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| 1 | Current medical treatment of estrogen receptor-positive breast cancer显示文摘Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness. | Franco Lumachi Davide A Santeufemia Stefano MM Basso | 2015 | World Journal of Biological Chemistry2015，6，3： | 16 |
| 2 | Biofeedback and the electromyographic activity of pelvic floor muscles in pregnant women 显示文摘 | Batista RL Franco MM Naldoni LM | 2011 | Rev Bras Fisioter2011，15，5： | 1 |
| 3 | 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis显示文摘 | Morales JC Franco S Murphy MM | 2006 | Proc Natl Aead Sci U S A2006，103，9： | 1 |
| 4 | Modulation of microglial activation enhances neuroprotection and func-tional recovery derived from bone marrow mononuclear cell transplantation after cortical ischemia 显示文摘 | Franco EC Cardoso MM Gouveia A | 2012 | Neurosci Res2012，73，2： | 1 |
| 5 | Human osteoblastic cell response to a Ca- and P-enriched titanium surface obtained by anodization显示文摘 | Franco RL Chiesa R Beloti MM | 2009 | Journal of Biomedical Materials Research Part A2009，88，4： | 1 |
| 6 | Anti-enteropathogenic escherichia coli immunobulin Y isolated from eggs laid by immunised Leghorn chickens显示文摘 | Amaral JA Tino De Franco M Carneiro-Sampaio MM | 2002 | Res Vet Sci2002，72，3： | 1 |
| 7 | Isolation and identification of acti-nobacteria from surface-sterilized wheat roots显示文摘 | Coombs J T Franco C MM | 2003 | Appl EnvironMicrobiol2003，69，9： | 1 |
| 8 | Human papillomaviras infection in postmenopausal women with and without hormone ther- apy显示文摘 | Ferenczy A Gelfand MM Franco E | 1997 | Obstet Gynecol1997，90，1： | 1 |
| 9 | A nonantibiotic chemically modified tetracycline ( CMT - 3 ) inhibits intimal thicking显示文摘 | Islam MM Franco CD Courtman DW | 2003 | Am J Pathol2003，163，4： | 1 |
| 10 | Biofeedback and the electromyographic activity of pelvic floor muscles in pregnant women 显示文摘 | Batista RL Franco MM Naldoni LM | 2011 | Rev Bras Fisioter2011，15，5： | 1 |
| 11 | Anti- enteropathogenic Escherichia coil immunobulin Y isolated from eggs laid by immunized Leghorn chickens 显示文摘 | Amaral JA Tino De Franco M Cameiro-Sampaio MM | 2002 | Res Vet Sci2002，72，3： | 1 |
| 12 | Human osteoblastic cell response to a Ca-and P-enriched titanium surface obtained by an- odization显示文摘 | Franco Rde L Chiesa R Beloti MM | 2009 | J Biomed Mater Res A2009，88，4： | 1 |
| 13 | High resolution co- mput-erized tomograghy tuberculosis with negative sputum bacil- loscopy显示文摘 | Conzalez CE Franco SJ Domingo MM | 2003 | Rev Clin Esp2003，203，： | 1 |
| 14 | Connecting TNF - a signaling path- ways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amy- loid β protein 显示文摘 | Medeiros R Prediger RD Passos GF Pandolfo P Duarte FS Franco JL Dafre AL Di Giunta G Figueiredo CP Takahashi RN Campos MM Calixto JB | 2007 | The Journal of Neuroscience2007，27，20： | 1 |
| 15 | Biofeedback and the electromyographic activity of pelvic floor muscles in pregnant women显示文摘 | Batista RL Franco MM Naldoni LM | 2011 | Rev Bras Fisioter2011，15，5： | 1 |
| 16 | Occult breast carcinoma presenting with axillary lymph node metastasis显示文摘 | Medina - Franco H Urist MM | 2002 | Rev Invest Clin2002，54，3： | 1 |
| 17 | Biofeedback and he electmmyographie activity of pelvic' floor muscles in pregnant women显示文摘 | Batista BL Franco MM Naldoni LM | 2011 | Rev Bras Fisioter2011，15，5： | 1 |
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