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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | 大鼠中央杏仁核5-HT_3受体参与胸腺功能调制(英文)显示文摘本研究旨在探讨大鼠中央杏仁核(central amygdala,CeA)内5-HT3受体激动之后,对丝裂原刀豆球蛋白A(concanavalin A,ConA)刺激的胸腺细胞增殖反应的影响,及其潜在的神经内分泌调节环路。分别经大鼠腹腔(intraperitoneal,i.p.)、双侧侧脑室(intracerebroventricle,i.c.v.)和双侧CeA(intracentral amygdala,i.c.a.)注射选择性5-HT3受体激动剂1-phenylbiguanide(PBG),同时制备正常大鼠胸腺细胞悬液与不同浓度FBG(1×10-8~1×10-5mol/L)体外共同孵育。经MTT法测定显示,无论有无ConA刺激,正常大鼠离体胸腺细胞在与PBG(1×10-8~1×10-5mol/L)体外共同孵育时其增殖反应均不受后者影响;PBG i.p.(每天0.5 mg/kg,连续5 d)对ConA刺激的胸腺细胞的增殖反应亦无影响,而PBG i.c.v.(每天10μg/侧,连续5 d)则显著增强之;当PBG i.c.a.(每天1.0μg,侧,1 d或连续3、5、7 d)时,ConA刺激的胸腺细胞的增殖反应于给药后第1天即开始增强且日益显著,第5天达到高峰,第7天则趋于减弱。在给予PBG 5 min前相同给药部位先给予5-HT3受体拮抗剂tropisetron(TRP)预处理可逆转PBG的促胸腺细胞增殖效应。免疫组织化学SABC法检测显示,PBG(1.0μg/侧,i.c.a.)单次给药后各脑区可相继出现大量c-Fos阳性细胞(CeA:1 h;海马及皮层:1~2 h;下丘脑:4 h;中脑导水管周围灰质:8 h),并迅速达到各自高峰(CeA: 1 h;海马及皮层:2 h;下丘脑:4 h),与相应的生理盐水对照组及TRP预处理组相比均有显著性差异。随后,这一表达在各脑区中逐步减弱并消失(CeA:4 h;海马、皮层及下丘脑:8 h)。由此推论,大鼠CeA内5-HT3受体至少可部分通过边缘系统-皮层-下丘脑-中脑导水管周围灰质这一神经内分泌环路调制胸腺细胞功能。 | 徐民 陈伟强 王基平 David JR Foster 许德义 | 2007 | 生理学报2007，59，1： | 3 |
| 3 | Posterior cingulate metabolic changes occur in Parkinson' s disease patients without dementia显示文摘 | Camicioli RM Korzan JR Foster SL | 2004 | Neuosci Lett2004，354，3： | 1 |
| 4 | Morbidity and mortality after thyroidectomy 显示文摘 | | 1978 | Surg Gynecol Obstet1978，146，： | 1 |
| 5 | An engineering analysis of plastic wave propagation in the Taylor test显示文摘 | Jones S E Maudlin P J Foster Jr J C | 1998 | International Journal Impact Engineering1998，20，2： | 1 |
| 6 | Infection due to organisms of the mycobacterium fortuitum complex after augmentation mammaplasty:Clinical and epidemiologic features显示文摘 | Clegg HW Foster MT Sanders WE Jr | | 0，，： | 1 |
| 7 | Effect of narrow grassstrips on conservation reserve land converted to cropland 显示文摘 | Raffaelle Jr JB McGregor KC Foster GR | 1997 | Transactions of the ASAE1997，40，6： | 1 |
| 8 | Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132显示文摘 | Edbaner D Neilson JR Foster KA | 2010 | Neuron2010，65，3： | 1 |
| 9 | Posterior cingulated metabolic changes occur in Parkinson's disease patients without dementia 显示文摘 | Camicioli RM Korzan JR Foster SL | 2004 | Neurosci Lett2004，354，1： | 1 |
| 10 | Breast cancer and pregnancy显示文摘 | Foster RS Jr | 2000 | Sem in Oncol2000，27，4： | 1 |
| 11 | Towards an understanding of supply chain quality management 显示文摘 | Foster S T Jr | 2008 | Journal of Operations Manage- ment2008，26，4： | 1 |
| 12 | Sensitivity of embryonic rat dorsal root ganglia neurons to clostridium botulinum neurotoxins显示文摘 | Welch MJ Purkiss JR Foster KA | 2000 | Toxicon2000，38，2： | 1 |
| 13 | Isolation and characterization of Salmonella from broiler carcasses or parts 显示文摘 | Bokanyi R P Jr J F Stephens D N Foster | 1990 | Poult Sci1990，69，： | 1 |
| 14 | Differential induction of heat shock mRNA in oligodendrocytes, microglia, and astrocytes following hyperthermia显示文摘 | Foster JA Brown JR | 1997 | Mol Brain Res1997，45，2： | 1 |
| 15 | Staging of breast cancer: a new rationale for internal mammary node biopsy 显示文摘 | Morrow M Foster RS Jr | 1981 | Arch Surg1981，116，6： | 1 |
| 16 | Pemetrexed and gemcitabine for biliary tract and gallbladder carcinomas: a North Central Cancer Treatment Group (NccrG) phase I and II trial,N9943显示文摘 | Alberts SR Sande JR Foster NR | 2007 | J Gastroin?test Cancer2007，38，24： | 1 |
| 17 | A large community outbreak of salmonellosis caused by intentional contamination of restaurant salad bars显示文摘 | T6r6k TJ Tauxe RV Wise RP Livengood JR Sokolow R Mauvais S Birkness KA Skeels MR Horan JM Foster LR | 1997 | JAMA1997，278，5： | 1 |
| 18 | The interaction of bacterial pathogens with platelets显示文摘 | Fitzgerald JR Foster TJ Cox D | 2006 | Nat Rev Microbiol2006，4，6： | 1 |
| 19 | Centrilobular emphysema: CT-pathologic correlation 显示文摘 | Foster WL Jr Pratt PC Roggli VL | 1986 | Radiology1986，159，： | 1 |
| 20 | The effects of isosteviol against myocardium injury induced by ischaemia-reperfusion in the isolated Guinea pig heart 显示文摘 | Xu D Zhang S Foster D Jr | 2007 | Clin Exp Pharmacol Physiol2007，34，56： | 1 |
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