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| 1 | Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBM显示文摘 | Muller S Schaffer T Flogerzi B | 2006 | Inflamm Bowel Dis2006，12，7： | 1 |
| 2 | Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD显示文摘 | MULLER S SCHAFER T FLOGERZI B | 2006 | Inflamm Bowel Dis2006，12，7： | 1 |
| 3 | Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD显示文摘 | Muller S Schaffer T Flogerzi B | 2006 | Inflamm Bowel Dis2006，12，7： | 1 |
| 4 | Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn' s disease 显示文摘 | Seibold F Konrad A Flogerzi B | 2004 | Gastroenterology2004，127，4： | 1 |
| 5 | Low Mannan-binding lecfin serum levels are associated with complicated Crohn's disease and reactivity to oligomannan (ASCA)显示文摘 | SCHOEPFER AM FLOGERZI B SEIBOLD-SCHMID B | 2009 | Am J Gas- troenterol2009，104，10： | 1 |
| 6 | Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease显示文摘 | Seibold F Konrad A Flogerzi B | | 0，，4： | 1 |
| 7 | Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn's patients and are not inducible in murine models of colitis显示文摘AIM: To investigate ASCA production over time in CD and murine colitis in order to further our understanding of their etiology.MATERIALS AND METHODS: Sixty-six CD patients were compared to ulcerative colitis (UC) and irritable bowel syndrome patients with respect to ASCA production as measured by ELISA. ASCA IgG or IgA positivity as well as change in titers over a period of up to 3 years (ΔIgG/A) was correlated with clinical parameters such as CD activity index (CDAI) and C-reactive protein levels (CRP). Moreover, two murine models of colitis (DSS and IL-10 knock out) were compared to control animals with respect to ASCA titers after oral yeast exposure.RESULTS: ASCA IgG and IgA titers are stable over time in CD and non-CD patients. Fistular disease was associated with a higher rate of ASCA IgA positivity (P = 0.014). Ileal disease was found to have a significant influence on the ΔIgG of ASCA (P=0.032). There was no correlation found between ASCA positivity or ΔIgG/A and clinical parameters of CD: CDAI and CRP. In mice,neither healthy animals nor animals with DSS-induced or spontaneous colitis exhibited a marked increase in ASCA titers after high-dose yeast exposure. On the other hand, mice immunized intraperitoneally with mannan plus adjuvant showed a marked and significant increase in ASCA titers compared to adjuvant-only immunized controls (P=0.014).CONCLUSION: The propensity to produce ASCA in a subgroup of CD patients is largely genetically predetermined as evidenced by their stability and lack of correlation with clinical disease activity parameters. Furthermore,in animal models of colitis, mere oral exposure of mice to yeast does not lead to the induction of marked ASCA titers irrespective of concomitant colonic inflammation.Hence, environment may play only a minor role in inducing ASCA. | Stefan Müller Maya Styner Beatrice Seibold-Schmid Beatrice Flogerzi Michael M(a|¨)hler Astrid Konrad Frank Seibold | 2005 | World Journal of Gastroenterology2005，11，44： | 1 |
| 8 | Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD显示文摘 | Muller S Schaffer T Flogerzi B | 2006 | Inflamm Bowel Dis2006，12，7： | 1 |
| 9 | Anti-Saccharomyces cerevisiae man- nan antibodies (ASCA) of Crohn' s patients crossreact with mannan from other yeast strains, and murine ASCA IgM can be experimentally induced with Candida albicans显示文摘 | Schaffer T Miiller S Flogerzi B | 2007 | Inflamm Bowel Dis2007，13，11： | 1 |
| 10 | Genetic variants of the mannan - binding lectin are associated with immune reactivity to mannans in Crohn ''s disease 显示文摘 | Seibold F Konrad A Flogerzi B | 2004 | Gastroenterology2004，127，4： | 1 |
| 11 | Comparison of interferon-gamma release assay versus tuberculin skin test for tuberculosis screening in inflammatory bowel disease显示文摘 | Schoepfer A M Flogerzi B Fallegger S | 2008 | Am J Gastroenterol2008，103，11： | 1 |
| 12 | Galectin-3modulatesT cell activity and is reduced in the inflamed intestinal epithelium in IBD显示文摘 | Muller S Schaffer T Flogerzi B | 2006 | Inflamm Bowel Dis2006，12，7： | 1 |
| 13 | Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithe liuminIBD显示文摘 | Mtiller S Schaffer T Flogerzi B | 2006 | InflammBowelDis2006，12，7： | 1 |
| 14 | Anti-Saccharomycescerevisiae mannan antibodies (ASCA) of Crohn's patients crossreaet with mannan from other yeast strains, and murine ASCA IgM can be experimentally induced with Candida albicans显示文摘 | Schaffer T Mtiller S Flogerzi B | 2007 | Inflamm Bowel Dis2007，13，11： | 1 |
| 15 | 甘露聚糖结合凝集素遗传变异体与克罗恩病患者对甘露聚糖的免疫反应有关 | Seibold F. Konrad A. Flogerzi B. 王志宇 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，3： | 0 |
| 16 | Tibetan herbal formula Padma Digestin modulates gastrointestinal motility in vitro显示文摘AIM:To examine the effects of Padma Digestin on the smooth muscle motility of different gastrointestinal segments in vitro . METHODS:The effects of the ethanolic extract of Padma Digestin (at 8.16 mg/mL or 81.6mg/mL) on the contractility and susceptibility to acetylcholine (ACh) of muscle strips from the cardia, antrum, pylorus, duodenum, jejunum, ileum and colon of male Wistar rats were analyzed.RESULTS:Compared with the control treatment, the Padma Digestin extract had a procontractile effect on the antral smooth muscle strips. Padma Digestin decreased ACh sensitivity in cardia muscle strips and increased it in those from the antrum and pylorus. In the intestinal segments, spontaneous contractility was inhibited in both the duodenal and jejunal strips, whereas reactivity to ACh was inhibited in the jejunal strips only. In the colonic samples, Padma Digestin inhibited spontaneous and ACh-stimulated contractility at a low dose but seems to have increasing effects at a high dose. CONCLUSION:Padma Digestin extract has regionspecific effects on the contractility and excitability of gastrointestinal smooth muscle. Our results support the traditional use of Padma Digestin for maldigestion and functional gastrointestinal disorders. | Bruno M Balsiger Magali Krayer Andreas Rickenbacher Beatrice Flogerzi Cecile Vennos Juergen M Gschossmann | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，1： | 0 |
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