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| 1 | Backfilling technology and strata behaviors in fully mechanized coal mining working face显示文摘Based on the principle of fully mechanized backfilling and coal mining technology and combined with the Xingtai Coal Mine conditions,we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology.Firstly,we define the practical backfilling process as the ''(from backfilling scraper conveyor's) head to tail backfilling,step by step swinging up of the tamping arm,gradual compacting,moving formed backfilling scraper conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement''.Meanwhile,the stress changes of backfill body in coal mined out area was monitored by stress sensors,and the roof caving law was analyzed by monitoring the dynamic subsidence of à210 west roadway of this face.The site tests results show that using this new backfilling and coal mining integrated technology,the production capacity in the 7606 working face can reach to 283,000 ton a year,and 282,000 ton of solid materials(waste and fly ash) is backfilled,which meets the needs of high production and efficiency.The goaf was compactly backfilled with solid material and the strata behavior was quite desirable,with an actual maximum vertical stress of the backfill body of 5.5 MPa.Backfill body control the movement of overburden within a certain range,and there is no collapses of major areas in the overlying strata upon backfilled gob.The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively,which proved the practical significance of this integrated technology. | Zhang Qiang Zhang Jixiong Huang Yanli Ju Feng | 2012 | International Journal of Mining Science and Technology2012，22，2： | 55 |
| 2 | Visualization of the complex structure and stress field inside rock by means of 3D printing technology显示文摘Accurate characterization and visualization of the complex inner structure and stress distribution of rocks are of vital significance to solve a variety of underground engineering problems. In this paper, we incorporate several advanced technologies, such as CT scan, three-dimensional(3D) reconstruction, and 3D printing, to produce a physical model representing the natural coal rock that inherently contains complex fractures or joints. We employ 3D frozen stress and photoelastic technologies to characterize and visualize the stress distribution within the fractured rock under uniaxial compression. The 3D printed model presents the fracture structures identical to those of the natural prototype. The mechanical properties of the printed model,including uniaxial compression strength, elastic modulus,and Poisson's ratio, are testified to be similar to those of the prototype coal rock. The frozen stress and photoelastic tests show that the location of stress concentration and the stress gradient around the discontinuous fractures are in good agreement with the numerical predictions of the real coalsample. The proposed method appears to be capable of visually quantifying the influences of discontinuous,irregular fractures on the strength, deformation, and stress concentration of coal rock. The method of incorporating3 D printing and frozen stress technologies shows a promising way to quantify and visualize the complex fracture structures and their influences on 3D stress distribution of underground rocks, which can also be used to verify numerical simulations. | Yang Ju Heping Xie Zemin Zheng Jinbo Lu Lingtao Mao Feng Gao Ruidong Peng | 2014 | Chinese Science Bulletin2014，59，36： | 41 |
| 3 | Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases显示文摘背景有针的绳索殴打的脊柱受伤的发生在发达国家高并且现在在中国正在成长。而且,针的绳索损害主要在有长寿期待的年轻人发生。很多病人因此是为他们的生活的其余部分的轮椅界限。因此,针的绳索损害引起了世界范围的大担心。尽管有大努力,从针的绳索损害的恢复仍然保持不能令人满意。基于针的绳索殴打的病理,早 neurosurgical 干预的一个想法在这研究被提出了。有“完全”的针的绳索损害的 30 个病人全部或象美国脊柱受伤协会(亚洲) A 分类的方法 A 被学习。受伤椎骨(e) ,脊椎的列的内部固定,和为硬膜上的解压缩的双边的 laminectomy 的矫形治疗被 neurosurgical 管理直接跟随,包括恢复脑髓的液体流动和针的绳索的清创术的蛛网状的粘附的分离有伴随物 intramedullary 解压缩的坏死的织物。康复在操作以后开始了 17 天。最后的结果在 3 月康复以后被评估。皮尔森 chi 平方分析被用于统计分析。所有病人恢复了的结果走的某能力。最少的恢复病人能在稳定忍受膝关节的重量与 wheeled 重量支持和帮助走(12 个盒子, 40%) 。13 个病人(43%) 能与一双丁字拐走,一根棍子或没有任何支持。在损害以后预定操作是重要的。一扇最佳的操作时间窗户在损害以后在 4-14 天被识别。康复跟随的针的绳索殴打的结论早 neurosurgical 干预能显著地改进病人的运动。它是为针的绳索殴打的一条治疗学的途径的一个新想法并且被证明了很成功。 | ZHU Hui FENG Ya-ping Young Wise YOU Si-wei SHEN Xue-feng LIU Yan-sheng JU Gong | 2008 | Chinese Medical Journal2008，，24： | 30 |
