|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Maize and radish sequester excess cadmium and zinc in different ways显示文摘 | Francisco S J Rauser W E | 2003 | Plant Science2003，165，： | 1 |
| 3 | Lithium-ion trapping from local structural distortions in sodium super ionic conductor (NASICON) electrolytes显示文摘 | Francisco B E Stoldt C R M'Peko J C | 2014 | Chemistry of Materials2014，26，16： | 1 |
| 4 | A rise of ploidy level induces the expression of apomixis in Paspalum notatum 显示文摘 | Quarin C L Francisco E Eric J | 2001 | Sex Plant Reprod2001，13，5： | 1 |
| 5 | First-principles study of the rocksalt-cesium chloride relative phase stability in alkali halides显示文摘 | F1arez M Recio J M Francisco E | 2002 | Phys Rev B2002，66，14： | 1 |
| 6 | First-principles Study of the Rocksalt-cesium Chloride Relative Phase Stability in Alkalihalides显示文摘 | FLOREZ M RECIO J M FRANCISCO E | | 0，，： | 1 |
| 7 | Discrete models for vertical vibrations of surface and embedded foundation 显示文摘 | Francisco C P Barros D Luco J E | 1990 | Earthquake Engineering and Structure Dynamics1990，19，2： | 1 |
| 8 | The conformation of histone h5 显示文摘 | AVILES Francisco J CHAPMAN George E KNEALE Geoff G | 1978 | Europe- an Journal of Biochemistry1978，88，2： | 1 |
| 9 | High Cartier Density and Capacitance in TiO2 Nanotube Arrays Induced by Electrochemical Doping显示文摘 | FRANCISCO F S BAREA E M BISQUERT J | 2008 | Journal of the American Society2008，130，11： | 1 |
| 10 | First-principles study of the rocksalt:Cesium chloride relative phase stability in alkali halides显示文摘 | Florez M Recio J M Francisco E | 2002 | Phys Rev2002，66，14： | 1 |
| 11 | Varietal differences among the polyphenol profiles of seven table grape cuhivars studied by LC-DAD-MS-MS 显示文摘 | Cantos E Espln J C Francisco A | 2002 | J Agric Food Chem2002，50，20： | 1 |
| 12 | Photoelectrocatalytic oxidation of remazol turquoise blue and toxicological assessment of its oxidation products 显示文摘 | Marli E Osugi Gisela A Umbuzeiro Francisco J V De Castro | 2006 | Joumal of Hazardous Materials2006，137，2： | 1 |
| 13 | The use of tungsten-rhodium permanent chemical modifier for cadmium determination in decomposed samples of biological materials and sediments by electrothermal atomic absorption spectrometry显示文摘 | Lima E C Fernando Barbosa Jr Francisco J Krug | 2000 | Anal Claim Acta2000，，409： | 1 |
| 14 | Analyzing the cost effectiveness of Santiago, Chile's policy of using urban forests to improve air quality显示文摘 | Francisco J John E David J etc | 2008 | Journal of Environmental Management2008，86，： | 1 |
| 15 | Crystal struc- ture of a bacterial endospore coat component 显示文摘 | Francisco J E Lisia OM Adriano 0 H | 2003 | The Jour- nal of Biological Chemistry2003，278，19： | 1 |
| 16 | Quantum-Mechanical study of thermodynamic and bonding properties of MgF2显示文摘 | FRANCISCO E RECIO J M BLANCO M A | 1998 | The Journal of Physical Chemistry A1998，102，9： | 1 |
| 17 | Maize and radish sequester excess cadmium and zinc in different ways显示文摘 | Francisco S J Rauser W E | 2003 | Plant Sci2003，165，： | 1 |
| 18 | Translocatable leaf signal autoregulares soybean nodulation显示文摘 | Francisco P B J Harper J E | 1995 | Plant Science1995，107，： | 1 |
| 19 | Crystal structure of a bacterial endospore coat component显示文摘 | Ligia O M Adriano O H | 2003 | J Biolo Chem2003，278，19： | 1 |
| 20 | Androgen receptor expression and outcomes in early breast cancer:A systematic review and Meta-analysis显示文摘 | Francisco E Vera-Badillo Arnoud J | 2014 | J Natl Cancer Inst2014，106，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员