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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Small-scale Restoration in the High Arctic:a Long -term Perspective显示文摘 | FORBES B | 1993 | Restoration Ecology1993，，1： | 1 |
| 3 | Highly oriented and conducting ZnO: Ga layers grown by chemical spray pyrolysis 显示文摘 | Reddy K T R Reddy T B S Forbes I | 2002 | Surf Coat Technol2002，，1： | 1 |
| 4 | Adult lean body mass declines with age:some longitudinal observations显示文摘 | FORBES G B REINA J C | 1970 | Metab Clin Exp1970，19，9： | 1 |
| 5 | Potential role of nitric oxide in chromium-induced lung carcinogenesis显示文摘 | Forbes TA Hopkins L Schneider B | 2012 | Cancer Res2012，72，8： | 1 |
| 6 | An approach to targeted drug delivery based on uniform magnetic fields 显示文摘 | YELLEN B B BARBEE K A | 2003 | IEEE Transactions on Magnetics2003，39，5： | 1 |
| 7 | K-Ar studies in two deep basement drill holes: A new geological estimate of argon blocking for blobite显示文摘 | Turner D L Forbes R B | 1976 | Eos1976，57，： | 1 |
| 8 | Highly oriented and conducting ZnO:Ga layers grown by chemical spray pyrolysis 显示文摘 | Reddy K T R Reddy T B S Forbes I | 2002 | Surface and Coatings Technology2002，，1： | 1 |
| 9 | Dynamic Behavior of Com- plex Fluid-filled Tubing Systems Part 1 : Tubing Analysis 显示文摘 | FORBES T B STEPHEN C T | 2001 | Journal of Dynamic Systems Measurement and Con-trol2001，123，： | 1 |
| 10 | Isentropic compression loading of octahydro-1,3,5,7-tetranitro-1, 3,5,7-tetrazocine (HMX) and the pressure-induced phase transition at 27 GPa 显示文摘 | Hare D E Forbes J W Reisman D B | 2004 | Appl Phys Lett2004，85，6： | 1 |
| 11 | An approach to targeted drug delivery based on uniform magnetic fields显示文摘 | FORBES I G YELLEN B B BARBEE | 2003 | Magnetics2003，39，： | 1 |
| 12 | Total exudative retinal detachment in Coats disease biochemical analysis of the subretinal exudate 显示文摘 | Hsu J Forbes B Maguire AM | 2006 | J Retin Vitr Dis2006，26，7： | 1 |
| 13 | Energy expenditure under free-living conditions in normal-weight and overweight women显示文摘 | Welle S Forbes C B Start M | 1992 | Am J Clin Nutr1992，55，1： | 1 |
| 14 | Prospects for stem cell transplantation in the treatment of hepatic disease显示文摘 | STUTCHFIELD B M FORBES S J WIGMORE S J | 2010 | Liver Transpl2010，16，7： | 1 |
| 15 | Use of skeletal muscle MRI in diagnosis and monitoring disease progression in duchenne muscular dystrophy显示文摘 | Finanger EL Russman B Forbes SC | 2012 | Phys Med Rehabil Clin N Am2012，23，1： | 1 |
| 16 | Lean body mass in obesity 显示文摘 | FORBES G B WELLES L | 1983 | Int J Obes1983，7，2： | 1 |
| 17 | Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy 显示文摘 | Chevalier R L Forbes M S Thornhill B A | 2009 | Kidney Int2009，75，11： | 1 |
| 18 | Adaptive resistance to benzalkonium chloride, amikacin and tobramycin: the effect on susceptibility to other antimicrobials显示文摘 | Joynson JA Forbes B Lambert RJW | 2002 | Journal of Applied Microbiology2002，93，1： | 1 |
| 19 | Evaluation and Management of a Pre- mature Infant's Eyes 显示文摘 | Forbes B J Khazaeni LM | 2003 | Pediatr Case Rev2003，3，2： | 1 |
| 20 | Diamond and hard carbon films for microelectromechanical systems (MEMS) : A nanotribological study显示文摘 | Forbes I S John I B | 2002 | Thin Solid Films2002，，： | 1 |
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