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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Comparing and contrasting the properties of urethane/acrylic hybrids with those of corresponding blends of urethane dispersions and acrylic emulsions显示文摘 | Brown R A Coogan R G Fortier D G | 2005 | Progress in Organic Coatings2005，52，： | 1 |
| 3 | Numerical simulation of the impacts of climate warming on a permafrost mound显示文摘 | guteau S Fortier R Delisle G | 2004 | Permafrost and Periglaeial Processes2004，15，： | 1 |
| 4 | Acute effects of short-duration isolated static stretching or combined with dy- namic exercises on strength,jump and sprint performance显示文摘 | FORTIER J LATTIER G BABAULT N | 2013 | Sci Sport2013，28，5： | 1 |
| 5 | Ectopic Pregnancy in a Cesarean Sear: a Case Report显示文摘 | Persadie R J Fortier AoStopps R G | 2005 | J Obstet Gynaecol Can2005，27，12： | 1 |
| 6 | Comparing and contrasting the properties of urethane/acrylic hybrids with those of corresponding blends of urethane dispersions and acrylic emulsions 显示文摘 | Brown R A Coogan R G Fortier D G | 2005 | Progress in Organic Coatings2005，52，： | 1 |
| 7 | Surface antigen of Toxoplasma gondii显示文摘 | Gouvrear G Sadak B Fortier B | 1988 | Parasitology1988，97，： | 1 |
| 8 | Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplenmented with exogenous insulin-like growth factor-1显示文摘 | Lust G Mohammed HO | 1999 | J Orthop Res1999，17，4： | 1 |
| 9 | Coordinate upregulation of cartilage matrix synthesis in fibrin cultures supplenmented with exogenous insulin-like growth factor- I 显示文摘 | Fortier LA Lust G Mohammed Ho | 1999 | J Orthop Res1999，17，4： | 1 |
| 10 | IFATS Collection:Using Human Adipose‐Derived Stem/Stromal Cells for the Production of New Skin Substitutes显示文摘 | Trottier V Marceau‐Fortier G Germain L | 2008 | Stem Cells2008，26，10： | 1 |
| 11 | Insulin-like growth factor-I enhances cell-based repair of articular cartilage 显示文摘 | Fortier L A Mohammed H O Lust G | 2002 | J Bone Joint Surg Br2002，84，2： | 1 |
| 12 | Associations among perceived autonomy support, forms of self-regulation, and persistence: A prospective study 显示文摘 | PELLETIER L G FORTIER M S VALLERAND R J | 2001 | MotivatEmot2001，25，4： | 1 |
| 13 | A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems显示文摘 | Fortier MA Krishnaswamy K Danyod G | 2008 | J Physiol Pharmacol2008，59，1： | 1 |
| 14 | Surface antigens of Toxoplasma gondii显示文摘 | Couvreur G Sadak A Fortier B | 1988 | Parasitology1988，97，1： | 1 |
| 15 | IF-ATS collection : Using human adipose - derived stem/stromal cells for the production of new skin substitutes 显示文摘 | TROTrlER V MARCEAU - FORTIER G GERMAIN L et 81 | 2008 | Stem Cells2008，26，10： | 1 |
| 16 | Insulin-like growth factor-I enhances cel-based repair of articular cartilage显示文摘 | Fortier LA Mohammed HO Lust G | | 0，，02： | 1 |
| 17 | Insulin-like growth factor-1 enhances cell-based repair of articular cartilage显示文摘 | Mohammed HO Lust G | 2002 | J Bone Joint Surg[Br]2002，84，2： | 1 |
| 18 | Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels 显示文摘 | Fortier S DeMaria R G Lamarche Y | 2004 | J Thorac Cardiovasc Surg2004，128，1： | 1 |
| 19 | Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1显示文摘 | Fortier LA Nixon AJ Lust G | | 0，，02： | 1 |
| 20 | A Postgenomic Integratred View of Prostaglandins in reproduction:implications for other body systems显示文摘 | Fortier MA Krishnaswamy K Danyod G | 2008 | J Physiol Pharmaeol2008，59，1： | 1 |
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