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| 1 | 肝癌乙型肝炎病毒X抗原相关基因的克隆显示文摘目的 观察HepG2细胞因乙型肝炎病毒X抗原 (HBx)转染导致的基因表达差异。 方法①用逆转录病毒感染的方法建立表达乙型肝炎病毒X抗原 (HepG2X)及氯霉素乙酰转移酶 (HepG2Cat)的细胞模型。②用抑制差减杂交的方法做HepG2X和对照细胞 (HepG2Cat)的cDNA文库差示筛选。③用3 2 P随机引物标记法标记探针做NorthernBlot杂交及地高辛缺口翻译标记法做原位分子杂交以筛选基因探针。结果 经cDNA文库差减杂交及抑制性PCR扩增共得到 10个cDNA探针 ,其中 8个被HBx所启动 ,2个因HBx而表达下降。经检测 ,这些基因在HepG2X和对照细胞中的表达均有差异。在被HBx所抑制的 2个差示表达基因中 ,1个与人的蛋白翻译起始因子同源 ,同时发现 ,此基因在正常组织中表达较强 ,而在肿瘤组织中表达被抑制。结论 HBx能够改变宿主细胞的基因表达 。 | 刘杰 LIAN Zhaorui PAN Jinbo Clayton M 胡家露 朱明华 窦科峰 丁杰 吴开春 樊代明 Feitelson M | 2000 | 中华消化杂志2000，20，3： | 7 |
| 2 | Hepatitis B X antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma 显示文摘 | Feitelson MA Zhu M Duan LX | 1993 | Oncogene1993，8，5： | 1 |
| 3 | Interaction between alcohol and hepatitis virus in the liver显示文摘 | Brechot C Nalpas B Feitelson M A | | 0，，： | 1 |
| 4 | Early molecular and genetic determinants of primary liver malignancy显示文摘 | Feitelson M A Pan J B Lian Z R | 2004 | Surg Clin N Am2004，84，： | 1 |
| 5 | Transient inhibition of Th1-type cytokine production by CD4 T cells in hepatitis B core antigen immunized mice is mediated by regulatory T cells 显示文摘 | Chichester J A Feitelson M A Calkins C E | 2006 | Immunology2006，118，4： | 1 |
| 6 | Hepatitis B virus X antigen promotes transforming growth factor-betal (TGF-beta1) activity by upregulation of TGF-beta1 and down-regulation of alpha2-macroglobulin 显示文摘 | Pan J Clayton M Feitelson MA | 2004 | J Gen Virol2004，85，2： | 1 |
| 7 | Hepatitis B virus X antigenpromotes transforming growth factor-betal (T-GF-betal) activity byup regulation of TGF- betal and down regulation of alpha2-macroglobulin显示文摘 | Pan J Clayton M Feitelson MA | 2004 | J Gen Virol2004，852，： | 1 |
| 8 | Genetic mechanisms of hepatocarcinogenesis显示文摘 | Feitelson M A Sun B Tufan N L S | 2002 | Oncogene2002，21，： | 1 |
| 9 | Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis显示文摘 | Feitelson M A LeeJ | 2007 | Cancer Lett2007，252，2： | 1 |
| 10 | Hepatitis B virus X antigen promotes transforming growth factor-betal (TGF-beta1) activity by up-regulation of TGF-betal and down-regulation of alpha2-macroglobulin 显示文摘 | Pan J Clayton M Feitelson MA | 2004 | J Gen Virol2004，85，2： | 1 |
| 11 | Hepatitis B virus X antigen promotes transforming growth factor -bl (TGF -bl } activity by up -regulation of TGF -bl and down -regulation of a2 -macro- globulin显示文摘 | Pan JB Clayton M Feitelson MA | 2004 | J Gen Virol2004，85，2： | 1 |
| 12 | Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis显示文摘 | Feitelson M A Reis H M Liu J | 2005 | Front Biosci2005，10，： | 1 |
| 13 | Hepatitis B virus infection and primary hepatocellular carcinoma显示文摘 | | 1992 | Clin Microbiol Rev1992，5，： | 1 |
| 14 | Different response requirements for IFN-γ production in ELISPOT assays by CD4^+ T cells from mice early and late after immunization 显示文摘 | Chichester J A Feitelson M A Calkins C E | 2006 | J Immunol Metho2006，309，12： | 1 |
| 15 | Genetic mechanisms of hepatocarcinogenesis 显示文摘 | FEITELSON M A SUN B LIU J | 2002 | Oncogene2002，21，2： | 1 |
| 16 | Hepatitis B X antigen in hepatitis B virus carrer patients with liver cancer显示文摘 | Wang W L London W T Feitelson M A | 1997 | Cancer Res1997，51，18： | 1 |
| 17 | Integrity of p53in hepatitis B x antigen - positive and - negative hepatocellular carcinomas 显示文摘 | Feitelson MA Zhu M | 1997 | Cancer Res1997，57，： | 1 |
| 18 | The potential of a GISbased scoping system:An Israel proposal and case study显示文摘 | Haklay M Feitelson E Doytsher Y | 1998 | Environmental Impact Assessment Review1998，18，5： | 1 |
| 19 | Integrity of p53 in hepatitis B x antigen-positive and-negative hepatocellular carcinomas显示文摘 | Greenblatt MS Feitelson MA Zhu M | 1997 | Cancer Res1997，57，3： | 1 |
| 20 | Hepatitis B virus integration,fragile sites and hepatocareinogenesis显示文摘 | Feitelson M A Lee J | 2007 | Caneer Lett2007，252，2： | 1 |
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