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| 1 | miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates显示文摘发展造血作用上的以前的研究主要集中了于发信号和抄写因素,当对包括 microRNAs 的 epigenetic 规定的欣赏是最近的时。这里,我们证明在 zebrafish 和老鼠, miR-142-3p 明确地在造血的干细胞(HSC ) 被表示。在导致的 zebrafish 的 miR-142a-3p 击倒在 aorta-gonad-mesonephros (AGM ) 的 HSC 的一张减少的人口在胸腺的区域以及 T 房间缺点。机械学地, miR-142a-3p 通过干扰素的压抑调整 HSC 形成和区别规章的因素(irf7 ) 7 调停了发炎发信号。最后,我们证明 miR-142-3p 也在老鼠 AGM 涉及 HSC 的发展,建议它有在脊椎动物的一个高度保存的角色。一起,这些调查结果揭开 miR-142a-3p 由镇压在 HSC 的形成和区别起的枢轴的作用 irf7 发信号。 | XinyanLu #x0002A XiajuanLi #x0002A QiupingHe JiaoGao YaGao BingLiu FengLiu | 2013 | Cell Research2013，，12： | 7 |
| 2 | Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer显示文摘AIM: To study the value of monitoring K-ras point mutation at codon 12 and telomerase activity in exfoliated cells obtained from pancreatic duct brushings during endoscopic retrograde cholangiopancreatography (ERCP) in the diagnosis of pancreatic cancer.METHODS: Exfoliated cells obtained from pancreatic duct brushings during ERCP were examined in 27 patients: 23 with pancreatic cancers, 4 with chronic pancreatitis. K-ras point mutation was detected with the polymerase chain reaction and restriction fragment-length polymorphism(PCR-RFLP). Telomerase activity was detected by PCR and telomeric repeat amplification protocol assay (PCR-TRAP-ELISA).RESULTS: The telomerase activities in 27 patients were measured in 21 exfoliated cell samples obtained from pancreatic duct brushings. D450 value of telomerase activities in pancreatic cancer and chronic pancreatitis were 0.446+0.27 and 0.041+0.0111, respectively. Seventy-seven point eight percent (14/18) of patients with pancreatic cancer and none of the patients with chronic pancreatitis showed telomerase activity in cells collected from pancreatic duct brushings when cutoff value of telomerase activity was set at 2.0. The K-ras gene mutation rate (72.2%) in pancreatic cancer was higher than that in chronic pancreatitis (33.3%) (P<0.05). In considering of both telomerase activities and K-ras point mutation, the total positive rate was 83.3% (15/18), and the specificity was 100%.CONCLUSION: Changes of telomerase activities and K-ras point mutation at codon 12 may be an early event of malignant progression in pancreatic cancer. Detection of telomerase activity and K-ras point mutation at codon 12 may be complementary to each other, and is useful in diagnosis of pancreatic cancer. | Guo-XiongZhou Jie-FeiHuang Zhao-ShenLi Guo-MingXu FengLiu HongZhang | 2004 | World Journal of Gastroenterology2004，10，9： | 6 |
| 3 | Expression of NGF family and their receptors in gastric carcinoma:A cDNA microarray study显示文摘AIM: To investigate the expression of NGF family and their receptors in gastric carcinoma and normal gastric mucosa,and to elucidate their effects on gastric carcinoma.METHODS: RNA of gastric cancer tissues and normal gastric tissues was respectively isolated and mRNA was purified.Probes of both mRNA reverse transcription product cDNAs labled with α-33P dATP were respectively hybridized with Atlas Array membrane where NGF and their family genes were spotted on. Hybridized signal images were scanned on phosphor screen with ImageQuant 5.1 software after hybridization. Normalized values on spots were analyzed with ArrayVersion 5.0 software. Differential expression of NGF family and their receptors mRNA was confirmed between hybridized Atlas Array membranes of gastric cancer tissues and normal gastric mucosa, then their effects on gastric carcinoma were investigated.RESULTS: Hybridization signal images on Atlas Array membrane appeared in a lower level of nonspecific hybridization. Both of NGF family and their receptors Trk family mRNA were expressed in gastric cancer and normal gastric mucosa. But adversely up-regulated expression in other tissues and organs. NGF, BDGF, NT-3, NT-4/5, NT-6and TrkA, B and C were down-regulated simultaneously in gastric carcinoma in comparison with normal gastric mucosa. Degrees of