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| 1 | Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis显示文摘AIM: To study the inhibitory effect of Huqi San (Qi-protecting powder) on rat prehepatocarcinoma induced by diethylinitrosamine (DEN) by analyzing the mutational activation of c-fos proto-oncogene and over-expression of c-jun and c-myc oncogenes. METHODS: A Solt-Farber two-step test model of prehepatocarcinoma was induced in rats by DEN and 2-acetylamino? uorene (AAF) to investigate the modifying effects of Huqi San on the expression of c-jun, c-fos and c-myc in DEN-mediated hepatocarcinogenesis. Huqi San was made of eight medicinal herbs containing glycoprival granules, in which each milliliter contains 0.38 g crude drugs. γ-glutamy-transpeptidase-isoenzyme (γ-GTase) was determined with histochemical methods. Level of 8-hydroxydeoxyguanosine (OHdG) formed in liver and c-jun, c-fos and c-myc proto-oncogenes were detected by immunohistochemical methods. RESULTS: The level of 8-OHdG, a mark of oxidative DNA damage, was signifi cantly decreased in the liver of rats with prehepatocarcinoma induced by DEN who received 8 g/kg body weight or 4 g/kg body weight Huqi San before (1 wk) and after DEN exposure (4 wk). Huqi San-treated rats showed a signifi cant decrease in number of γ-GT positive foci (P < 0.001, prevention group: 4.96 ± 0.72 vs 29.46 ± 2.17; large dose therapeutic group: 7.53 ± 0.88 vs 29.46 ± 2.17). On the other hand, signifi cant changes in expression of c-jun, c-fos and c-myc were found in Huqi San-treated rats. CONCLUSION: Activation of c-jun, c-fos and c-myc plays a crucial role in the pathogenesis of liver cancer.Huqi San can inhibit the over-expression of c-jun, c-fos and c-myc oncogenes and liver preneolastic lesions induced by DEN. | XiaLi,Ping Feng Zhao-Yang Wen Xue-Jiang Wang Zheng-Ming Shi SuppoSed by | 2007 | World Journal of Gastroenterology2007，13，31： | 10 |
| 2 | Interactions of pyrogallol red with proteins and the determination of proteins by resonance light-scattering | Hu Xiaoli, female, 35 years old, instructor. * Supported by the National Natural Science Foundation of China (NSFC) and the Municipal Science Foundation of Chongqing for Young and Middle Scientists (No: 97-4729). Hu Xiaoli, Feng Ping, Li Yua | 1998 | 西南师范大学学报(自然科学版)1998，23，5： | 3 |
| 3 | Neuropilins are positive regulators ofHedgehog signal transduction显示文摘 | Hillman RT Feng BY Ni J | 2011 | Genes Dev2011，25，22： | 1 |
| 4 | Current research in perineu- ral invasion of cholangioeareinoma显示文摘 | Shen FZ Zhang BY Feng YJ | 2010 | J Exp Clin Cancer Res2010，29，10： | 1 |
| 5 | Development of a new pre-derivatization LC method for analysis of branched-chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a result of acute hepatic injury 显示文摘 | Cheng JY Feng F Zhuang BY | 2009 | Chromatographia2009，70，7： | 1 |
| 6 | Determination of residual stresses in thick-section weldments 显示文摘 | Shim By Y Feng Z Lee S | 1992 | Welding Research1992，，9： | 1 |
| 7 | Computational prediction of miRNA signature related to valvular heart disease with atrial fibrillation us- ing coherent data sources at different molecular lvels 显示文摘 | Feng W Rao N Li BY | 2014 | Cardio- vascular Research2014，103，1： | 1 |
| 8 | Dynamic Simulation and Stress Analysis for Reciprocating Compressor Crankshafl显示文摘 | Yu BY Feng QK Yu XL | 2013 | Proceedings of the Institution of Mechanical Engineers Part C:Journal of Mechanical Engineering Science2013，227，4： | 1 |
| 9 | Diagnosis and therapeutic hysteroscopy for traumatic intrauterine adhesions after induced abortions: clinical analysis of 365 cases显示文摘 | Feng ZC Yang BY Shao JY | 1999 | Gynaecol Endosc1999，8，2： | 1 |
| 10 | Myocardial protection related to magnesium content of cold blood hyperkalemic cardioplegic solutions in CABG 显示文摘 | Ji BY Feng ZY Liu JP | 2002 | Extra Corpor Technol2002，34，2： | 1 |
| 11 | Inflammation status of rab-bit carotid artery moriel endothelium during intermittent hypoxiaexposure and its relationship with leptin显示文摘 | FENG J CHEN BY CUI LY et aJ | 2009 | Sleep Breath2009，13，3： | 1 |
| 12 | Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats 显示文摘 | Wang H Feng F Zhuang BY Sun Y | 2009 | Journal of Ethnopharmacology2009，126，2： | 1 |
| 13 | Organochlorine pesticide (DDT and HCH) residues in the Taihu Lake Region and its movement in soil-water system Ⅰ: Field survey of DDT and HCH residues in ecosystem of the region 显示文摘 | Feng K Yu BY Ge D M | 2003 | Chemosphere2003，50，： | 1 |
| 14 | Current research in perineural invasion of cholangioeareinortm显示文摘 | SHEN FZ ZHANG BY FENG YJ | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 15 | Current research in perineural invasion of cholangiocarcinoma 显示文摘 | Shen FZ Zhang BY Feng YJ | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 16 | DeteImination of residual stresses in thick-section weldments 显示文摘 | SHIM BY Y FENG Z LEE S etc | 1992 | Welding Research1992，，9： | 1 |
| 17 | Evaluation of hepatoprotective effect of Zhi-Zi-Da-I-Iuang decoction and its two fractions against acute alcohol-induced liv- er injury in rats 显示文摘 | Wang H Feng F Zhuang BY | 2009 | J Ethnopharmacol2009，126，2： | 1 |
| 18 | Protective effects of vasonatrin pep- tide against hypobaric hypoxia-induced pulmonary hypertension in rats显示文摘 | Yu J Feng HS Chen BY | 2010 | Clin Exp Pharmacol Physiol2010，37，1： | 1 |
| 19 | Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea显示文摘 | Feng J Zhang D Chen BY | 2012 | Sleep Breath2012，16，2： | 1 |
| 20 | Inflammation status of rabbit carotid artery model endothelium during intermittent hypoxia exposure and its relationship with leptin 显示文摘 | Feng J Chen BY Cui LY | 2009 | Sleep Breath2009，13，3： | 1 |
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