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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | 血管生成素样蛋白2水平与肾移植术后主动脉僵硬度和死亡率呈正相关显示文摘血管生成素样蛋白2(angiopoietin-like-2,ANGPTL2)是一种分泌性糖蛋白,可诱发血管内皮功能障碍、动脉粥样硬化和心血管病。循环ANGPTL2在慢性肾脏病(chronic kidney disease,CKD)患者中增加,加重患心血管病的风险。 | Desjardins MP Thorin-Trescases N Sidibé A Fortier C DeSerres SA Larivière R Thorin E Agharazii M 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 3 | Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimen- sional matrix 显示文摘 | WORSTER A A BROWER-TOLAND B D FORTIER L A | 2001 | J Orthop Res2001，19，4： | 1 |
| 4 | Comparing and contrasting the properties of urethane/acrylic hybrids with those of corresponding blends of urethane dispersions and acrylic emulsions显示文摘 | Brown R A Coogan R G Fortier D G | 2005 | Progress in Organic Coatings2005，52，： | 1 |
| 5 | Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells 显示文摘 | FORTIER L A NIXON A J WILLIAMS J | 1998 | Am J Vet Res1998，59，9： | 1 |
| 6 | Comparison between sys- temic analgesia, continuous wound catheter analgesia and contin- uous thoracic paravertebral block : a randomised, controlled trial of postthoracotomy pain management 显示文摘 | Fortier S Hanna HA Bernard A | 2012 | Eur J Anaesthesiol2012，29，11： | 1 |
| 7 | Prostaglandin E2 regulates both interleukin-2 and granulocyte-macrophage colonystimulating factor gene expression in bovine lymphocytes 显示文摘 | Emond V Fortier M A Murphy B D | 1998 | Biol Reprod1998，58，1： | 1 |
| 8 | The role of growth factors in cartilage repair显示文摘 | FORTIER L A BARKER J U STRAUSS E J | 2011 | Clin Orthop Relat Res2011，469，10： | 1 |
| 9 | Comparing and contrasting the properties of urethane/acrylic hybrids with those of corresponding blends of urethane dispersions and acrylic emulsions 显示文摘 | Brown R A Coogan R G Fortier D G | 2005 | Progress in Organic Coatings2005，52，： | 1 |
| 10 | Numerical analysis of a slider bearing with a heterogeneous slip/no slip surface显示文摘 | Salant R F Fortier A E | 2004 | Tribology Transactions2004，47，3： | 1 |
| 11 | Prostaglandin E2 regulates both interleukin-2 and granulocyte-macrophage colony-stimulating factor gene expression in bovine lymphocytes显示文摘 | EMOND V FORTIER M A MURPHY B D | 1998 | BiolReprod1998，58，1： | 1 |
| 12 | Osteoporosis in menopause 显示文摘 | Khan A Fortier M Reid R | 2014 | Obstet Gynaecol Can2014，36，9： | 1 |
| 13 | Insulin-like growth factor-I enhances cell-based repair of articular cartilage 显示文摘 | Fortier L A Mohammed H O Lust G | 2002 | J Bone Joint Surg Br2002，84，2： | 1 |
| 14 | Charaterization of a family of rhopty protein Toxop|asma tondii infection in mice 显示文摘 | Sadak A Taghy Z Fortier B Dubrementz JE | 1991 | J lmmunol1991，146，： | 1 |
| 15 | Numerical analysis of a journal bearing with a heterogeneous slip/no-slip surface 显示文摘 | FORTIER A E SALANT R F | 2005 | Journal of Tribology2005，127，4： | 1 |
| 16 | Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix显示文摘 | BROWER-TOLAND B D FORTIER L A | 2001 | J Orthop Res2001，19，4： | 1 |
| 17 | Vulnerability of marine fish larvae to the toxicdinoflagellate Protogonyaulax tamarensis显示文摘 | Gosselin S Fortier L Gagné J A | 1989 | Mar Ecol Prog Ser1989，57，1： | 1 |
| 18 | Surface antigens of Toxoplasma gondii显示文摘 | Couvreur G Sadak A Fortier B | 1988 | Parasitology1988，97，1： | 1 |
| 19 | Potential impact of a toxic dinoflagellate (Alexandrium excavatum) bloom on survival of fish and crustacean larvae显示文摘 | Robineau B Gagné J A Fortier L | 1991 | Marine Biology1991，108，2： | 1 |
| 20 | Numerical analysis of a slider bearing with a heterogeneous slip/no - slip surface 显示文摘 | Salant R F Fortier A E | 2004 | STLE Tribo Trans2004，47，： | 1 |
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