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| 1 | Bone–cartilage crosstalk:a conversation for understanding osteoarthritis显示文摘Although cartilage degradation is the characteristic feature of osteoarthritis(OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction(crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage,below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are welldescribed progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development. | David M Findlay Julia S Kuliwaba | 2016 | Bone Research2016，4，3： | 27 |
| 2 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 3 | Bacterial production in fresh and saltwater ecosystems : a cross - system overview显示文摘 | Cole J J Findlay S Pace M L | 1988 | Mar Ecol Prog Set1988，43，： | 1 |
| 4 | Experience with computed tomogaphic angiography for the detection of intracranial aneurysms in the setting of acute subarachnoid hemorrhage显示文摘 | Anderson G B Findlay J M Steinke D E | 1997 | Neurosurgery1997，41，3： | 1 |
| 5 | Capecitabine (Xeloda), an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: result of a randomized phase Ⅱstudy显示文摘 | Van Custem E Findlay M Osterwalder B | 2000 | J Clin Oncol2000，18，6： | 1 |
| 6 | A phase Ⅱ study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF)显示文摘 | Findlay M Cunningham D Norman A | 1994 | Ann Oncol1994，5，7： | 1 |
| 7 | Biofilm dispersal in Xanthomonas campestris is controlled by cell-cell signaling and is required for full virulence to plant 显示文摘 | DOW M J CROSSMAN L FINDLAY K | 2003 | Proceedings of the Na-tional Academy of Sciences of the United States of America2003，100，10： | 1 |
| 8 | The variable-rate mortgage and risk in the mortgage market: An option theory perspective: A note显示文摘 | Findlay M C Capozza D R | 1977 | Journal of Money1977，9，2： | 1 |
| 9 | Target recognition by calmodulin : Dissecting the kinetics and affinity of interaction using short peptide sequences 显示文摘 | P M Bayley W A Findlay S R Martin | 1996 | Protein Science1996，5，： | 1 |
| 10 | Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomizedphase Ⅱ study显示文摘 | Van Cutsem E Findlay M Osterwalder B | 2000 | J Clin Oncol2000，18，6： | 1 |
| 11 | Current concepts of pathophysioloay and management of cerebral vasospasm fol- lowing aneurismal subarachnoid hemorrgage显示文摘 | Findlay J M Macdonald R L Weir B K A | 1991 | Cerebrovase Brain Metab Res1991，3，： | 1 |
| 12 | Use of tamoxifen in hepatocellular carcinoma: a review and paradigm shift显示文摘 | TAN C K CHOW P K FINDLAY M | 2000 | J Gastroenterol Hepatol2000，15，7： | 1 |
| 13 | Osteoclastic metabolism of 25 (OH)-vitamin D3:a potential mechanism for optimization of bone resorption显示文摘 | Kogawa M Findlay DM Anderson PH | 2010 | Endocrinology2010，151，10： | 1 |
| 14 | Biofilm dispersal in Xanthomonas eampestris is controlled by cell-cell signaling and is required for full virulence to plants 显示文摘 | DOW J M CROSSMAN L FINDLAY K | | Proc Natl Aead Sci USA0，100，10： | 1 |
| 15 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 16 | The transfer of transthyretin and receptor-binding properties from the plasma retinol -binding protein to the epididymal retinoic acid- binding protein 显示文摘 | Sundaram M Van Aahen DM Findlay JB | 2002 | Bioehem J2002，362，： | 1 |
| 17 | Capecitabine(Xeloda ) improves medical resource use compared with 5--fluorouracil plus leucovorin in a phase Ⅲ trail conducted in patients with advanced colorectal carcinoma显示文摘 | Twelves C Boyer M Findlay M | 2001 | EurJ Cancer2001，37，15： | 1 |
| 18 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 19 | Aluminum activates an anion channel in the apical cells of wheat roots 显示文摘 | Ryan P R Skerrett M Findlay G P | 1997 | Proceedings of the National Academy of Sciences(USA)1997，94，： | 1 |
| 20 | Dephosphorylation of the nuclear factor of activated T ceils (NFAT) transcription factor is regulated by an RNA-protein scaffold complex 显示文摘 | Sharma S Findlay G M Bandukwala H S | 2011 | Proc Natl Aead Sci U S A2011，108，11： | 1 |
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