| 4 | An experimental investigation on the mechanism of fluid flow through single rough fracture of rock显示文摘The structure of fractures in nature rock appears irregular and induces complicated seepage flow behavior.The mechanism and quantitative description of fluid flow through rock fractures is a difficult subject that has been greatly concerned in the fields of geotechnical,mining,geological,and petroleum engineering.In order to probe the mechanism of fluid flow and the effects of rough structures,we conducted a few laboratory tests of fluid flow through single rough fractures,in which the Weierstrass-Mandelbrot fractal function and PMMA material were employed to produce the fracture models with various fractal roughnesses.A high-speed video camera was employed to record the fluid flow through the entire single rough fracture with a constant hydraulic pressure.The properties of fluid flow varying with the fracture roughness and the influences of the rough structure were analyzed.The components of flow resistance of a single rough fracture were discussed.A fractal model was proposed to relate the fluid resistance to the fracture roughness.A fractal equivalent permeability coefficient of a single rough fracture was formulated.This study aims to provide an experimental basis and reference for better understanding and quantitatively relating the fluid flow properties to the structures of rock fractures. | JU Yang ZHANG QinGang YANG YongMing XIE HePing GAO Feng WANG HuiJie | 2013 | Science China(Technological Sciences)2013，56，8： | 28 |
| 5 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 6 | Responses and stability of power system under small Gauss type random excitation显示文摘With the integration of renewable power and electric vehicle,the power system stability is of increasing concern because the active power generated by the renewable energy and absorbed by the electric vehicle vary randomly.Based on the deterministic differential equation model,the nonlinear and linear stochastic differential equation models of power system under Gauss type random excitation are proposed in this paper.The angle curves under different random excitations were simulated using Euler-Maruyama(EM) numerical method.The numerical stability of EM method was proved.The mean stability and mean square stability of the power system under Gauss type of random small excitation were verified theoretically and illustrated with simulation sample. | ZHANG JianYong JU Ping YU YiPing WU Feng | 2012 | Science China(Technological Sciences)2012，55，7： | 20 |
| 7 | Research on in-situ condition preserved coring and testing systems显示文摘As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become urgent.Traditional coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured parameters.Herein,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed environment.The ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing film.The ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are realized.CH_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/min.The average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is achieved.The error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact test.The system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes. | He-Ping Xie Tao Liu Ming-Zhong Gao Ling Chen Hong-Wei Zhou Yang Ju Feng Gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan Gao Cong Li Zhi-Qiang He Ming-Qing Yang Zhi-Yu Zhao | 2021 | Petroleum Science2021，18，6： | 19 |
| 8 | Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma显示文摘AIM:To investigate the value of combined detection of circulating cell-free DNA(cfDNA),a-fetal protein(AFP) and a L-fucosidase(AFU) for diagnosis of hepatocellular carcinoma(HCC).METHODS:Serum samples from 39 HCC patients and 45 normal controls were collected.Branched DNA(bDNA) was used to detect the level of cfDNA,and a receiver operating characteristic curve was employed to evaluate the diagnostic sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio,negative likelihood ratio and Youden index,and to assess the diagnostic efficiency and their correlations with the clinicopathological features.AFP and AFU were detected by chemiluminescence and