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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Rotational actuators basedon carbon nano- tubes显示文摘 | Fennimore A M | 2007 | Nature2007，424，6947： | 1 |
| 3 | A stable under-gate triode CNT field emitter fabricated via screen printing 显示文摘 | Fennimore A M Cheng L T Roach D H | 2008 | Diamond and Related Materials2008，17，12： | 1 |
| 4 | Genetic basis for seed dormancy 显示文摘 | Foley M E Fennimore S A | 1998 | Seed Sci Res1998，8，： | 1 |
| 5 | Rotational actuators based on carbon nanotubes 显示文摘 | FENNIMORE A M YUZVINSKY T D HAN W Q | 2003 | Nature2003，424，6947： | 1 |
| 6 | A Stable Under-Gate Triode CNT Feld Emitter Fabricated via Screen Printing显示文摘 | Fennimore A M Cheng L T Roach D H | 2008 | Diamond & Related Materials2008，17，： | 1 |
| 7 | Microbial populations and enzyme activities in soils fumigated with methyl bromide alternatives显示文摘 | Stromberger ME Klose S Ajwa H Trout T Fennimore S | 2005 | Soil Science Society of America Journal2005，69，6： | 1 |
| 8 | Rotational actuators based on carbon nanolubes显示文摘 | Fennimore A M Yuzvinsky T D Han W Q | 2003 | Nature2003，424，6947： | 1 |
| 9 | Genetic and physiological evidence for the role of gibberellic acid in the germination of dormant Avena fatua seeds显示文摘 | Fennimore S A Foley M E | | 0，，： | 1 |
| 10 | Dose response of weed seeds and soilborne pathogens to 1,3-D and chloropicrin显示文摘 | Klose S Ajwa HA Fennimore SA | | 0，，26： | 1 |
| 11 | Nurse manager leadership development: leveraging the evidence and system-level support显示文摘 | Fennimore L Wolf G | 2011 | J Nurs Adm2011，41，5： | 1 |
| 12 | Rotational Actuators Based on Carbon Nanotubes显示文摘 | Fennimore A M Yuzvinsky T D Han W Q | 2003 | Nature2003，424，： | 1 |
| 13 | Chloropicrin Effect on Weed Seed Viability显示文摘 | HAAR M J FENNIMORE S A AJWA H A | 2003 | Crop Protetion2003，22，： | 1 |
| 14 | Nurse manger leadership de- velopment: leveraging the evidence and system--level sup- port显示文摘 | Laura Fennimore Gail Wolf | 2011 | J Nurs Adm2011，41，5： | 1 |
| 15 | Preci- sion cutting of nanotubes with a low energy electron beam 显示文摘 | Yuzvinsky T D Fennimore A M Mickelson W | 2005 | Appl Phys Lett2005，86，05： | 1 |
| 16 | Rotation- al actuators based on carbon nanotubes显示文摘 | Fennimore A Yuzvinsky T Han W Q | 2003 | Nature2003，424，6947： | 1 |
| 17 | Rotational actuators based on carbon nanotubes显示文摘 | Fennimore A M Yuzvinshy T D Han W Q | 2003 | Nature2003，424，： | 1 |
| 18 | Genetic basis for seed dormancy显示文摘 | Foley M E Fennimore S A | 1998 | Seed Science Research1998，8，2： | 1 |
| 19 | Multispectral Machine Vision Identification of Lettuce and Weed Seedlings for Automated Weed Control 显示文摘 | David C Slaughter D Ken Giles Steven A Fennimore | 2008 | Weed Technology2008，22，： | 1 |
| 20 | Evaluation of integrated practices for common purslane (Portulaca oleracea ) management in lettuce (Lactuca sativa)显示文摘 | Haar M J Fennimore S A | 2003 | Weed Technology2003，17，： | 1 |
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