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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 3 | Can- diduria in hospital patients: a study prospective 显示文摘 | KOBAYASHI C C DE FERNANDES O F MIRANDA K C | 2004 | Mycopathologia2004，158，1： | 1 |
| 4 | Patterns of hydrogen in biogas from the anaerobic-digestion of milk-sugars显示文摘 | Mosey F E Fernandes X A | 1989 | Water Science and Technology1989，21，： | 1 |
| 5 | Optimization of the production of biodiesel from soybean oil by ultrasound assisted methanolysis显示文摘 | SANTOS F F P RODRIGUES S FERNANDES F A N | | 0，，： | 1 |
| 6 | Environmental friendly management of CRT glass by foaming with waste egg shells, calcite or dolomite 显示文摘 | Fernandes H R Ferreira D D Andreola F | 2014 | Ceramics International2014，40，13： | 1 |
| 7 | Violence in the emergency department: a survey of health care workers显示文摘 | Fernandes C M Bouthillette F Raboud J M | 1999 | CMAJ1999，161，10： | 1 |
| 8 | A unified periodical boundary conditions for representative volume elements of composites and applications 显示文摘 | Xia Z H Zhang Y F Fernand E | 2003 | International Journal of Solid & Structure2003，40，8： | 1 |
| 9 | Dehydration of melons in a ternary system followed by air-drying显示文摘 | Rodrigues S Fernandes F A N | 2007 | Journal of food engineering2007，80，2： | 1 |
| 10 | 3D reconstitution of porous media from image processing data using a mulfiscale percolation system 显示文摘 | DAIAN J F FERNANDES C P PHILIPPI P C BELLINI DA CUNHA NETO J A | 2004 | Journal of Petroleum Science and Engineering2004，42，1： | 1 |
| 11 | Non-enzymatic browning in clarified cashew apple juice during thermal treatment:kinetics and process control显示文摘 | DAMASCENO L F FERNANDES FAN MAGALHAES M | 2008 | Food Chemistry2008，106，1： | 1 |
| 12 | Room temperature PL characterization of micro and nanocrystalline diamond grown by MPCVD from Ar/H2/CH4 mixtures 显示文摘 | NET() M A FERNANDES A J S SILVA R F | 2007 | Vacuum2007，81，： | 1 |
| 13 | Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels 显示文摘 | Cristovao F Lima Manuel Fernandes - Ferreira Cristina Pereira-Wilson | 2006 | Life Sciences2006，79，21： | 1 |
| 14 | Effects of plough pan development on surface hydrology and on soil physical properties in Southeastern Brazilian pla- teau显示文摘 | Bertolino Aria V F A Fernandes N F Miranda J P L | 2010 | J Hydro2010，393，12： | 1 |
| 15 | Evaluation of the thoracolumbar injury classification system in thoracic and lumbar spinal trauma显示文摘 | JOAQUIM A F FERNANDES Y B CAVALCANTE RA | 2011 | Spine(Phila Pa 1976)2011，36，1： | 1 |
| 16 | Outcome of diaphyseal forearm fracture-nonunions treated by autologous bone grafting and compression plating显示文摘 | Dos Reis FB Faloppa F Fernandes HJ | 2009 | Ann Surg Innov Res2009，3，： | 1 |
| 17 | MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes显示文摘 | Fernandes A Falcao A S Silva R F | 2007 | Neurosci2007，25，4： | 1 |
| 18 | In vtvo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression 显示文摘 | Fernandes J Tardif G Martel-Pelletier J Lascau CV Dupuis M Moldovan F | 1999 | Am J Pathol1999，154，4： | 1 |
| 19 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 20 | A new framework for complex wavelet transforms 显示文摘 | FERNANDES F A VAN SPAENDONCK R L C | 2003 | IEEE Trans Signal Processing2003，51，7： | 1 |
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