|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | Immunomodulatory effects of lactoferrin显示文摘Lactoferrin (Lf ) 是 transferrin 家庭的铁绑定 glycoprotein,它在很生物的液体被表示与在哺乳动物的牛奶特别地高级。它的多重活动在它的能力躺着绑铁并且与主人和病原体的分子、细胞的部件交往。Lf 能绑并且扣押 lipopolysaccharides,因此阻止的支持 inflammatory 小径激活,败血和织物损坏。Lf 也被认为衔接天生、适应的有免疫力的回答的一个藏匿房间的调停人。在最近的年里,大部分被了解了 Lf 由施加它的活动的机制。这评论在理解位于 Lf 的多功能的角色下面的机制总结最近的进展,并且在它的潜在的预防、治疗学的应用上提供一个未来观点。 | Tania SIQUEIROS-CENDON Sigifredo AREVALO-GALLEGOS Blanca Flor IGLESIAS-FIGUEROA Isui Abril GARCiA-MONTOYA Jose SALAZAR-MARTIN EZ Quintin RASCON-CRUZ | 2014 | Acta Pharmacologica Sinica2014，35，5： | 8 |
| 3 | Underlying mechanism of the hydrothermal instability of Cu3(BTC)2 metal-organic framework显示文摘水导致了 Cu 3(BTC)2(BTC = benzene-1,3,5-tricarboxylate ) 的分解金属器官的框架(MOF ) 用动态水被学习蒸汽吸附。散布的小角度的 X 光检查,红外线的光谱学和微分扫描热量测定分析的 Fourier 变换表明在潮湿的溪流下面的 Cu 3(BTC)2 MOF 分解的内在的机制是进 Cu-BTC 协作的水分子的互相贯通从 Cu 中心代替器官的连接器(BTC ) 。 | Nadeen AI-Janabi Abdullatif Alfutimie Flor R. Siperstein Xiaolei Fan | 2016 | Frontiers of Chemical Science and Engineering2016，10，1： | 7 |
| 4 | The ATAF1 transcription factor: At the convergence point of ABA-dependent plant defense against biotic and abiotic stresses显示文摘 | Brigitte Mauch-Mani Victor Flors | 2009 | Cell Research2009，19，12： | 7 |
| 5 | Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells显示文摘Mesenchymal stem cells(MSCs)are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing.MSC-based treatments are generally considered a safe procedure,however,the long-term results obtained up to now are far from satisfactory.The main causes of these therapeutic limitations are inefficient homing,engraftment,and osteogenic differentiation.Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells.Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation.These strategies could range from a simple modification of the culture conditions,known as cell-preconditioning,to the genetic modification of the cells to avoid cellular senescence.Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation,mainly by the use of bioactive or biomimetic scaffolds,although alternative approaches will also be discussed.This review aims to summarize several of the most recent approaches,providing an up-to-date view of the main developments in MSCbased regenerative techniques. | Daniel García-Sánchez Darío Fernández JoséC Rodríguez-Rey Flor M Pérez-Campo | 2019 | World Journal of Stem Cells2019，11，10： | 4 |
| 6 | Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines显示文摘Objective: To evaluate the cytotoxic effects of Spirulina platensis extracts on acute leukemia Kasumi-1 and chronic leukemia K-562 cancer cell lines.Methods: Various concentrations of Spirulina platensis extracts(0.25–50.00 mg/m L)obtained with different solvents were used to treat cell lines for 72 h. For cytotoxic effect studies, cell viability test with trypan blue solution, MTT assay and microscopic cytomorphological assessment were done.Results: Spirulina extract obtained with 70% ethanol showed significant cytotoxicity in K562 and Kasumi-1 cell lines. With trypan blue solution, IC_(50) values were found to be4.64 mg/m L for K-562 and 3.68 mg/m L for Kusumi-1 cell lines. Spirulina aqueous extract also showed cytotoxicity with trypan blue method, at a slightly higher dose; where IC_(50) values were 12.68 mg/m L for K-562 and 2.13 mg/m L for Kusumi-1 cell lines. The IC_(50) values were found 0.40 mg/m L for K-562 and 0.31 mg/m L for Kusumi-1 cell lines for the 70% ethanol extract according to the MTT assay. Spirulina extract obtained with water also showed cytotoxicity but the dose was a little higher where IC_(50) values were15.77 mg/m L for K-562 and 9.44 mg/m L for Kusumi-1 cell lines. The effect of cytotoxicity with ethanol extract is quite comparable with that observed for cyclophosphamide, which is a chemical used as anticancer agent.Conclusions: The cytotoxicity exhibited by Spirulina extract to cancer cell lines might be due to the presence of phytopigments(carotenoids, chlorophyll, phycocyanin) as well as polysaccharides that were reported previously as constituents of the extract. So crude extracts of Spirulina can be used as a source to develop anticancer drugs. | Flor Yohana Flores Hernandez Sanghamitra Khandual Inocencia Guadalupe Ramírez López | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，1： | 4 |
| 7 | Current Status of the Gene-For-Gene Concept显示文摘 | H H Flor | 1971 | Annual Review of Phytopathology1971，，： | 3 |