colorimetry,respectively.The significance of combined detection of the three biomarkers was discussed.RESULTS:cfDNA level was increased in 22 of the 39 HCC samples and in 2 of the 45 normal controls.cfDNA level in HCC samples was significantly higher than that in normal controls(P < 0.05).There were significant differences in sex and extra-and intrahepatic metastasis(P < 0.05).There was no significant correlation between cfDNA,AFP and AFU in the detection of HCC.The sensitivity of combined detection of cfDNA with one marker(AFP or AFU) and cfDNA with two markers(AFP and AFU) was 71.8%,87.2% and 89.7% vs 56.4%,53.8% and 66.7% for cfDNA,AFP and AFU used alone,respectively,the difference being statistically significant(P < 0.05).CONCLUSION:Quantitative analysis of cfDNA is sensitive and feasible,and the combined detection of cfDNA with AFP or AFU or both could improve the diagnostic sensitivity for HCC. | Ken Chen Hong Zhang Li-Na Zhang Shao-Qing Ju Jing Qi Dong-Feng Huang Feng Li Qun Wei Jing Zhang | 2013 | World Journal of Gastroenterology2013，19，20： | 16 |
| 9 | Technology and Experiments of 42CrMo Bearing Ring Forming Based on Casting Ring Blank显示文摘Bearing ring is the crucial component of bearing. With regard to such problems as material waste, low efficiency and high energy consumption in current process of producing large bearing ring, a new process named 'casting-rolling compound forming technology' is researched by taking the typical 42CrMo slew bearing as object. Through theoretical analysis, the design criteria of the main casting-rolling forming parameters are put forward at first. Then the constitutive relationship model of as-cast 42CrMo steel and its mathematical model of dynamic recrystallization are obtained according to the results of the hot compression experiment. By a coupled thermal-mechanical finite element model for radial-axial rolling of bearing ring, the fraction of dynamic recrystallization is calculated and recrystallized grains size are predicated. Meanwhile, the effects of the initial rolling temperature and feed rate of idle roll on material microstructure evolution are analyzed. Finally, the industrial rolling experiment is designed and performed, based on the simulation results. In addition, mechanical and metallographic tests are conducted on rolled bearing ring to get the mechanical parameters and metallographic structure. The experimental data and results show that the mechanical properties of bearing ring produced by casting-rolling compound forming technology are up to industrial standard, and a qualified bearing ring can be successfully formed by employing this new technology. Through the study, a process of forming large bearing ring directly by using casting ring blank is obtained, which could provide an effective theoretical guidance for manufacturing large ring parts. It also has an edge in saving material, lowering energy and improving efficiency. | LI Yongtang JU Li QI Huiping ZHANG Feng CHEN Guozhen WANG Mingli | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 16 |
| 10 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 11 | Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage显示文摘Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats (7 days old) subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2′-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2′- deoxyuridine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury. | Zhichun Feng Jing Liu Rong Ju | 2013 | Neural Regeneration Research2013，8，13： | 15 |
| 12 | Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris:A Randomized Clinical Trial显示文摘 | Chao Wu Hong-Zhong Jin Dan Shu Feng Li Chun-Xia He Ju Qiao Xiao-Ling Yu | 2015 | Chinese Medical Journal2015，，4： | 14 |
| 13 | Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration显示文摘嗜中性的渗入是含酒精的 steatohepatitis 的一个特点;然而,内在的机制仍然保持不清楚。我们以前报导 synergistically 喂的 chronic-plus-binge 乙醇导致 neutrophils 的肝的招募,它贡献肝损害。在这份报纸,我们在 chronic-plus-binge 乙醇喂导致调查了不变的自然漂亮 T (iNKT ) 房间的角色肝的嗜中性的渗入和肝损害。野类型并且 iNKT 的二紧张房间缺乏的老鼠(CD1d 缺乏并且 Jα 18-deficient 老鼠) 受到喂的 chronic-plus-binge 乙醇。肝损害和发炎被检验。synergistically 喂的 Chronic-plus-binge 乙醇增加了肝的 iNKT 房间的数字并且导致了他们的激活,与独自的长期的喂或饮酒作乐相比。iNKT 房间缺乏的老鼠被保护免受 chronic-plus-binge 的伤害导致乙醇的肝的嗜中性的渗入和肝损害。而且,显著地喂几基因的肝的表示在野类型的老鼠与发炎和嗜中性的招募联系了的 upregulated 的 chronic-plus-binge 乙醇,而是这些基因的正式就职在 iNKT 被废除房间缺乏的老鼠。重要地,几 cytokines 和 chemokines (例如, MIP-2, MIP-1, IL-4, IL-6 和 osteopontin ) 在嗜中性的渗入包含了在肝的 NKT 房间的 upregulated 从 chronic-plus-binge 被孤立与喂对的老鼠相比的喂乙醇的老鼠。最后,有堵住抗体的 CD1d 的处理,堵住 iNKT 房间激活,部分阻止了 chronic-plus-binge 导致乙醇的肝损害和发炎。喂的 Chronic-plus-binge 乙醇激活肝的 iNKT 房间,它在早含酒精的肝损害的发展起一个关键作用,部分地由释放招募的调停人 neutrophils 到肝,并且这样, iNKT 房间为含酒精的肝的治疗代表一个潜在的治疗学的目标疾病。 | Stephanie Mathews Dechun Feng Igor Maricic Cynthia Ju Vipin Kumar Bin Gao | 2016 | Cellular & Molecular Immunology2016，13，2： | 14 |
