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您的检索式：作者名="Fengrun Wu"
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| 1 | Rhodojaponin Ⅵ indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain显示文摘Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients,but currently available treatments are often ineffective.Novel therapeutic targets for the alleviation of neuropathic pain are urgently needed.Rhodojaponin Ⅵ,a grayanotoxin from Rhododendron molle,showed remarkable antinociceptive efficacy in models of neuropathic pain,but its biotargets and mechanisms are unknown.Given the reversible action of rhodojaponin Ⅵ and the narrow range over which its structure can be modified,we perforwmed thermal proteome profiling of the rat dorsal root ganglion to determine the protein target of rhodojaponin Ⅵ.N-Ethylmaleimide-sensitive fusion(NSF) was confirmed as the key target of rhodojaponin Ⅵ through biological and biophysical experiments.Functional validation showed for the first time that NSF facilitated trafficking of the Cav2.2 channel to induce an increase in Ca2+current intensity,whereas rhodojaponin Ⅵ reversed the effects of NSF.In conclusion,rhodojaponin Ⅵ represents a unique class of analgesic natural products targeting Cav2.2 channels via NSF. | Keliang Chen Tao Wang Yong Li Jun Wu Cheng-Xiao Zhao Sheng Liu Fengrun Sun Yehong Fang Jiahuan Hu Jinping Hu Chong-Jing Zhang Haibo Yu Chao Ma Shi-Shan Yu | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 2 | Evolution of shoals and vegetation of Jiuduansha in the Changjiang River Estuary of China in the last 30 years显示文摘The evolution of the shoals and vegetation plays an important role in maintaining the stability of the river regime and the estuarine ecosystem. However, the interaction between the evolution of shoals and vegetation dynamic has rarely been reported. In this study, we determined the interaction between the shoal and vegetation evolution of Jiuduansha in the Changjiang River Estuary in the last 30 years. We did this through the collection and summarization of the existing data of the regional hydrological processes, wading engineering, and vegetation,and combined it with the analysis of nautical charts and remote sensing images. During the past 30 years, the expansion of the shoals within the 0 m isobath in Jiuduansha was obvious, with an increase of 176.5%, while the expansion of the shoals within the 5 m isobath was relatively slow. The regional hydrological characteristics in the Jiuduansha area changed dramatically, especially the sediment discharges. The area of vegetation in Jiuduansha increased from 9.1 km^2 in 1990 to 65.68 km^2 in 2015, while the variations in the different vegetation types were different. The best combination of environmental factors with a significant correlation on the shoals within the 0 m isobath is the area of Spartina alterniflora and Phragmites australis. The evolution of Jiuduansha shoals was significantly affected by the variations in hydrological characteristics. Meanwhile, on a long-term scale, the expansion of the shoals could promote the regional vegetation expansions due to the suitable elevation and environmental conditions it provides. The interaction between the shoal and vegetation evolution varied in the different vegetation types and different elevations. In the future, long-term monitoring and detailed data are needed to the systematical analysis of the interaction between the hydrological processes and the evolution of the shoal and vegetation. | Fengrun Wu Chunfu Tong Mitch Torkelson Yan Wang | 2020 | Acta Oceanologica Sinica2020，39，8： | 2 |
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