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| 1 | Comparison of Wirsung-jejunal duct-tomucosa and dunking technique for pancreatojejunostomy after pancreatoduodenectomy显示文摘Pancreato-enteric reconstruction after pancreatoduodenectomy (PD) is still a source of debate because of the high incidence of complications. Among the various types of pancreato-jejunostomies we don’t know yet which is the best in terms of anastomotic failure and related complications rates. Wirsung-jejunal duct-to-mucosa anastomosis (WJ) and 'dunking' pancreato-jejunal anastomosis (DPJ) are the two most used ones worldwide but conflicting results are reported. To determine which is the safer anastomosis and to define when an anastomosis should be preferred, we retrospectively reviewed two groups of patients who underwent WJ or DPJ. METHODS:Twenty-three patients underwent PD with WJ (n=17) with dilated (WJD) (n=9) or not-dilated Wirsung’s duct (WJND) (n=8) or with a DPJ (n=6) over a 3-year period at a single institution. RESULTS: The complications rate was high in all groups of patients (33.3% in WJD, 37.5% in WJND and 66.7% in DPJ). A pancreatic fistula developed in one patient in each group (11. 1% in WJD, 12. 5% in WJND and 16. 7% in DPJ). All these patients were managed conservatively. Anastomotic disruption took place in the WJ patients especially in the WJND group (n=2) compared to the WJD (n=1) (25% vs 11.1%) or DPJ groups (0%) : these three patients required a re-operation. Overall, the anastomotic defects were higher in patients who underwent WJND (37.5%), compared to WJD (22.2%) and to DPJ (16.7%). However, no statistical differences were found among the groups. Delayed gastric emptying (DGE) and total parenteral nutrition (TPN) along with anastomotic defects were responsible for a prolonged hospital stay. CONCLUSIONS:Our results were not able to demonstrate any statistical difference between the two different techniques in preventing anastomotic failure. WJ can represent a valid choice in case of a dilated duct and a firm, fibrotic enlarged gland that could not be properly invaginated in a small jejunal loop. DGE may occur in those patients who experienced an anastomotic failure and required a TPN regimen with a prolonged hospital stay. | Unita di Chirurgia, Dipartimento di Fisiopatologia Clinica (Batignani G, Fratini G, Zuckermann M and Tonelli F) and Dipartimento di Statistica (Bianchini E), Universitd degli Studi di Firenze, Flo rence, Italy | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 2 | Deprescribing antihypertensive treatment in nursing home patients and the effect on blood pressure显示文摘BackgroundIt 是可争辩的与 antihypertensive 药对待 multimorbid 疗养院病人是否生产有益的效果。最心血管的指南支持治疗;很少有上的忠告到 deprescribe 当治疗可能不再是必要的时。我们在在认知,血压,和 prescribing.MethodsFrom 2014年8月之间的 antihypertensive 药使用和协会上调查了药评论的效果到2015年12月,来自在 32 所挪威的疗养院的 72 个单位(簇)的 765 个病人被包括在一4月, multicentre ,使随机化簇的、控制试用,与9月的后续。病人们有 antihypertensive 治疗的 65 岁(n = 295, 39%) 被使随机化到医生从同伴(启蒙的 collegial ) 得到了支持或象往常一样被给照顾的系统的药评论(控制条件) 。结果措施是 antihypertensive 药,收缩血压,和脉搏的数字。我们把住院和死亡用作标准估计 harm.ResultsAt 基线,每个病人使用了 9.2 吗?? | Christine Gulla Elisabeth Flo Reidun LS Kjome Bettina S Husebo | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 3 | Laparoscopic methotrexatetreat- ment of ectopic pregnancy : feasibility, efficacy, safety andintra- uterine pregnancy rates 显示文摘 | Flo K Bremnes RM Mahau JM | 2000 | J Obstet Gynaecol2000，20，3： | 1 |
| 4 | Involvement of toll-like receptor(TLR)2 and TLR4 in cell activation by mannuronic acid polymers 显示文摘 | Flo T H Ryan L Latz E | 2002 | J Biol Chem2002，277，35： | 1 |
| 5 | Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaecharide 显示文摘 | Flo T H Halaas O Lien E | 2000 | Immunol2000，164，4： | 1 |
| 6 | Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers显示文摘 | Flo T H | 2002 | J Biol Chem2002，277，35： | 1 |
| 7 | Differential expression of Toll-like receptor2 in humancells显示文摘 | Flo TH Halaas O Torp S | 2001 | J Leukoc Biol2001，69，3： | 1 |
| 8 | Differential expression of Toll-like receptor 2 in human cells显示文摘 | Flo TH Halaas O Torp S | 2001 | J Leukoc Biol2001，69，3： | 1 |
| 9 | Simulondsin:effects on meal patterns and choice behavior in rats 显示文摘 | Lievens S Flo G Deeuypere E et 01 | 2003 | Physiol Behav2003，78，45： | 1 |
| 10 | The vagus nerve is involved in the anorexigenie effect of simmondsin in tha rat显示文摘 | Flo G van Boven M Vermaut S eta/ | 2000 | Appetite2000，34，2： | 1 |
| 11 | Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron显示文摘 | Flo TH Smith KD Sato S | 2004 | Nature2004，432，7019： | 1 |
| 12 | The Toxicity to Clarias Lazera of Copper and Zinc Applied Jointly显示文摘 | Tort L Torres P Flos R | 1987 | Comp Biochem Physiol C1987，87，2： | 1 |
| 13 | Differential expression of Toll-like receptor 2 in human cells 显示文摘 | Flo TH Halaas 0 Torp S | 2001 | J Leukoc Biol2001，69，： | 1 |
| 14 | Mammalian achaete-scute homolog 1 is re- quired for the early development of olfactory and autonomic neurons 显示文摘 | Guillemot FLo LC | 1993 | Cell1993，75，3： | 1 |
| 15 | Impact of ezetimibe coadministered with statins on cardiovascular events following acute coronary syndrome; a 3-year population-based retrospective cohort study in Taiwan显示文摘 | Lin CF Gau CS Wu FLo | 2011 | Clin Ther2011，33，9： | 1 |
| 16 | Differeneial expression of Toll-like receptor2 in humancells显示文摘 | Flo TH Halaas O Torp S | 2001 | J Leukoc Biol2001，69，3： | 1 |
| 17 | Lipocalin 2 mediates an in-nate immune response to bacterial infection By sequestrating i ron显示文摘 | Flo TH Smith KD Sato S | 2004 | Nature2004，432，91： | 1 |
| 18 | Comparison of two stunning/slaughtering methods on stress response and quality indicators of European sea bass ( Dicentrarchus labrax )显示文摘 | L. Acerete L. Reig D. Alvarez R. Flos L. Tort | 2008 | Aquaculture2008，，1： | 1 |
| 19 | Lipoealin 2 mediates an innate immune response to bacterial infection by sequestrating iron 显示文摘 | Flo TH Smith KD Sato S | 2004 | Nature2004，432，7019： | 1 |
| 20 | Modification of the feeding be-havior of sole(Solea solea)through the addition of a commer-cial flavor as an alternative to belaine显示文摘 | Keig U Ginovart M Flos R | 2003 | Aqualic Living Re-sources2003，，16： | 1 |
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