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| 1 | Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis显示文摘AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. | Melchiorre Cervello Daniela Foderà Ada Maria Florena Maurizio Soresi Claudio Tripodo Natale D'Alessandro Giuseppe Montalto | 2005 | World Journal of Gastroenterology2005，11，30： | 21 |
| 2 | An efficient protein complex purification method for functional proteomics in higher eukaryotes显示文摘 | Foder D Kocher T Rode M | 2003 | Nat Biotechnol2003，21，1： | 1 |
| 3 | Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxy-genase-2 inhibitors in humanhepatic cancer cells by inhibition of the MEK/ERK pathway显示文摘 | Cusimano A Foder D D'Alessandro N | 2007 | Cancer Biol Ther2007，6，9： | 1 |
| 4 | Prostaglandin E2 receptors and COX enzymes in human hepatocelluar carcinomar:role in the regulation of cell growth显示文摘 | Cusimano A Fodere D Lampiasi N | 2009 | Ann N Y Acad Sci2009，1155，1： | 1 |
| 5 | The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells显示文摘 | Lampiasi N Foderà D D'Alessandro N | | 0，，02： | 1 |
| 6 | Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway显示文摘 | Cusimano A Foderà D D′Alessandro N | 2007 | Cancer Biol Ther2007，6，9： | 1 |
| 7 | Induction of apoptosis and inhibition of cell growth in human hepatocular carcinoma cells by COX-2 inhibitors显示文摘 | Foder D Dalessandro N Cusimano A | 2004 | Ann N Y Acad Sci2004，1028，14： | 1 |
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