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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Pesticide testing by enzyme immunoassay at trace levels in environmental and agricultural samples显示文摘 | Ferguson B S Kelsey D E Fan T S | 1993 | Sci Total Environ1993，132，2： | 2 |
| 3 | Effect of soil drying on ammonia volatilization from surface - applied urea显示文摘 | Ferguson R B and Kissel D E | 1986 | Soil Sci Soc Am J1986，50，： | 2 |
| 4 | Axonal damage in acute multiple sclerosis lesions显示文摘 | Ferguson B Matyszak MK Esiri MM | 1997 | Brain1997，120，： | 2 |
| 5 | Extrusion of metal powders显示文摘 | Ferguson B L | 1991 | International Materials Reviews1991，36，2： | 1 |
| 6 | Estimation of hydrogen peroxide in plant extracts using titanium(Ⅳ) 显示文摘 | PATTERSON B MACRAE E FERGUSON I | 1984 | Analytical Bio- chemistry1984，139，2： | 1 |
| 7 | Adult chronic rhino-sinusitis: definitions, diagnosis, epidemiology, and pathophysiology 显示文摘 | Benninger MS Ferguson B J Hadtey JA | 2003 | Otolaryngol Head Neck Surg2003，129，： | 1 |
| 8 | Quinolone antibiotic with potential to photosensitize skin tumorigensis 显示文摘 | JOHNSON B E GIBBS N K FERGUSON J | 1997 | J Photochem Photobiol B: Biology1997，37，3： | 1 |
| 9 | The chaining approach for software test data generation显示文摘 | Ferguson R Korel B | 1996 | ACM Transactions on Software Engineering and Methodology1996，5，1： | 1 |
| 10 | Empirical Evaluation of Preservation Methods for Faecal DNA 显示文摘 | FRANTZEN M A J SILK J B FERGUSON J W H | 1998 | Molecular Ecology1998，7，： | 1 |
| 11 | Estimation of hydrogen peroxide in plant extracts using titanium (IV) 显示文摘 | Patterson B D Macrea E A Ferguson I B | 1984 | Analytical Bio- chemistry1984，139，： | 1 |
| 12 | Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study 显示文摘 | Wikby A Johansson B Ferguson F | 1994 | Exp Gerontol1994，29，5： | 1 |
| 13 | 查看详情显示文摘 | Keller U Miller D A B Boyd G D Chiu T H Ferguson J F Asom M T | | 0，，： | 1 |
| 14 | Calcium and the regulation of plant growth and senescence显示文摘 | Ferguson I B | 1998 | Hort Sci1998，32，2： | 1 |
| 15 | Effective ab initio emulsion polymerization under RAFT control 显示文摘 | Ferguson C J Hughes R J Pham B T T | 2002 | Macromolecules2002，35，： | 1 |
| 16 | Materials for terahertz science and technology显示文摘 | Ferguson B Zhang X C | 2002 | Nature materials2002，1，： | 1 |
| 17 | Lithium polyacrylate as a binder for tin-cobalt-carbon negative electrodes in lithium-ion batteries显示文摘 | Li J Le D B Ferguson P P | | 0，，08： | 1 |
| 18 | Materials for terahertz science and technology 显示文摘 | Ferguson B Zhang Xicheng | 2002 | Nature Materials2002，1，： | 1 |
| 19 | The Effect of Competition on Recovery Strategies显示文摘 | Ferguson M Toktay B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 20 | Materials for terahertz science and technology显示文摘 | Ferguson B Zhang X C | 2002 | Nat Mater2002，1，1： | 1 |
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