down-regulation in NGF family were greater than those in their receptors Trk family. Downregulation of NT-3 and BDGF was the most significant,and TrkC down-regulation level was the lowest in receptors Trk family.CONCLUSION: Down-regulated expression of NGF family and their receptors Trk family mRNA in gastric cancer is confirmed. NGF family and their receptors Trk family probably play a unique role in gastric cancer cell apoptosis by a novel Ras or Raf signal transduction pathway. Their synchronous effects are closely associated with occurrence and development of gastric carcinoma induced by reduction of signal transduction of programmed cell death. | Jian-JunDu Ke-FengDou Shu-YouPeng Bing-ZhiQian, Hua-ShengXiao FengLiu Wei-ZhongWang Wen-XianGuan Zhi-QingGao Ying-BinLiu, Ze-GuangHan | 2003 | World Journal of Gastroenterology2003，9，7： | 5 |
| 4 | Gene Transcription Profile in Mice Vaccinated with Ultraviolet-attenuated Cercariae of Schistosoma japonicum Reveals Molecules Contributing to Elevated IFN-γ Levels显示文摘AVaccination with ultraviolet-attenuated cercariae of Schistosoma japonicum induced protective immunity against challenge infection in experimental animal models. Our preliminary study on .he transcription levels of IFN-γ and IL-4 in splenic CD4~ T cells revealed that attenuated cercariae elicited predominantly a Thl response in mice at the early stage, whereas normal cercariae stimulated primarily Th2-dependent responses. Further analysis on the gene profile of the skin-draining lymph nodes demonstrated that the levels of IFN-γ were significantly higher in vaccinated mice than those in infected mice at day 4, 7 and 14 post-vaccination or post-infection. However, for IL-12 and IL-4, the potent inducers of Th1 and Th2 responses, respectively, as well as IL-10, there were no differences over the course of the experiment between the infected and vaccinated mice. To explore the underlying factors that may potentially contribute to elevated IFN-y in vaccinated mice, the mRNA profiles of the skin-draining lymph nodes at day 4 postexposure were compared using oligonucleotide microarrays. Within the 847 probe sets with increased signal values, we focused on chemokines, cytokines and relevant receptors, which were validated by semi-quantitative RT-PCR. A comprehensive understanding of the immune mechanisms of attenuated cercariae-induced protection may contribute to developing efficient vaccination strategies against S. japonicum, especially during the early stage of infection. | XiangZHU Zhao-SongZHANG Min-JunJI Hai-WeiWU YongWANG Xiao-PingCAI LeiZHANG Shu-YingHU Lin-LinFU FengLIU ChuanSU Guan-LingWU | 2005 | Acta Biochimica et Biophysica Sinica2005，37，4： | 5 |
| 5 | An efficient method for vibration and stability analysis of rectangular plates axially moving in fluid显示文摘An efficient method is developed to investigate the vibration and stability of moving plates immersed in fluid by applying the Kirchhoff plate theory and finite element method.The fluid is considered as an ideal fluid and is described with Bernoulli’s equation and the linear potential flow theory.Hamilton’s principle is used to acquire the dynamic equations of the immersed moving plate.The mass matrix,stiffness matrix,and gyroscopic inertia matrix are determined by the exact analytical integration.The numerical results show that the fundamental natural frequency of the submersed moving plates gradually decreases to zero with an increase in the axial speed,and consequently,the coupling phenomenon occurs between the first-and second-order modes.It is also found that the natural frequency of the submersed moving plates reduces with an increase in the fluid density or the immersion level.Moreover,the natural frequency will drop obviously if the plate is located near the rigid wall.In addition,the developed method has been verified in comparison with available results for special cases. | Yanqing WANG Han WU Fengliu YANG Quan WANG | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，2： | 3 |
