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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Effects of thermal and mechanical pretreatments of secondary sludge on biogas production under thermophilic conditions显示文摘 | Mavi Climent Ivet Ferrer Ma del Mar Baeza Adriana Artola Felícitas Vázquez Xavier Font | 2007 | Chemical Engineering Journal2007，，1： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Increasing biogas production by thermal (70℃) sludge we-treatment prior to thermophilic anaerobic digestion显示文摘 | I Ferrer S Pons℃ F Vázquez | 2008 | Biochemical Engineering2008，42，： | 1 |
| 6 | Risk factors of postoperative nosocomial pneumonia after resection of bronchogenic carcinoma 显示文摘 | Diaz- Ravetilat V Ferrer M Gimferrer Garolera JM | 2012 | Respir Med2012，106，10： | 1 |
| 7 | Structural basis for the modulation of CDK-de- pendent/independent activity of cyclin DI显示文摘 | Ferrer J L Dupuy J Bore1 F Jacquamet L Noel J P Dulic V | 2006 | Cell Cy- cle2006，5，： | 1 |
| 8 | Influence of processing variables on mechanical characteristics of sunlight aged polyester-glass fiber composites 显示文摘 | SEGOVIA F FERRER C SALVADOR M D AMIGO V | 2001 | Polymer Degradation and Stability2001，71，： | 1 |
| 9 | Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development显示文摘 | Rodríguez-Concepción M Forés O Martínez-García J.F González V Phillips M.A Ferrer A and Boronat A | | 0，，： | 1 |
| 10 | Patterns in syntactic dependency networks显示文摘 | Ferrer I Cancho R Sole R V Kohler R | 2004 | Physical Review E2004，69，05： | 1 |
| 11 | Capability of microalgae-based wastewater treat- ment systems to remove emerging organic contami- nants A pilot-scale study显示文摘 | MATAMOROS V GUTIERREZ R FERRER I | 2015 | Journal of Hazardous Materials2015，288，2： | 1 |
| 12 | Optimization in complex net- works显示文摘 | Ramon Ferrer i Cancho Ricard V Sol | 2003 | Lecture Notes in Physics2003，625，： | 1 |
| 13 | Risk factors of postoperative nosocomial pneumonia after resection of bronchogenic carcinoma显示文摘 | Díaz-Ravetllat V Ferrer M Gimferrer-Garolera JM | 2012 | Respir Med2012，106，10： | 1 |
| 14 | Biochemical structure features of a novel cyclodextrinase from cow rumen metagenome显示文摘 | Ferrer M Beloqui A Golyshina O V | 2007 | Biotechnology Journal2007，2，： | 1 |
| 15 | Synthesis,characteri-zation,antitumoral and osteogenic activities of quercetin vanadyl(Ⅳ)complexes显示文摘 | FERRER E G SALINAS M V CORREA M J | | 0，，06： | 1 |
| 16 | Exploratory study on the production of coconut sugar in Quezon Province, Philippines (a research note)显示文摘 | Ledesma V T M Ferrer M L M Carandang E V | 1993 | Philippine Journal of Coconut Studies(Philippines)1993，18，1： | 1 |
| 17 | Random amplified polymorphic DNA and amplified fragment length polymorphism assessment of genetic variation in Nicaraguan populations of Pinus oocarpa 显示文摘 | DIAZ V MUHIIZ L M FERRER E | 2001 | Molecular Ecology2001，10，： | 1 |
| 18 | The small-world of human lan- guage 显示文摘 | Ferrer R Cancho I Sol~ R V | 2001 | Proceedings of the Royal Society of London Series B Biological Science2001，268，1482： | 1 |
| 19 | Immunity to murine breast cancer cells modified to express MUC-1,a human breast cancer antigen,in transgenic mice tolerant to human MUC-1显示文摘 | Carr Brendel V Markovic D Ferrer K | 2000 | Cancer Res2000，60，9： | 1 |
| 20 | Increasing biogas production by thermal(70℃) sludge pre-treatment prior to thermophilic anaerobic digestion显示文摘 | Ferrer I Ponsá S Vázquez F | 2008 | Biochemical Engineering Journal2008，42，2： | 1 |
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