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| 1 | Incidence of gallstone disease in Italy:Results from a multicenter,population-based Italian study (the MICOL project)显示文摘AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identifi ed as risk factors in men while, in females, the only risk factors were increasing age and a high BMI.Increasing age and pain in the right hypocondrium in men and increasing age in females were identifi ed as predictors of gallstones. Pain in the epigastrium/ right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION:Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confi rmed as the only symptom related to gallstones. | Davide Festi Ada Dormi Simona Capodicasa Tommaso Staniscia Adolfo F Attili Paola Loria Paolo Pazzi Giuseppe Mazzella Claudia Sama Enrico Roda Antonio Colecchia | 2008 | World Journal of Gastroenterology2008，14，34： | 23 |
| 2 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 3 | Acquired gallstone opacification during cholelitholytic treatment with chenodeoxyholic,ursodeoxycholic,and tauroursodeoxycholic acids显示文摘 | Bazzoli F Festi D Mazzella G | 1995 | The American journal of gastroenterology1995，90，6： | 1 |
| 4 | A new splicing acceptor site and poly(A) + sequence signal within DQAI * 0401 and DQA1 * 0501 mRNA 3' UTR contribute to increase the extraordinary diversity of mRNA isoforms 显示文摘 | Hoarau J J Festy F Cesari M | 2005 | Immumogenetics2005，57，34： | 1 |
| 5 | Natural history of gallstone disease:Expectant management or active treatment?Results from a populatonbased cohorl study显示文摘 | Festi D Reggiani M L Attili A F | 2010 | J Gastroenterol Hepatol2010，2，54： | 1 |
| 6 | Identification of endocannabinoids and related compounds in human fat cells 显示文摘 | Gonthier MP Hoareau L Festy F | 2007 | Obesity ( Silver Spring)2007，15，： | 1 |
| 7 | Clinical ef- ficacy and effectiveness of ursodeoxycholic acid in chol- estatic liver diseases显示文摘 | Festi D Montagnani MA zzaroli F | 2007 | Curr Clin Pharmacol2007，2，2： | 1 |
| 8 | Exposure of city residents to carbon monoxide and monocyclic aromatic hydrocarbons during commuting trips in the Paris metro-politan area 显示文摘 | Dor F Moullec Y L Festy B | 1995 | Journal of Air and Waste Management Association1995，45，： | 1 |
| 9 | Clinical efficacy and effectiveness of ursodeoxycholic acid in cholestatic liv- er diseases 显示文摘 | Festi D Montagnani M Azzaroli F | 2007 | Curr Clin Pharmaol2007，2，2： | 1 |
| 10 | Exposure of City Residents to Carbon Monoxide and Monocyclic Aromatic Hydrocarbons During Commuting Trips in the Paris Metropolitan Area显示文摘 | Dor F Moullec Y Le Festy B | 1995 | Journal of the Air & Waste Management Association1995，45，： | 1 |
| 11 | Clinical ef- ficacy and effectiveness of ursodeoxycholic acid in cholestatic liver diseases 显示文摘 | Festi D Montagnani M Azzaroli F | 2007 | Curr Clin Pharmacol2007，2，2： | 1 |
| 12 | Enamel white spot lesions can remineralise using bio-active glass and polyacrylic acid-modified bio-active glass powders 显示文摘 | Milly H Festy F Watson TF | 2014 | Journal of Dentistry2014，42，2： | 1 |
| 13 | Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes显示文摘 | Festy F Hareau L Bes-Houtmann S | 2005 | Histochem Cell Biol2005，124，2： | 1 |
| 14 | Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk 显示文摘 | Maffei F Moraga JMZ Angelini S Zenesini C’ Musti M Festi D | 2014 | Mutagenesis2014，29，3： | 1 |
| 15 | Vettoric US-guided percutaneous alchohol injection of small hepatic and abodominal tumours显示文摘 | Livraghi T Festi F | 1986 | Radiology1986，161，： | 1 |
| 16 | Natural history of gallstone disease:Expectant management or active treatment?Results from a population-based cohort study显示文摘 | Festi D Reggiani M L Attili A F | 2010 | J Gastroenterol Hepatol2010，25，4： | 1 |
| 17 | Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes显示文摘 | Festy F Hoareau L Bes-Houtmann S | 2005 | Histochem Cell Biol2005，124，2： | 1 |
| 18 | Scanning probe energy loss spectroscopy below 50 nm resolution 显示文摘 | Festy F Palmer R E | 2004 | Appl Phys Lett2004，85，： | 1 |
| 19 | Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes显示文摘 | Festy F Hoareau L Bes-Houtmann S | 2005 | Histochem Cell Biol2005，124，2： | 1 |
| 20 | Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes 显示文摘 | Festy F Hoareau L Bes-Houtmann S | 2005 | Histochem Cell Biol2005，124，2： | 1 |
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