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| 1 | Increased apoptosis, changes in intracellular Ca2+, and functional alterations in lymphocytes and macrophages after in vitro exposure to static magnetic field显示文摘 | Flipo D Fournier M Benquet C | 1998 | J Toxicol Environ Health A1998，54，1： | 1 |
| 2 | Early rheumatoid arthritis:A review of MRI and sonographic findings显示文摘 | Boutry N Morel M Flipo RM | | 0，，06： | 1 |
| 3 | Use of high resolution computed tomography of the lungs in patients with rheumatoid arthritis显示文摘 | Cortet B Flipo RM R6my-Jardin M | 1995 | Ann Rheum Dis1995，54，0： | 1 |
| 4 | Use of high resolution computed tomography of the lung in patients with rheumatoid arthritis显示文摘 | Cortet B Flipo RM Remy-Jardin M | 1995 | Ann Rheum Dis1995，54，： | 1 |
| 5 | Use of high resolution computed tomography of the lungs in patients with rheumatoid arthritis显示文摘 | Cortet B Flipo RM Remy-Jardin M | 1995 | Ann Rheum Dis1995，54，： | 1 |
| 6 | Patient knowledge of their disease:a French multicenter study in ankylosing spondylitis 显示文摘 | Claudepierre P Flipo RM Sibilia J | 2004 | Joint Bone Spine2004，71，6： | 1 |
| 7 | Management of nontuberculous infectious discitis, treatments used in 110 patients admitted to 12 teaching hospitals in France 显示文摘 | Legrand E Flipo RM Guggenbuhl P | 2001 | Joint Bone Spine2001，68，： | 1 |
| 8 | Service Firms:Interdependence of External and Internal Marketing Strategies显示文摘 | Jean-Paul Flipo | 1986 | European Journal of Marketing1986，，8： | 1 |
| 9 | Percutaneous vertebroplasty with acrylic cement in the treatment of a langerhans - cell vertebral histiocytosis 显示文摘 | Cardon T Hachulla E Flipo RM | 1994 | Clin Rheumatol1994，13，3： | 1 |
| 10 | Early rheumatoid arthritis and its differentiation from other joint abnormalities 显示文摘 | BOUTRY N DO CARMO CC FLIPO RM | 2009 | Eur J Radiol2009，71，2： | 1 |
| 11 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 12 | Early rheumatoid arthritis and its differentiation from other joint abnormalities 显示文摘 | BOUTRY N DO CARMO CC FLIPO RM | 2009 | Eur J Radiol2009，71，2： | 1 |
| 13 | Increased apoptosis,changes in intracellular Ca^2+,and functional alterations in lymphocytes and macrophages after in vitro exposure to static magnetic field显示文摘 | Flipo D Fournier M Benquet C | 1998 | J Toxicol Environ Health A1998，54，1： | 1 |
| 14 | Tuberculosis:thedrug development pipeline at a glance 显示文摘 | Villemagne B Crauste C Flipo M | 2012 | Eur J MedChem2012，51，1： | 1 |
| 15 | Modelling the impacts of combined sewer overflows on the river Seine water quality显示文摘 | Even S Mouchel J M Servais P Flipo N Poulin M Blanc S Chabanel M Paffoni C | | 0，，1： | 1 |
| 16 | Early rheumatoid arthritis:A review of MRI and sonographic findings显示文摘 | Boutry N Morel M Flipo RM | 2007 | Am J Roentgenol2007，189，6： | 1 |
| 17 | Patient knowledge of their disease:a French multicenter study in ankylosing spondylitis显示文摘 | Claudepierre P Flipo RM Sibilia J | 2004 | Joint Bone Spine2004，71，6： | 1 |
| 18 | Synovial haemangioma of the knee: a frequently misdiagnosed lesion 显示文摘 | Cotten A Flipo RM Herbaux B | 1995 | Skeletal Radiol1995，24，： | 1 |
| 19 | Early rheumatoid arthritis:A review of MRI and sonographic findings显示文摘 | Boutry N Morel M Flipo RM | 2007 | Am J Roentgenol2007，189，6： | 1 |
| 20 | Use of disease modifying antirheumatic drugs in patients with psoriatic arthritis显示文摘 | Marguerie L Flipo RM Grardel B | 2002 | Joint Bone Spine2002，69，3： | 1 |
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