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| 1 | 心力衰竭患者使用曲美他嗪调节代谢对左室功能和磷酸肌酸/三磷酸腺苷比值的影响显示文摘Aims: The addition of trimetazidine to standard treatment has been shown to improve left ventricular(LV) function in patients with heart failure. The aim of this study is to non-invasively assess, by means of in vivo 31P-magnetic resonance spectroscopy(31P-MRS), the effects of trimetazidine on LV cardiac phosphocreatine and adenosine triphosphate(PCr/ATP) ratio in patients with heart failure. Methods and results: Twelve heart failure patients were randomized in a double-blind, cross-over study to placebo or trimetazidine(20 mg t.i.d.) for two periods of 90 days. At the end of each period, all patients underwent exercise testing, 2D echocardiography, and MRS. New York Heart Association(NYHA) class, ejection fraction(EF), maximal rate-pressure product, and metabolic equivalent system(METS) were evaluated. Relative concentrations of PCr and ATP were determined by cardiac 31P-MRS. On trimetazidine, NYHA class decreased from 3.04±0.26 to 2.45±0.52(P=0.005), whereas EF(34±10 vs. 39±10%, P=0.03) and METS(from 7.44±1.84 to 8.78±2.72, P=0.03) increased. The mean cardiac PCr/ATP ratio was 1.35±0.33 with placebo, but was increased by 33%to 1.80±0.50(P=0.03)with trimetazidine. Conclusion: Trimetazidine improves functional class and LV function in patients with heart failure. These effects are associated to the observed trimetazidi ne-induced increase in the PCr/ATP ratio, indicating preservation of the myocar dial high-energy phosphate levels. | Fragasso G. Perseghin G. De Cobelli F. 苏畅(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，9： | 2 |
| 2 | Influence of treatment delay on long-left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty显示文摘 | Sheiban I Fragasso G Lu C | 2001 | Am Heart J2001，141，： | 1 |
| 3 | Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy显示文摘 | Fragasso G Piatti Md P M Monti L | 2003 | Am Heart J2003，146，5： | 1 |
| 4 | Coronary slow-flow causing transient myocardial hypoperfusion in patients with cardiac syndrome X: long-term clinical and functional prognosis 显示文摘 | Fragasso G Chierchia SL Arioli F | 2009 | Im J Cardiol2009，137，2： | 1 |
| 5 | Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure显示文摘 | Fragasso G Perseghin G De Cobelli F | 2006 | Eur Heart J2006，27，8： | 1 |
| 6 | Short-and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomypathy显示文摘 | Piatti Md PM Monti L | 2003 | Am Heart J2003，146，5： | 1 |
| 7 | The light of inflammation in the darkness of the coronary slow flow phenomenon 显示文摘 | Fragasso G Maranta F | 2013 | Anadolu Kardiyol Derg2013，13，1： | 1 |
| 8 | Myocardial iron overload assessed by magnetic resonance imaging(MRI)T2 * in multi-transfused patients with thalassemia and acquired anemias显示文摘 | Fragasso A Ciancio A Mannarella C | | 0，，01： | 1 |
| 9 | A randomized clinical trial of trimetazidine,apartial free fatty acid oxidation inhibitor,in patients with heart failure显示文摘 | Fragasso G Palloshi A Puccetti P | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 10 | Short and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyipaty显示文摘 | Fragasso G Piatt Md PM Mantil | | 0，，05： | 1 |
| 11 | A randomized clinical trial of trimetazidine,a partial free fatty acid oxidation inhibitor,in patients with heart failure显示文摘 | Fragasso G Palloshi A Puccetti P | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 12 | Time course and determinants of left ventricular function recovery after primary angioplasty in patients with AMI显示文摘 | Sheiban I Fragasso G Giuseppe MC | 2001 | JACC2001，38，2： | 1 |
| 13 | Effects of trimetazidine on ischemie left ventrieular dysfunction in patients with coronary artery disease显示文摘 | Lu C Dabrowski P Fragasso G | 1998 | Am J Cardiol1998，82，7： | 1 |
| 14 | A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure 显示文摘 | Fragasso G Palloshi A Puccetti P | 2006 | J Am Coll Cardiol2006，48，5： | 1 |
| 15 | Metabolic management of ischemic heartdisease显示文摘 | Chierchia SL Fragasso G | 1993 | Eur Heart J1993，14，： | 1 |
| 16 | Metabolic therapy of heart failure显示文摘 | Fragasso G Salerno A Spoladore R | 2008 | Curr Pharm Des2008，14，25： | 1 |
| 17 | Effect of partial inhibition of fatty acid oxidation by tfimetazidine on whole body energy me- tabolism in patients with chronic heart failure显示文摘 | Fragasso G Salerno A Lattuada G | 2011 | Heart2011，97，18： | 1 |
| 18 | Beneficial electrophysiological effects of trimetazidine in patients with post-ischemic chronic heart failure显示文摘 | Cera M Salerno A Fragasso G | 2010 | J Cardiovasc Pharmacol Ther2010，15，1： | 1 |
| 19 | Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease显示文摘 | Lu C Dabrowski P Fragasso G | 1998 | Am J Cardiol1998，82，7： | 1 |
| 20 | Coronary slow-flow causing transient myocardial hypoperfusion in patients with cardiac syndrome X: long-term clinical and ftmctional prognosis显示文摘 | Fragasso G Chierehia SL Atioli F | 2009 | Int J Cardio2009，137，2： | 1 |
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