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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Characterization of Metal Pollution in Soil under Two Landuse Patterns in the Angouran Region,NW Iran:a Study Based on Multivariate Data Analysis显示文摘 | Qishlaqi A Moore F Forghani G | 2009 | Journal of Hazardous Materials2009，172，： | 1 |
| 3 | Computational modeling of damage development in composite laminates subjected to transverse dynamic loading 显示文摘 | Forghani A Vaziri R | 2009 | Journal of Applied Mechanics2009，76，05： | 1 |
| 4 | Characterization of metalpollution in soils under two landuse patterns in the Angouranregion,NW Iran ; a study based on multivariate data analysis显示文摘 | Qishlaqi A Moore F Forghani G | 2009 | Journal of Hazardous Materialsf2009，172，1： | 1 |
| 5 | Ocular adnexal lymphoma: diffusion weighted mr imaging for differential diagnosis and therapeutic monitoring 显示文摘 | Politi L S Forghani R C Resti A G | 2010 | Radiology2010，256，2： | 1 |
| 6 | Multiobjective genetic algorithm conjunctive use optimization for production,cost,and energy with dynamic return flow显示文摘 | PERALTA R C FORGHANI A FAYAD H | 2014 | Journal of Hydrology2014，511，4： | 1 |
| 7 | Stability of a varicella-zoster virus glycoprotein E epitope显示文摘 | Vafai A Forghani B Kilpatrick D | 2000 | Arch Virol2000，145，1： | 1 |
| 8 | Impact of untreated wastewater irrigation on soils and crops in Shiraz suburban area, SW Iran显示文摘 | Qishlaqi A Moore F Forghani G | 2008 | Environ Monit Assess2008，141，13： | 1 |
| 9 | Current - sensing tech- niques for DC - DC converters 显示文摘 | FORGHANI Z H P RINCON M G A | 2002 | IEEE Midwest Symp on Circuits and Systems2002，，8： | 1 |
| 10 | Total concentration, speciation and mobility of potentially toxic elements in soils around a mining area in central Iran 显示文摘 | Forghani G Mokhtari A R Kazemi G A | 2015 | Chemie der Erde-Geochemistry2015，75，3： | 1 |
| 11 | The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features显示文摘 | Nagel MA Cohrs R J Mahalingam R Wellish MC Forghani B Schiller A | 2008 | Neurology2008，70，11： | 1 |
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