| 8 | Bile duct injury during laparoscopic cholecystectomyrid=''显示文摘 | J. Calvete L. Sabater B. Camps A. Verdú A. Gomez-Portilla J. Martín M. A. Torrico B. Flor N. Cassinello S. Lledó | 2000 | Surgical Endoscopy2000，，7： | 2 |
| 9 | Complementary genetic system in flax of recombination values in heredity显示文摘 | Flor H H | 1956 | Adv Genet1956，8，： | 2 |
| 10 | Simulation Tools for a Fiber-Optic Based Structural Health Monitoring System显示文摘Probability of detection(POD)graphics allow for a change from qualitative to quantitative assessment for every damage detection system,and as such it is a main request for conventional non-destructive testing(NDT)techniques.Its availability can greatly help towards the industrialization of the corresponding Structural health monitoring(SHM)system.But having in mind that for SHM systems the sensors are at fixed positions,and the location of a potential damage would change its detectability.Consequently robust simulation tools are required to obtain the model assisted probability of detection(MAPOD)which is needed to validate the SHM system.This tool may also help for the optimization of the sensor distribution,and finally will allow a probabilistic risk management.INDEUS,simulation of ultrasonic waves SHM system,was a main milestone in this direction.This article deals with the simulation tools for a strain based SHM system,using fiber optic sensors(FOS).FOS are essentially strain/temperature sensors,either with multi-point or with distributed sensing.The simulation tool includes the finite element model(FEM)for the original and damaged structure,and algorithms to compare the strain data at the pre-established sensors locations,and from this comparison to extract information about damage occurrence and location.The study has been applied to the structure of an all-composite unmanned aircraft vehicle(UAV)now under construction,designed at Universidad Politecnica de Madrid for the inspection of electrical utilities networks.Distributed sensing optical fibers were internally bonded at the fuselage and wing.Routine inspection is planned to be done with the aircraft at the test bench by imposing known loads.From the acquired strain data,damage occurrence may be calculated as slight deviations from the baselines.This is a fast inspection procedure without requiring trained specialists,and it would allow for detection of hidden damages.Simulation indicates that stringer partial debondings are detected before they become critical,while small delaminations as those produced by barely visible impact damages would require a prohibited number of sensing lines.These simulation tools may easily be applied to any other complex structure,just by changing the FEM models.From these results it is shown how a fiber optic based SHM system may be used as a reliable damage detection procedure. | Alfredo Güemes Antonio Fernandez-Lopez Jaime García-Ramírez Maria Eugenia Reyes-Perez Flor Criado Zurita | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，2： | 2 |
| 11 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 12 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 13 | Early Prediction of Anastomotic Leak in Colorectal Cancer Surgery by Intramucosal pH显示文摘 | Monica Millan M.D. Ph.D. Eduardo García-Granero M.D. Ph.D. Blas Flor M.D. Ph.D. Stephanie García-Botello M.D. Salvador Lledo M.D. Ph.D | 2006 | Diseases of the Colon & Rectum2006，，5： | 2 |
| 14 | Vertical array growth of small diameter single-walled carbon nanotubes显示文摘 | Xu Y Q Flor E Kim J M | 2006 | Journal of the American Chemical Society2006，128，： | 1 |
| 15 | NdCoO3 perovskite as possible candidate for CO-sensors:thin films synthesis and sensing properties显示文摘 | Malavasi L Tealdi C Flor G Chiodelli G Cervetto V Montenero A Borella M | | 0，，02： | 1 |
| 16 | The complementary genie systems in flax and flaxrust显示文摘 | Flor H H | 1956 | Adv Genetics1956，8，： | 1 |
| 17 | A Model-View-Controller Extension for Pervasive Multi-client User Interfaces显示文摘 | Sauter P Specht G Flor T | 2005 | Personal Ubiquitous Computing2005，，9： | 1 |
| 18 | Coloplus, a new product based on bovine colostrum, alleviates HIV-associated diarrhea显示文摘 | Florén CH Chinenye S Elfstrand L | 2006 | Scand J Gastroenterol2006，41，6： | 1 |
| 19 | Throughput of Strongly Interfering Slow Frequency-Hopping Networks显示文摘 | redrik Florén etc | 2004 | IEEE transactions on communications2004，52，7： | 1 |
| 20 | Modelling mieroclimate in urban environments and assessing its influence on the performance of surrounding buildings 显示文摘 | Flor F S Dominguez S A | 2004 | Energy and Buildings2004，36，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员