|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Combined treatment with a β-blocker and intermittent PTH improves bone mass and mieroarehitecture in ovariectomized mice 显示文摘 | Pierroz D D Bouxsein M L Rizzoli R Ferrari S L | 2006 | Bone2006，39，： | 1 |
| 4 | The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction-baseline characteristics of the study population 显示文摘 | Beautiful SG Ferrari R Ford I | 2008 | Cardiology2008，110，4： | 1 |
| 5 | Surgical treatment of ovarian dermoid cysts: a comparison between laparoscopic and vaginal removal显示文摘 | Ferrari MM Mezzopane R Bulfoni A | 2003 | Eur J Obstet Gynecol Reprod Biol2003，109，1： | 1 |
| 6 | In vivo fractional Pi absorption and NaPi-II mRNA expression in rainbow trout are upregulated by dietary P restriction 显示文摘 | SUGIURA S H McDANIEL N K FERRARIS R P | 2003 | Am J Physiol Regul Integr Comp Physiol2003，285，： | 1 |
| 7 | Surgical treatment of ovarian dermoid cysts : a comparison between laparoscopic and vaginal removal 显示文摘 | Ferrari MM Mezzopane R Bulfoni A | 2003 | Eur J Obstet Gynecol Reprod Biol2003，109，： | 1 |
| 8 | Intestinal transport during fasting and malnutrition 显示文摘 | FERRARIS R P CAREY H V | 2000 | Annu Rev Nutr2000，20，： | 1 |
| 9 | Cardiac remodeling concepts and clinical implications:a consensus paper from an international forum on cardiac remodeling显示文摘 | Cohn JN Ferrari R Sharpe N | 2000 | J Am Coll Cardiol2000，35，3： | 1 |
| 10 | WNT and betacatenin signalling:diseases and therapies显示文摘 | Moon R T Kohn A D De Ferrari G V | 2004 | Nature Reviews Genetics2004，5，9： | 1 |
| 11 | Numerical simulation of flow interference be-tween two circular cylinders in tandem and side-by-side arrangements显示文摘 | Meneghini J R Saltara F Siqueira C L R Ferrari J A | 2001 | Journal of Fluids and Struc-tures2001，15，2： | 1 |
| 12 | Hyper immunoglobulin M sydrome due to CD40 deficiency: clinical, molecular, and immunological features 显示文摘 | Lougaris V Badolato R Ferrari S | 2005 | Immunol Rev2005，203，： | 1 |
| 13 | Metabolic modulation and opti- mization of energy consumption in heart failure 显示文摘 | Ferrari R Cicchitelli G Merli E | 2003 | Med Clin North Am2003，87，2： | 1 |
| 14 | Surface roughness analysis of fiber post conditioning processes 显示文摘 | Mazzitelli C Ferrari M Toledano M Osorio E Monticelli F Osorio R | 2008 | J Dent Res2008，87，2： | 1 |
| 15 | Therapeutic effects of L-carni- tine and propionyl-L-carnitine on cardiovascular diseases: a review 显示文摘 | Ferrari R Merli E Cicchitelli G | 2004 | Ann N Y Acad Sci2004，1033，： | 1 |
| 16 | Cardiac remodeling-concepts and clinical implications:consensus paper from an international forum on cardiac remodleling显示文摘 | Cohn J N Ferrari R Sharpe N | 2000 | JAm CollCardiol2000，35，3： | 1 |
| 17 | Therapeutic effects ofL-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review显示文摘 | Ferrari R Merli E Cicchitelli G | 2004 | Ann N Y Aead Sci2004，1033，： | 1 |
| 18 | Minor constituents of vegetable oils during industrial processing 显示文摘 | FERRARI R A SCHULTE E ESTEVES W | 1996 | J Am Oil Chem Soc1996，73，5： | 1 |
| 19 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Muratori P Muratori L Ferrari R | 2003 | Am J Gasteroenterol2003，，2： | 1 |
| 20 | Contibutions of different Na/Pi cotransporter isoforms to dietary regulation of P transport in the pyloric caeca and intestine of rainbow trout 显示文摘 | SUGIURA S H FERRARIS R P | 2004 | J Exp Biol2004，207，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员