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| 1 | Increased dietary intake of tyrosine upregulates melanin deposition in the hair of adult black-coated dogs显示文摘The principle determinant of melanin derived hair colour and patterning in mammals is genetic, but environmental factors are now thought to play a role. It has been shown that the concentration of melanins in cat hair is influenced by the amino acid composition of their diets. Also, puppies were found to require tyrosine(Tyr) intake significantly greater than that recommended for normal growth and development in order to optimize melanin expression in their coats. Much of the work to date has been conducted in growing animals. Less is known about the relationship between nutrition and hair melanin deposition in healthy adult animals. In this study, we fed 2 groups of adult black Labrador retrievers(12 dogs/group) different concentrations of Phe + Tyr(5.6 vs. 3.5 g/Mcal) for 24 weeks and used spectrophotometric measurements every 8 weeks to detect any associated changes in the dogs' hair colour.The higher intake dogs showed reduced dilution of their black coat pigment compared with the lower intake dogs. Specifically, following 16 weeks at the higher intake, the dogs showed less yellow pigmentation to their coats(P = 0.0032), and after 24 weeks at the higher intake, the dogs showed less red(P < 0.0001) and yellow(P< 0.0001), as well as greater overall dark pigmentation(P < 0.0001). In conclusion, we have demonstrated for the first time that colour expression in the hair-coat of adult dogs is dependent on dietary intake of Tyr, and that the requirement appears to be in excess of the minimum level recommended to maintain health. | Adrian Watson Jamie Wayman Russell Kelley AlexANDre Feugier Vincent Biourge | 2018 | Animal Nutrition2018，，4： | 7 |
| 2 | Incidence and risk fac- tors for eentral nervous system occurrence in elderly pa- tients with diffuse large-B-cell lymphoma: influence of ri- tuximab 显示文摘 | Feugier P Virion JM Tilly H | 2004 | Ann Oncol2004，15，： | 1 |
| 3 | Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French patients显示文摘 | Bronowicki JP Bineau C Feugier P | 2003 | Hcpatology2003，37，4： | 1 |
| 4 | Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French patients 显示文摘 | Bronowicki JP Bineau C Feugier P | 2003 | Hepatology2003，37，4： | 1 |
| 5 | Long-term results of theR-CHOP study in the treatment of elderly patients with diffuselarge B-cell lymphoma : a study by the Groupe d’Etude des Lym-phomes de I’ adulte显示文摘 | Feugier P Van Hoof A Sebban C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 6 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma显示文摘 | Feugier P Vanboof A Sebban C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 7 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma:A study by the groupe d'etude des lymphomes de l'adulte显示文摘 | Feugier P Van Hoof A Sebban C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 8 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes del~dulte 显示文摘 | Feugier Pj Van Hoof A Sebban Cj | 2005 | J Clin Oncol2005，23，18： | 1 |
| 9 | Long-term results of the R- CHOP study in the treatment of elderly patients with diffuse large B- cell lymphoma: a study by the Groupe d' Etude des Lymphomes de 1' Adulte 显示文摘 | Feugier P Van Hoof A Sebban C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 10 | Human mesenchymal stem cells improve ex vivo expansion of adult human CD34+ peripheral blood progenitor cells and decrease their allostimulatory capacity显示文摘 | Li N Feugier P Serrurrier B | 2007 | Exp Hematol2007，35，3： | 1 |
| 11 | Long-term results of the RCHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Group d'Etude des Lymphomes del'Adult显示文摘 | Feugier P Van HA Sebban C | 2005 | J Clin Oncol2005，23，： | 1 |
| 12 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d' Etude des Lymphomes de l'Adulte显示文摘 | FEUGIER P VAN HOOF A SEBBAN C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 13 | Long - term results of the R - CHOP study in the treatment of eldly patients with diffuse large B - cell lymphoma: a study by the Grouped' Etude des Lymphomas de I' Adulte 显示文摘 | Feugier P Van Hoofa Sebban C | 2005 | J Clin Oncol2005，23，18： | 1 |
| 14 | Long-Term Results of the R-CHOP Study in the Treatment of Elderly Patients With Diffuse Large B-Cell Lymphoma : A Study by the Groupe d'Etude des Lymphomes de 1'Adulte 显示文摘 | Feugier P Van Hoof A Sebban C | 2005 | J Clin Oneol2005，23，： | 1 |
| 15 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Aduhe显示文摘 | Feugier P Van Hoof A Sebban C | 2005 | J Clin Oncol2005，23，： | 1 |
| 16 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma:a study by the Groupe d'Etude des Lymphomes de l'Adulte显示文摘 | Feugier P van Hoof A Coiffier B | | 0，，18： | 1 |
| 17 | Long-term resultsof the R-CHOP study in the treatment of elderly patientswith difuse large B cell lymphoma : a study by the Groupedf Etude des Lymphomes de V Adulte显示文摘 | Feugier P van Hoof A Sebban V | 2005 | J Clin Oncol2005，23，18： | 1 |
| 18 | Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma:a study by the Group d`Etude des Lymphoma de I`Adulte显示文摘 | Feugier P Hoof AV Sebban C | 2005 | J Clin Oncol2005，23，： | 1 |
| 19 | Primary lymphoma of the liver: clinical-pathological features and relationship with HCV infection in French patients显示文摘 | Bronowicki JP Bineau C Feugier P | 2003 | Hepatology2003，37，4： | 1 |
| 20 | Primary lymphoma of the liver : clinical-pathologicalfeatures and relationship with HCV infection inFrench patients显示文摘 | BRONOWICKI J P BINEAU C FEUGIER P | 2003 | Hepatology2003，37，： | 1 |
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