| 6 | Liquid-liquid Extraction System Based on Non-ionic Surfactant-salt-H_2O and Mechanism of Drug Extraction显示文摘Extraction behavior of chlorpromazine hydrochloride (CPZ) and procaine hydro- chloride (PCN) in the system described in the title was studied. Research shows that the extraction efficiency of CPZ can amount to 96% by twice extraction, while that of PCN is 77%. This system produces the distribution coefficients (KD) of 12.3 and 2.6 respectively for CPZ and PCN. Extraction mechanism is deduced according to ultraviolet and molecular fluorescence spectra variation of the drugs in the system studied. | LeiLI FengLIU 等 | 2002 | Chinese Chemical Letters2002，13，4： | 3 |
| 7 | Synthesis of carbon nanofibers@MnO_2 3D structures over copper foil as binder free anodes for lithiumion batteries显示文摘A 3D structured composite of carbon nanofibers@MnO2 on copper foil is reported here as a binder free anode of lithium ion batteries, with high capacity, fast charge/discharge rate and good stability. Carbon nanofiber yarns were synthesized directly over copper foil through a floating catalyst method. The growth of carbon nanofiber yarns was significantly enhanced by mechanical polishing of the copper foils, which can be attributed to the increased surface roughness and surface area of the copper foils. MnO2 was then grown over carbon nanofibers through spontaneous reduction of potassium permanganate by the carbon nanofibers. The obtained composites of carbon nanofibers@MnO2 over copper foil were tested as an anode in lithium ion batteries and they show superior electrochemical performance. The initial reversible capacity of carbon nanofibers@MnO2 reaches up to around 998 mAh g-1 at a rate of 60 mmA g-1 based on the mass of carbon nanofibers and MnO2 . The carbon nanofibers@MnO2 electrodes could deliver a capacity of 630 mAh g-1 at the beginning and maintain a capacity of 440 mmAh g-1 after 105 cycles at a rate of 600 mA g-1 . The high initial capacity can be attributed to the presence of porous carbon nanofiber yarns which have good electrical conductivity and the MnO2 thin film which makes the entire materials electrochemically active. The high cyclic stability of carbon nanofibers@MnO2 can be ascribed to the MnO2 thin film which can accommodate the volume expansion and shrinking during charge and discharge and the good contact of carbon nanofibers with MnO2 and copper foil. | Fengliu Lou Haitao Zhou Fride Vullum-Bruer Trung Dung Tran De Chen | 2013 | Journal of Energy Chemistry2013，22，1： | 2 |
| 8 | Outcome of hepatitis C virus infection in Chinese paid plasma donors: A 12–19‐year cohort study显示文摘 | Hui‐YingRao De‐GuiSun Rui‐FengYang FengLiu JianWang BoFeng NanWu Ji‐LianFang Guang‐JunSong HuiMa FangGuo Jiang‐HuaWang Xiao‐BoLi QianJin HongQin HuiZhuang LaiWei | 2012 | Journal of Gastroenterology and Hepatology2012，，3： | 1 |
| 9 | 显示文摘 | YANGNaiTao(杨乃涛) FENGLiu(冯柳) TANXiaoYao(谭小耀) etal | | WujiHuaxueXuebao0，，： | 1 |
| 10 | Synthesis of Novel Maleimide-terminated Thioetherimide Oligomer and Its Bulk Copolymerizayion with Reactive Solvents Polymer 显示文摘 | FengLiu Zhen Wang Huili Yang | 2006 | Polymer2006，47，3： | 1 |
| 11 | Effect on blood pressure of a continued nursing intervention using chronotherapeutics for adult Chinese hypertensive patients显示文摘 | Xiao‐YingZang Jin‐FengLiu Yan‐FenChai Frances Kam YuetWong YueZhao | 2010 | Journal of Clinical Nursing . 2010 (7‐8)2010，，7： | 1 |
