENs present symptoms of mass effect by non-specific abdominal pain or carcinoid syndrome which appears in patients with liver metastasis(around 10%).The main manifestations of the carcinoid syndrome are facial flushing(94%),diarrhea(78%),abdominal cramps(50%),heart valve disease(50%),telangiectasia(25%),wheezing(15%)and edema(19%).Diagnosis is made by imaging or biochemical tests,and the order of request will depend on the initial diagnostic hypothesis,while confirmation will always be histological.All patients with a localized SB NEN with or without near metastasis in the mesentery are recommended for curative resection.Locoregional and distant spread may be susceptible to several therapeutic strategies,such as chemotherapy,somatostatin analogs and palliative resection. | Jhean Gabriel Gonzáles-Yovera Pela J Roseboom Marcio Concepción-Zavaleta Isamar Gutiérrez-Córdova Esteban Plasencia-Dueñas María Quispe-Flores Anthony Ramos-Yataco Carlos Alcalde-Loyola Frederick Massucco-Revoredo JoséPaz-Ibarra Luis Concepción-Urteaga | 2022 | World Journal of Methodology2022，12，5： | 0 |
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