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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 3 | Equilibrium Analysis of Current Profiles and in Tokamaks 显示文摘 | Lao L L Ferron J R Groebner R J | 1990 | Nucl Fusion1990，30，6： | 1 |
| 4 | Pharmacokinetics and Safety of Tanaproget,a Nonsteroidal Progesterone Receptor Agonist,in Healthy Women显示文摘 | Bapst J L Ermer J C Ferron G M | | 0，，： | 1 |
| 5 | Safety, Feasibility, and Short-Term Outcomes of Single Port Access Colorectal Surgery: A Single Institutional Case-Matched Study显示文摘 | Sébastien Gaujoux Léon Maggiori Frédéric Bretagnol Marianne Ferron Yves Panis | 2012 | Journal of Gastrointestinal Surgery2012，，3： | 1 |
| 6 | Gamma- linolenic acid from fourteen Boraginaceae species 显示文摘 | GUIL- GUERRERO J L GARCFA - MAROTO F VILCHES- FERRON M A | 2003 | Ind Crop Prod2003，18，1： | 1 |
| 7 | Functional and molecular charaterization of T-type Ca^2+ channel during fetal and postnatal rat heart development 显示文摘 | Ferron L Lapuano V Deroubavix E | 2002 | J Mol Cell Cardiol2002，34，5： | 1 |
| 8 | Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels显示文摘 | Ferron L Capuano V Ruchon Y | 2003 | Circ Res2003，93，12： | 1 |
| 9 | Gene expression non-additivity in immature ears of a heterotic F1 maize hybrid显示文摘 | Pea G Ferron S Gianfranceschi L | 2008 | Plant Science2008，174，： | 1 |
| 10 | Angiotensin II Signaling Pathways Mediate Expression of Cardiac T-Type Calcium Channels 显示文摘 | Ferron L Capuano V Ruchon Y | 2003 | Circ Res2003，93，12： | 1 |
| 11 | Angiotensin Ⅱ signaling pathways mediate expression of cardiac T-type calcium channels显示文摘 | Ferron L Capuano V Ruchon Y | 2003 | Circ Res2003，93，12： | 1 |
| 12 | 显示文摘 | | 1961 | Nature1961，189，： | 1 |
| 13 | Professional risks when carrying out cytoreductive surgery for peritoneal malignancy with hyperthermic intraperitoneal chemotherapy (HIPEC): A French muhicentric survey 显示文摘 | Ferron G Simon L Guyon F | 2015 | Eur J Surg Oncol2015，41，10： | 1 |
| 14 | Cardiac responses to maximal upright cycle exercise in healthy boys and men显示文摘 | Thomas R Popowski B Ferrone L | 1997 | Med Sci sports Exerc1997，29，9： | 1 |
| 15 | Immune escape associatedwith functional defects in antigen-processing machinery in headand neck cancer显示文摘 | Ferris R L Whiteside T L Ferrone S | 2006 | Clin Cancer Res2006，12，13： | 1 |
| 16 | Blocking of iron uptake by monoclonal antibodies specific for the Neisseria meningitidis transferrin-binding protein 2显示文摘 | Pintor M Ferron L Gomez J A | 1996 | J Med Microbiol1996，45，4： | 1 |
| 17 | PerioperativeCAI9-9 levels can predict stage and survival in patientswith resectable pancreatic adenocarcinoma显示文摘 | Ferrone C R Finkelstein D M Thayer S P MuzikanskyA Fernandez-delCastillo C Warshaw A L | 2006 | J ClinOncol2006，24，： | 1 |
| 18 | Current trends in pancreatic cystic neoplasms显示文摘 | FERRONE C R CORREA-GALLEGO C WAR- SHAW A L | 2009 | Arch Surg2009，144，： | 1 |
| 19 | T-type Ca(2) + signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes显示文摘 | Ferron L Ruchon Y Renaud JF | 2011 | Cardiovasc Res2011，90，1： | 1 |
| 20 | Tumor and immune escape显示文摘 | Ferrone S Whiteside T L | 2007 | Surg Oncol Clin N Am2007，16，4： | 1 |
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