| 14 | Study on protecting effects of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis显示文摘AIM: To investigate the protective effects and mechanisms of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis (SAP). METHODS: The SAP rat models were prepared and randomly assigned to the model control group, Baicalin treated group, and Octreotide treated group while other healthy rats were assigned to the sham-operated group. Rat mortality, levels of ALT, AST, liver and pancreas pathological changes in all groups were observed at 3, 6 and 12 h after operation. Tissue microarray (TMA) sections of hepatic tissue were prepared to observe expression levels of Bax, Bcl-2 protein and Caspase-3, and changes of apoptotic indexes.RESULTS: Rat survival at 12 h, expression levels of Bax, Caspase-3 protein and apoptotic indexes of liver were all significantly higher in treated groups than in model control group. While the liver and pancreas pathological scores, contents of ALT, AST, and expression levels of Bcl-2 protein were all lower in treated groups than in the model control group. CONCLUSION: Both Baicalin and Octreotide can protect rats with SAP by decreasing the contents of ALT, AST and expression levels of Bcl-2 protein, and improving the expression levels of Bax protein, Caspase-3 protein, and inducing apoptosis. | Xi-Ping Zhang Guang-Hua Feng Wei Zhu Yang Cai Qi-Jun Yang Tong-Fa Ju Qi xie Wen-Qin Yuan Jie Zhang Zheng Ren | 2008 | World Journal of Gastroenterology2008，14，42： | 13 |
| 15 | Lattice-Boltzmann simulation of microscale CH_4 flow in porous rock subject to force-induced deformation显示文摘Accurate knowledge of the influence of rock deformation on the permeability of fluid flow is of great significance to a variety of engineering applications, such as simultaneous extraction of coal and gas, oil/gas exploitation, CO2 geological sequestration, and underground water conservation. Based on the CT representation of pore structures of sandstones, a LBM(Lattice Boltzmann Method) for simulating CH4 flow in pore spaces at microscale levels and a parallel LBM algorithm for largesize porous models are developed in this paper. The properties of CH4 flow in porous sandstones and the effects of pore structure are investigated using LBM. The simulation is validated by comparing the results with the measured data. In addition, we incorporate LBM and FEM to probe the deformation of microstructures due to applied triaxial forces and its influence on the properties of CH4 flow. It is shown that the proposed method is capable of visually and quantitatively describing the characteristics of microstructure, spatial distribution of flow velocity of CH4,permeability, and the influences of deformation of pore spaces on these quantities as well. It is shown that there is a good consistency between LBM simulation and experimental measurement in terms of the permeability of sandstone with various porosities. | Yang Ju Jinbo Wang Feng Gao Heping Xie | 2014 | Chinese Science Bulletin2014，59，26： | 13 |
| 16 | Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals显示文摘线粒体为精力新陈代谢和反应的氧种类(ROS ) 的生产是必要的。在未经触动的房间,呼吸线粒体展览自发的 “ superoxide flashes”,对短暂 mitochondrial 渗透转变(tMPT ) 结果的 quantal 生产 ROS 事件。这里,我们在表示 superoxide 生物传感器 mt-cpYFP 的生活老鼠在 mitochondrial superoxide 闪光和 tMPT 活动的 vivo 成像执行第一,并且表明他们联合到整个身体的葡萄糖新陈代谢。柔韧的 tMPT/superoxide 闪光活动发生在骨胳的肌肉和 anesthetized 的臀部的神经转基因的老鼠。在骨胳的肌肉,成像 tMPT/superoxide 闪光揭示了线粒体的迷宫的三维的网络同时地操作。tMPT/superoxide 闪光活动响应全身的葡萄糖挑战或胰岛素刺激澎湃,以一种显然调制频率的方式并且也在 tMPT 的 gating 模式包含移动。因此,在 tMPT 依赖的 mitochondrial ROS 的 vivo 成像,信号和 metabolism-tMPT-superoxide 的发现闪光联合标记为 mitochondrial 功能并且 ROS 处于健康和疾病发信号的学习的重要工艺、概念的进展。 | Huaqiang Fang Min Chen Yi Ding Wei Shang Jiejia Xu Xing Zhang Wanrui Zhang Kaitao Li Yao Xiao Feng Gao Shujiang Shang Jing-Chao Li Xiao-Li Tian Shi-Qiang Wang Jingsong Zhou Noah Weisleder Jianjie Ma Kunfu Ouyang Ju Chen Xianhua Wang Ming Zheng Wang Wang Xiuqin Zhang Heping Cheng | 2011 | Cell Research2011，21，9： | 11 |
