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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Dead-time compensation for ABR traffic control over ATM networks显示文摘 | Gomez S F Fornes J M Rubio F R | 2002 | Control Engineering Practice2002，10，5： | 2 |
| 4 | Discovery of novel inter- mediate forms redefines the fungal tree of life 显示文摘 | Jones M D M Forn I Gadelha C | 2011 | Nature2011，474，7350： | 1 |
| 5 | Acidity and stability of MCM-41 crystalline alluminosilicates显示文摘 | Corma A Fornes V Navarro M T | 1994 | J Catal1994，148，： | 1 |
| 6 | Treatment of HCV infection in patients with advanced cirrhosis显示文摘 | Forns X Navasa M Rodes J | 2004 | Hepatology2004，40，2： | 1 |
| 7 | Integrated morphophysiological assessment of two methods for sperm selection in bovine embryo productionin vitro显示文摘 | Cesari A Kaiser G G Mucci N Mutto A Vincenti A Fornes M W Alberio R H | | 0，，： | 1 |
| 8 | Substrate effect on the mechanical and tribological properties of arc plasma physical vapour deposition coatings显示文摘 | Picas J A Forn A Baile M T | 2005 | International Journal of Refractory Metals and Hard Materials2005，23，46： | 1 |
| 9 | Physical properties ofvarious coconut coir dusts compared to peat显示文摘 | Abad M Fornes F Carrion C' | 2005 | Hort Sci-ence2005，40，2： | 1 |
| 10 | Substrate effect on the mechanical and tribological properties of arc plasma physical vapour deposition coatings显示文摘 | Picas J A Forn A Baile M T | 2005 | International Journal of Refractory Metals and Hard Materials2005，23，： | 1 |
| 11 | Gold supported on a biopolymer (chitosan) catalyzes the regioselective hydroamination of alkynes显示文摘 | CORMA A CONCEPCION P DOMINGUEZ I FORNES V SABATER M J | 2007 | J Catal2007，251，1： | 1 |
| 12 | Study of nuclear decondensation of the rat spermatozoa by reducing agents during epididymal transit显示文摘 | Fornes M W Bustos-Obregon E | 1994 | Andrologia1994，26，2： | 1 |
| 13 | Aldo; condensations on solid catalysts: A cooperative effect between weak acid and base site 显示文摘 | Climent M J Fornes A C V Guil-Lopez R etal | 2002 | Adv Synth Catal2002，344，： | 1 |
| 14 | Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation显示文摘 | Forns X Garcia Retortillo M Serrano T | 2003 | J Hepatol2003，39，3： | 1 |
| 15 | V-containing MCM-41 and MCM-48 catalysts for the selective oxidation of propane in gas phase显示文摘 | PENA M L DEJOZ A FORNES V REY F VAZQUEZ M I LOPEZ NIETO J M | 2001 | Appl Catal A2001，209，12： | 1 |
| 16 | Preparation, Characterisation and Catalytic Actalytic Activity of ITQ-2, a Delaminated Zeolite显示文摘 | Corma A Fornes V Guil J M | 2000 | Microporous Mesoporous Mater2000，38，23： | 1 |
| 17 | Value of Serological Testing for Diagnosis of Legionellosis in Outbreak Patients显示文摘 | Rojas A Navarro M D Forn 6 s F E | 2005 | J Clin Microbiol2005，43，8： | 1 |
| 18 | Guidelines for au topsy investigation of sudden cardiac death显示文摘 | BASSO C BURKE M FORNES P | 2008 | Virchows Arch2008，452，1： | 1 |
| 19 | Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation 显示文摘 | Forns X Garcla-Retortillo M Serrano T | 2003 | J HepatoI2003，39，3： | 1 |
| 20 | On the influence of word rep- resentations for handwritten word spotting in historical document 显示文摘 | Llados J Rusinol M Fornes A et M | 2012 | International Journal of Pattern Recognition and Artificial Intelli- gence2012，26，5： | 1 |
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