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| 1 | Estrogens and the pathophysiology of the biliary tree显示文摘有关不同纸巾上的雌激素效果的科学框架在最后十年期间极其膨胀了,当时雌激素受体(嗯) 子类型被识别。雌激素是不仅必要的因为雌性生殖系统,而且他们也包括心血管系统,骨头,大脑和肝在另外的纸巾控制基本功能。最近,在他们调制 cholangiocytes 的增生的和分泌活动的地方,雌激素被显示了指向胆汁的树,上皮细胞衬里胆汁管。由在两雌激素受体(ER-alpha ) 并且(上扮演嗯贝它) 子类型,并且由激活 genomic 或 non-genomic 小径,雌激素在生长因素和 cytokines 的复杂的环起一个关键作用,它调制 cholangiocytes 的增生的反应损坏。明确地,雌激素激活细胞内部的发信号的串联[英皇家空军之阶级最低之兵( 1/2 )(细胞外的调整家族 ases ( 1/2 ),PI3- kinase/AKT (phosphatidylinositol-3' kinase/AKT )]典型地代表象象生长因素( IGF1 )一样的胰岛素那样的生长因素,神经生长因素( NGF )和脉管的内皮生长因素( VEGF ),因此加强他们的行动。另外,雌激素在增殖的 cholangiocytes 刺激不同生长因素的分泌物。这评论明确地处理与雌激素处于正常、病理学的条件由调制 cholangiocyte 功能的角色和机制有关的最近的进展。 | Domenico Alvaro Maria Grazia Mancino Paolo Onori Antonio Franchitto Gianfranco Alpini Heather Francis Shannon Glaset Eugenio Gaudio | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 2 | Cholangiocytes and blood supply显示文摘胆汁的树的微脉管的供应,仙子胆管丛(PBP ) ,源自肝的动脉树枝和流动进肝窦状隙。PBP 的详细三维的研究被使用扫描电子执行了显微镜学脉管的腐蚀演员组(SEMvcc ) 技术。认为 PBP 在支持胆汁的上皮的能分泌、吸收性的功能起一个基本作用,他们在常态和病理的组织被探索。正常的肝证明 PBP 安排在 extra-附近 -- 并且肝内的胆汁的树。在小门道, PBP 被日益增多地继续了它显示出一个更复杂的脉管的网络的额外的肝的 PBP 的 capillaries 的单个层描绘。在普通的管结扎(BDL ) 以后,胆汁管和 PBP 增长的进步修正被观察。PBP 介绍在许多胆汁管附近安排的一个三维的网络并且作为容器的捆出现,由有典型圆网孔结构的同类的直径的 capillaries 镇静。PBP 网络从显得正常的正弦曲线网络是容易可区分的。在 BDL 期间考虑 PBP 的庞大的延期,脉管的内皮生长因素(VEGF ) 起的可能的作用被评估。VEGF -- A, VEGF-C 和他们的相关受体高度出现了在 BDL 老鼠的增殖的 cholangiocytes 积极的免疫。到象肝的动脉结扎一样的 BDL 老鼠的 anti-VEGF-A 或 anti-VEGF-C 抗体的管理导致了一个减少的胆汁管团。rVEGF 的管理 -- 到 BDL 肝的动脉的 A 绑扎老鼠阻止了 cholangiocyte 增长和 VEGF 的减少 -- 表情作为与 BDL 控制老鼠相比。这些数据处于 cholangiocyte 增长的条件建议胆汁的树的动脉的血供给的角色,例如它发生在长期的胆汁郁积期间。在另一方面, VEGF 作为在 cholangiocytes 和 PBP endothelial 之间的串音的一个工具起的作用建议 VEGF 版本和功能的那操作能为肝的动脉或胆汁的树的损坏描绘的人的病理学的条件代表治疗学的策略。 | Eugenio Gaudio Antonio Franchitto Luigi Pannarale Guido Carpino Gianfranco Alpini Heather Francis Shannon Glaser Domenico Alvaro Paolo Onori | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 3 | Role of sex hormones in the modulation of cholangiocyte function显示文摘Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. | Romina Mancinelli Paolo Onori Sharon DeMorrow Heather Francis Shannon Glaser Antonio Franchitto Guido Carpino Gianfranco Alpini Eugenio Gaudio | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 4 | Hepatic microvascular features in experimental cirrhosis:a structural and morphometrical study in CCl4-treated rats显示文摘 | ONORI P MORINI S FRANCHITTO A | 2000 | J Hepatology2000，33，： | 1 |
| 5 | Tonic chemoreflex activation contributes to increased sympathetic nerve activity in heart failure-related anemia显示文摘 | Franchitto N Despas F Labrunee M | 2010 | Hypertension2010，55，4： | 1 |