| 17 | WS2 nanoflakes from nanotubes for electrocatalysis显示文摘为切开的水的下一代的催化剂向可更新的氢经济是关键的。MoS2 和 WS2 在边地点与高催化的活动代表地球丰富的、高贵金属阴极选择。在他们的开发的一挑战是这些材料到 nanostructure 以便通过另外的边地点的创造完成增加的性能。在这个工作,我们表明一条简单线路用 sonochemical 脱落形成 nanostructured-WS2 在 WS2 nanotubes 打破夹层和 intralayer 契约。产生很少层 nanoflakes 是与边地点的高密度宽的 100 nm。WS2 nanoflakes 为氢进化反应作为阴极被利用(她的) 并且展览上级性能到 WS2 nanotubes 和体积粒子与一个更低的发作潜力,更浅的 Tafel 斜坡和增加的当前的密度。未来工作可以采用进一步改进 electrocatalytic 活动的极端小的 nanoflakes,掺杂物原子,或 graphene 混血儿。 | Charina L. Choi Ju Feng Yanguang Li Justin Wu Alia Zak Reshef Tenne Hongjie Dai | 2013 | Nano Research2013，6，12： | 11 |
| 18 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 19 | MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein显示文摘AIM: To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus(HCV) core protein in Hep G2 cells.METHODS: HCV genotype 1b core protein was cloned and expressed in Hep G2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory element binding protein 2(SREBP2) and the rate-limiting enzyme in cholesterol synthesis(HMGCR) was measured by quantitative real-time PCR and immunoblotting after transfection. The effects of core protein on the SREBP2 promoter and 3'-untranslated region were analyzed by luciferase assay. We used different target predictive algorithms, micro RNA(mi RNA) mimics/inhibitors, and site-directed mutation to identify a putative target of a particular mi RNA.RESULTS: HCV core protein expression in Hep G2 cells increased the total intracellular cholesterol level(4.05 ± 0.17 vs 6.47 ± 0.68, P = 0.001), and this increase corresponded to an increase in SREBP2 and HMGCR m RNA levels(P = 0.009 and 0.037, respectively) and protein expression. The molecular mechanism studyrevealed that the HCV core protein increased the expression of SREBP2 by enhancing its promoter activity(P = 0.004). In addition, mi R-185-5p expression was tightly regulated by the HCV core protein(P = 0.041). Moreover, overexpression of mi R-185-5p repressed the SREBP2 m RNA level(P = 0.022) and protein expression. In contrast, inhibition of mi R-185-5p caused upregulation of SREBP2 protein expression. mi R-185-5p was involved in the regulation of SREBP2 expression by HCV core protein. CONCLUSION: HCV core protein disturbs the cholesterol homeostasis in Hep G2 cells via the SREBP2 pathway; mi R-185-5p is involved in the regulation of SREBP2 by the core protein. | Min Li Qi Wang Shun-Ai Liu Jin-Qian Zhang Wei Ju Min Quan Sheng-Hu Feng Jin-Ling Dong Ping Gao Jun Cheng | 2015 | World Journal of Gastroenterology2015，21，15： | 10 |
| 20 | Protective effect of the extract of Yi-Qi-Fu-Mai preparation on hypoxia-induced heart injury in mice显示文摘Yi-Qi-Fu-Mai(YQFM) is extensively used clinically to treat cardiovascular diseases in China. To explore the anti-hypoxia effect of the extract of YQFM preparation(EYQFM), the EYQFM(1.4, 2.8, and 5.5 g·kg-1·d-1) was assessed for its heart-protective effect in a chronic intermittent hypoxia(CIH) animal model(oxygen pressure 7%-8%, 20 min per day) for 28 days of treatment. Betaloc(0.151 6 g·kg^(-1)·d^(-1)) was used as a positive control. The histopathological analyses of heart in CIH mice were conducted. Several cardiac state parameters, such as left ventricular ejection fractions(EF), stroke volume(SV), expression of creatine kinase(CK), lactate dehydrogenase(LDH), superoxide dismutase(SOD), and malondialdehyde(MDA) were measured. The results showed that treatment with EYQFM markedly reversed swelling of the endothelial cells and vacuolization in the heart when compared with the model group. Further study demonstrated that EYQFM significantly improved ventricular myocardial contractility by increasing EF and SV. In addition, EYQFM inhibited the activity of CK, LDH, decreased the level of MDA and improved SOD activity. The results demonstrated that EYQFM significantly improved the tolerability of myocardium to hypoxia and ameliorated the cardiac damage in the CIH model. | FENG Ya-Qian JU Ai-Chun LIU Chun-Hua WANG Ting YU Bo-Yang QI Jin | 2016 | Chinese Journal of Natural Medicines2016，14，6： | 10 |
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