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| 1 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 2 | Factors affecting phosphate adsorption equilibria in lake sediments显示文摘 | Ku W C Digiano F A Feng T H | 1978 | Water Res1978，12，： | 2 |
| 3 | Impedance specifications for stable DC distributed power systems 显示文摘 | FENG X LIU J LEE F C | 2002 | IEEE Transactions on Power Electronics2002，17，2： | 1 |
| 4 | Narcissus analysis for cooled staring IR system 显示文摘 | He F Y Cui J C Feng S L | 2007 | SPIE2007，6772，67： | 1 |
| 5 | The structural and magnetic properties of Mn2 xFexNiGa Heusler alloys显示文摘 | LUO H Z MENG F B FENG Z Q LI Y X ZHU W WU G H ZHU X X JIANG C B XU H B | 2010 | J Appl Phys2010，107，01： | 1 |
| 6 | 查看详情显示文摘 | Liao Y Wang Y Q Feng X X Wang W C Xu F J Zhang L Q | | 0，，： | 1 |
| 7 | A note on computational formulas for the Drazin inverse of certain block matrices 显示文摘 | Bu C J Feng C C Dong P F | 2012 | Appl Math Comput2012，38，1： | 1 |
| 8 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | Soft sets combined with fuzzy sets and rough sets:a tentative approach显示文摘 | Feng F Li C X Davvaz B | 2010 | Soft Com- puting2010，14，9： | 1 |
| 10 | A dual-chamber microbial fuel cell with conductive film-modified anode and cathode and its application for the neutral electro-Fenton process显示文摘 | Feng C H Li F B Liu H Y | 2010 | Electrochimica Acta2010，55，： | 1 |
| 11 | A polypyrrole/anthraquinone2,6-disulphonic disodium salt (PPy/AQDS)-modified anode to improve performance of microbial fuel cells显示文摘 | FENG C H MA L LI F B | 2010 | Biosensors and Bioelectronics2010，25，： | 1 |
| 12 | STS markers linked tO the R fl fertility restorer gene of cotton显示文摘 | Feng C D Stewart J M Zhang J F | 2005 | Theor Appl Genet2005，110，23： | 1 |
| 13 | SMB: collision detection based on temporal coherence 显示文摘 | LI C F FENG Y T OWEN D R J | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，1922： | 1 |
| 14 | Synthesis and characterization of PVC/Montmorillonite nanocomposite显示文摘 | F L GONG C G ZHAO M FENG | 2004 | Materials Science2004，，39： | 1 |
| 15 | Antibact erial funct ionalizat ion of an exper-im ent alself- et ching primer by inorganic agent s Micro -biological andbiocompat ibilit y evaluat ions 显示文摘 | Ming F Feng C | 2007 | Bion ocEng2007，24，5： | 1 |
| 16 | A novel design and micro- fabrication for copper (Cu) electroforming bipolar plates 显示文摘 | HSIEH S S HUANG C F FENG C L | 2008 | Micron2008，39，： | 1 |
| 17 | 查看详情显示文摘 | Dong Q F Manns D C Feng G P | | 0，，： | 1 |
| 18 | SUMO-1/Ubc9 promotes nuclear accu- mulation and metabolic stability of tumor suppressor Smad4 显示文摘 | Lin Xia Liang Min Liang Yao-yun Brunicardi F C Feng Xin-hua | 2003 | J Biol Chem2003，278，31： | 1 |
| 19 | Surface Roughness Predic tive Modeling: Neural Networks Versus Regres sion显示文摘 | Feng C X Wang X F | 2003 | IIE Transactions2003，35，1： | 1 |
| 20 | The synchronization of Rossler hyperchaotic system with a fractional order 显示文摘 | Xu C Feng J W Austin F | 2009 | International Journal of Nonlinear Sciences and Numerical Simulation2009，10，1112： | 1 |
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