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| 1 | Current and future pharmacological therapies for managing cirrhosis and its complications显示文摘Due to the restrictions of liver transplantation,complication-guided pharmacological therapy has become the mainstay of long-term management of cirrhosis.This article aims to provide a complete overview of pharmacotherapy options that may be commenced in the outpatient setting which are available for managing cirrhosis and its complications,together with discussion of current controversies and potential future directions.PubMed/Medline/Cochrane Library were electronically searched up to December 2018 to identify studies evaluating safety,efficacy and therapeutic mechanisms of pharmacological agents in cirrhotic adults and animal models of cirrhosis.Non-selective betablockers effectively reduce variceal re-bleeding risk in cirrhotic patients with moderate/large varices,but appear ineffective for primary prevention of variceal development and may compromise renal function and haemodynamic stability in advanced decompensation.Recent observational studies suggest protective,haemodynamically-independent effects of beta-blockers relating to reduced bacterial translocation.The gut-selective antibiotic rifaximin is effective for secondary prophylaxis of hepatic encephalopathy;recent small trials also indicate its potential superiority to norfloxacin for secondary prevention of spontaneous bacterial peritonitis.Diuretics remain the mainstay of uncomplicated ascites treatment,and early trials suggest alpha-adrenergic receptor agonists may improve diuretic response in refractory ascites.Vaptans have not demonstrated clinical effectiveness in treating refractory ascites and may cause detrimental complications.Despite initial hepatotoxicity concerns,safety of statin administration has been demonstrated in compensated cirrhosis.Furthermore,statins are suggested to have protective effects upon fibrosis progression,decompensation and mortality.Evidence as to whether proton pump inhibitors cause gut-liver-brain axis dysfunction is conflicting.Emerging evidence indicates that anticoagulation therapy reduces incidence and increases recanalisation rates of non-malignant portal vein thrombosis,and may impede hepatic fibrogenesis and decompensation.Pharmacotherapy for cirrhosis should be implemented in accordance with up-to-date guidelines and in conjunction with aetiology management,nutritional optimisation and patient education. | David Kockerling Rooshi Nathwani Roberta Forlano Pinelopi Manousou Benjamin H Mullish Ameet Dhar | 2019 | World Journal of Gastroenterology2019，25，8： | 16 |
| 2 | Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis显示文摘 | Angelo Andriulli Gioacchino Leandro Telemaco Federici Antonio Ippolito Rosario Forlano Angelo Iacobellis Vito Annese | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 3 | Serological prevalence of Babesiacaballi and Theileria equi in horses of Lara State, Venezuela 显示文摘 | Mujica F F Perrone T Forlano M | 2011 | Vet Parasitol2011，178，12： | 1 |
| 4 | Fatal systemic venous air embolism during endoscopic retrograde cholangiopancreatography显示文摘 | Bisceglia M Simeone A Forlano R | 2009 | Adv Anat Pathol2009，16，4： | 1 |
| 5 | Pancreatic duct stents in the prophylaxis of pancreatic damage after endoscopic retrograde cholangiopancreatography : a systematic analysis of benefits and associated risks 显示文摘 | Andriulli A Forlano R Napolitano G | 2007 | Digestion2007，75，23： | 1 |
| 6 | Pan-ereatic ductstents in the prophylaxis of pancreatic damage after endoscopic retrograde cholangiopancreat ography: asystematic analysis of benefits and associated risks 显示文摘 | ANDRIULLI A FORLANO R NAPOLITANO G | 2007 | Digestion2007，75，23： | 1 |
| 7 | Reading comprehension in the presence of unat- tended speech and music显示文摘 | MARTIN R WOGALTER M FORLANO J | 1988 | Journal of Memory and Language1988，，27： | 1 |
| 8 | Reading Comprehension in the Presence of Unattended Speech and Music显示文摘 | Martin R C Wogaher M S Forlano J G | 1988 | Journal of Memory and Language1988，27，4： | 1 |
| 9 | Effect of the BioEnterics intragastric balloon on weight, insulin resistance, and liver steatosis in obese patients显示文摘 | Rosario Forlano Antonio Massimo Ippolito Angelo Iacobellis Antonio Merla Maria Rosa Valvano Grazia Niro Vito Annese Angelo Andriulli | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 10 | Pancreatic duct stents in the prophylaxis of pancreatic damage after endoscopic retrograde cholangiopancreatography:a systematic analysis of benefits and asso- ciated risks 显示文摘 | Andriulli A Forlano R Napolitano G | 2007 | Digestion2007，75，23： | 1 |
| 11 | Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis显示文摘 | Angelo Andriulli Gioacchino Leandro Telemaco Federici Antonio Ippolito Rosario Forlano Angelo Iacobellis Vito Annese | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 12 | Pancreatic duct stents in the prophylaxis of pancreatic damage after endoscopic retrograde choiangiopanereatography: a systematic analysis of benefits and associated risks显示文摘 | Andriulli A Forlano R Napolitano G Conoscitore P Caruso N Pilotto A | 2007 | Digestion2007，75，23： | 1 |
| 13 | Biliary papillomatosis, case report显示文摘 | Forlano I Fersini A Tartaglia N | 2011 | Ann Ital Chir2011，82，5： | 1 |
| 14 | Pancreatic duct stents in the prophylaxis of pancreatic damage after endoscopic retrograde cholangiopancreatography:a systematic analysis of benefits and associated risks显示文摘 | Andriulli A Forlano R Napolitano G | | 0，，： | 1 |
| 15 | Pancreatic duct stents in trophylaxis of pancreatic damage after endoscopic retrograde cholangiopanereatography: a systematic analysisof benefits and associated risks 显示文摘 | Andriulli A Forlano R Napolitano G | 2007 | Digestion2007，75，： | 1 |
| 16 | Pancreatic duct stents in the prophylaxis of pancreatic damage after endo- scopic retrograde cholangiopancreatography:a systematic a- nalysis of benefits and associated risks 显示文摘 | Andriulli A Forlano R Napolitano G | 2007 | Digestion2007，75，23： | 1 |
| 17 | Biliary papil- lomatosis, case report显示文摘 | FORLANO I FERSINI A TARTAGLIA N | 2011 | Ann Ital Chir2011，82，5： | 1 |
| 18 | Effect of the Bioenterics intragastric balloon on weight,insulin resis-tance,and liver steatosis in obese patients显示文摘 | Forlano R Ippolito AM Iacobellis A | 2010 | Gastroin-test Endosc2010，71，66： | 1 |
| 19 | Fatal Systemic Venous Air Embolism During Endoscopic Retrograde Cholangiopancreatography显示文摘 | Michele Bisceglia Anna Simeone Rosario Forlano Angelo Andriulli Alberto Pilotto | 2009 | Advances in Anatomic Pathology2009，，4： | 1 |
| 20 | Elemental gas phase atmospheric mercury as it interacts with the ambient aerosol and its subsequent speciation and deposition 显示文摘 | FORLANO L HEDGECOCK I M PIRRONE N | 2000 | Sei Total Environ2000，259，123： | 1 |
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