| 6 | Ultrastructural dynamics of the human endometrium from 14 to 22 weeks of gestation 显示文摘 | Barberini F Makabe S Franchitto G | 2007 | Arch Histol Cytol2007，70，1： | 1 |
| 7 | Cholangiocytes and blood supply显示文摘 | Gaudio E Franchitto A Pannarale L | 2006 | World J Gastroenterol2006，12，22： | 1 |
| 8 | Polycystic Liver Diseases显示文摘 | Onori P Franchitto A Mancinelli R | 2010 | Dig Liver Dis2010，42，4： | 1 |
| 9 | Levosimedan improves hemodynamics functions without sympathetic activation in severe heart failure patients: direct evidence from sympathetic neural recording显示文摘 | Despas F Trouillet C Franchitto N et aI | 2010 | Acute Card Care2010，12，1： | 1 |
| 10 | New insights into liver stem cells显示文摘 | E. Gaudio G. Carpino V. Cardinale A. Franchitto P. Onori D. Alvaro | 2009 | Digestive and Liver Disease2009，，7： | 1 |
| 11 | Hepatic microcirculation and cholangiocyte physiopathology显示文摘 | Gaudio E Onori P Franchitto A | 2005 | Ital J Anat Embryol2005，10，21： | 1 |
| 12 | Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | G. Carpino S. Morini S. Ginanni Corradini A. Franchitto M. Merli M. Siciliano F. Gentili A. Onetti Muda P. Berloco M. Rossi A.F Attili E. Gaudio | 2005 | Digestive and Liver Disease2005，，5： | 1 |
| 13 | Intracellular pathways mediating estrogen- induced eholangiocyte proliferation in the rat显示文摘 | Alvaro D Onori P Metalli V D Svegliati Baroni G Folli F Franchitto A | 2002 | Hepatology2002，36，： | 1 |
| 14 | Hepatic microvascular fea- tures in experimental cirrhosis: a structural and morphometrical study in CC14-treated rats显示文摘 | Onori P Morini S Franchitto A | 2000 | J Hepatol2000，33，： | 1 |
| 15 | Cholangioeytes and blood supply 显示文摘 | Gaudio E Franchitto A Pannarale L | 2006 | World J Gastroentenal2006，12，22： | 1 |
| 16 | Hepatic microcirculation and cholangiocyte physiopathology显示文摘 | Gaudio E Onori P Franchitto A | 2005 | Ital J Anat Embryol2005，110，21： | 1 |
| 17 | The fascial structures of the rectum and the “so-called mesorectum”: an anatomical or a terminological controversy?显示文摘 | Eugenio Gaudio Alessandro Riva Antonio Franchitto Guido Carpino | 2010 | Surgical and Radiologic Anatomy2010，，2： | 1 |
| 18 | The fascial structures of the rectum and the 'so-called mesorectum' : an anatomical or a terminological controversy? 显示文摘 | Gaudio E Riva A Franchitto A | 2010 | Surg Radiol Anat2010，32，2： | 1 |
| 19 | New insights into liver stem cells显示文摘 | E. Gaudio G. Carpino V. Cardinale A. Franchitto P. Onori D. Alvaro | 2009 | Digestive and Liver Disease2009，，7： | 1 |
| 20 | Activated hepatic stellate cells in liver eir- rhosis : a morphologic and morphometrieal study 显示文摘 | Carpino G Franchitto A Morini S Corradini SG Merli M Gaudio E | 2004 | Anat Embryol2004，109，： | 1 |
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