| 12 | Aligned carbon nanostructures based 3D electrodes for energy storage显示文摘Electrochemical energy storage systems with high specific energy and power as well as long cyclic stability attract increasing attention in new energy technologies. The principles for rational design of electrodes are discussed to reduce the activation, concentration, and resistance overpotentials and improve the active material efficiency in order to simultaneously achieve high specific energy and power. Three dimensional(3D)nanocomposites are currently considered as promising electrode materials due to their large surface area,reduced electronic and ionic diffusion distances, and synergistic effects. This paper reviews the most recent progress on the synthesis and application of 3D thin film nanoelectrode arrays based on aligned carbon nanotubes(ACNTs) directly grown on metal foils for energy storages and special attentions are paid on our own representative works. These novel 3D nanoelectrode arrays on metal foil exhibit improved electrochemical performances in terms of specific energy, specific power and cyclic stability due to their unique structures.In this active materials coated ACNTs over conductive substrate structures, each component is tailored to address a different demand. The electrochemical active material is used to store energy, while the ACNTs are employed to provide a large surface area to support the active material and nanocable arrays to facilitate the electron transport. The thin film of active materials can not only reduce ion transport resistance by shortening the diffusion length but also make the film elastic enough to tolerate significant volume changes during charge and discharge cycles. The conductive substrate is used as the current collector and the direct contact of the ACNT arrays with the substrate reduces significantly the contact resistance. The principles obtained from ACNT based electrodes are extended to aligned graphene based electrodes. Similar improvements have been achieved which confirms the reliability of the principles obtained. In addition, we also discuss and view the ongoing trends in development of aligned carbon nanostructures based electrodes for energy storage. | Fengliu Lou De Chen | 2015 | Journal of Energy Chemistry2015，24，5： | 1 |
| 13 | Studies on the viscoelasticity of poly(trimethylene terephthalate)/poly(ethylene–octene)/organomontmorillonite nanocomposites显示文摘 | FengLiu YuZhong ChunyanJiang DongWang Zeng‐KunWang Ming‐TaoRun | 2012 | Polym Compos2012，，6： | 1 |
| 14 | Synthesis of Novel Maleimide-Terminated Thioetherimide Oligomer and Its Bulk Copolymerizayion with Reactive Solvents Polymer显示文摘 | FengLiu Zhen Wang Huili Yang | 2006 | Polymer2006，47，3： | 1 |
| 15 | Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors显示文摘 | Jun‐FengLiu Li‐PingGao Shi‐WangWen Hui‐LaiLu JianZhang JianSun Shao‐WeiZhang Qi‐ZhangWang | 2008 | Journal of Gastroenterology and Hepatology2008，，10： | 1 |
| 16 | Responses of human clasp and sling fibers to neuromimetics显示文摘 | ZI‐QIANGTIAN JUN‐FENGLIU GUI‐YINGWANG BAO‐QINGLI FU‐SHUNWANG QI‐ZHANGWANG FU‐MINCAO YUE‐FENGZHANG | 2004 | Journal of Gastroenterology and Hepatology2004，，4： | 1 |
| 17 | Study on Occupational Hazards and Preventive Measures for the Constructors in Building Qinghai-Tibetan Railway显示文摘To analyze the hazard factors for the constructors through the geographic environment along the Qinghai-Tibetan railway. On the basis of the physical examination data of the constructors, we dynamically investigated the impact of the plateau environment on the constructors’ health. We concluded the adaptation after the plain people entering into the plateau, and the application of the medical security measures and the effectiveness of the Plateau diseases preventing and controlling measures during the construction of the Qinghai-Tibetan railway. The results showed that there existed many occupational hazard factors because of the harsh environment in the Qinghai-Tibetan plateau, and they did a severe harm to the constructors. To take an effective prevention measure could apparently alleviate the occupational hazards, and ensure the safety and health of the constructors. The paper not only provided the valuable experiences for the medical support during the economic construction in the Qinghai-Tibetan plateau areas in the future, but also made a contribution for improving the development of the world plateau medicine. | Sun Yongfu Zeng Fengliu | 2006 | 工程科学(英文版)2006，4，2： | 0 |
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