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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Structural characterization and strengthening mechanism of forsterite nanostructured scaffolds synthesized by multistep sintering method显示文摘In this study, highly porous forsterite scaffolds with interconnected porosities were synthesized using multi-step sintering(MSS) method. The starting powder was nanosized forsterite, which was synthesized from talc and magnesium carbonate powders. The phase composition, average particle size and morphology of the produced forsterite powder were characterized by X-ray diffraction technique(XRD) and transition electron microscopy(TEM). Forsterite scaffolds were produced by foamy method using polymeric sponges. MSS process including three steps was used to efficiently sinter the forsterite nanopowders without destroying the initial porous structure of polymeric sponges. The results showed that MSS technique is an efficient and appropriate procedure to produce highly porous forsterite scaffolds with pore size in the range of 100-300 μm. The compressive strength, compressive modulus and porosity of C12 specimen(sintered at 1650℃ for 1 h with subsequent annealing at 1000℃ for 1000 min) was 1.88 MPa, 29.2 MPa, and 72.4%, respectively, which is very close to that of cancellous bone. The approach studied in this research can be developed for other nanostructure ceramics to produce highly porous scaffolds with interconnected porosities for load bearing applications. | Fariborz Tavangarian Abbas Fahami Guoqiang Li Mohammadhassan Kazemi Anoosha Forghani | 2018 | Journal of Materials Science & Technology2018，34，12： | 3 |
| 3 | Characterization of Metal Pollution in Soil under Two Landuse Patterns in the Angouran Region,NW Iran:a Study Based on Multivariate Data Analysis显示文摘 | Qishlaqi A Moore F Forghani G | 2009 | Journal of Hazardous Materials2009，172，： | 1 |
| 4 | Computational modeling of damage development in composite laminates subjected to transverse dynamic loading 显示文摘 | Forghani A Vaziri R | 2009 | Journal of Applied Mechanics2009，76，05： | 1 |
| 5 | The venous distension sign: a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | Am J Neuroradiol2007，28，8： | 1 |
| 6 | A novel approach for considering layout problem in cellular manufacturing systems with alternative processing routings and subcontracting approach 显示文摘 | Mohammadi Mohammad Forghani Kamran | 2014 | Applied Mathematical Modelling2014，38，14： | 1 |
| 7 | The venous distension sign:a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | Am J Neuroradiol2007，28，8： | 1 |
| 8 | Characterization of metalpollution in soils under two landuse patterns in the Angouranregion,NW Iran ; a study based on multivariate data analysis显示文摘 | Qishlaqi A Moore F Forghani G | 2009 | Journal of Hazardous Materialsf2009，172，1： | 1 |
| 9 | Demyelinating disea-ses :myeloperoxidase as an imaging biomarker and therapeutic target显示文摘 | Forghani R Wojtkiewicz GR Zhang Y | 2012 | Radiology2012，263，2： | 1 |
| 10 | Ocular adnexal lymphoma: diffusion weighted mr imaging for differential diagnosis and therapeutic monitoring 显示文摘 | Politi L S Forghani R C Resti A G | 2010 | Radiology2010，256，2： | 1 |
| 11 | Analysis and measurements of iron loss and flux inside silicon steel laminations显示文摘 | Cheng Z Takahashi N Forghani B | 2009 | IEEE Trans on Magnetics2009，45，3： | 1 |
| 12 | Stress-induced subel inical reactivation of varicella zoster virus in astronauts显示文摘 | Mehta SK Cohrs RJ Forghani B | 2005 | J Med V irol2005，72，1： | 1 |
| 13 | Ocular adnexai lymphoma: diffusion-weighted MR imaging for differential diagnosis and therapeutic monitoring 显示文摘 | Politi LS Forghani R Godi | 2010 | Radiology2010，256，2： | 1 |
| 14 | Parameter optimization of improved fuzzy C-means clustering algorithm for brain MR image segmentation显示文摘 | FOROUZANFAR M FORGHANI N TESHNEHLAB M | 2010 | Engineering Applications of Artificial Intelligence2010，23，2： | 1 |
| 15 | The venous distension sign: a diagnostic sign of intracranial hypotension at MR imaging of the brain显示文摘 | Farb RI Forghani R Lee SK | 2007 | AJNR Am J Neuroradiol2007，28，8： | 1 |
| 16 | Ocular adnexal IymphomaJ dif?fusion-weighted mr imaging for differential diagnosis and thera?peutic monitoring显示文摘 | Politi LS Forghani R Godi | 2010 | Radiology2010，256，2： | 1 |
| 17 | A T-omega method u sin g hierarchal edge elements 显示文摘 | Webb J P Forghani B | 1995 | IEE Proc - Sci Meas Technol1995，142，2： | 1 |
| 18 | Analysis and measurements of iron loss and flux inside silicon steel laminations 显示文摘 | dCheng Z Takahashi N Forghani B | 2009 | IEEE Transactions on Magnetics2009，45，3： | 1 |
| 19 | Analysis and measurements of iron loss and flux inside silicon steel laminations 显示文摘 | Cheng Z Takahashi N Forghani B | 2009 | IEEE Transactions on Magnetics2009，45，3： | 1 |
| 20 | Current - sensing techniqu -es for DC-DC converters显示文摘 | Hassan Pooya Forghani - zadeh | 2002 | Midwest Syrup on Circuits Syst2002，，2： | 1 |
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