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| 1 | Coagulopathy and transfusion therapy in pediatric livertransplantation显示文摘Bleeding and coagulopathy are critical issues complicating pediatric liver transplantation and contributing to morbidity and mortality in the cirrhotic child. The complexity of coagulopathy in the pediatric patient is illustrated by the interaction between three basic models. The first model, 'developmental hemostasis', demonstrates how a different balance between pro- and anticoagulation factors leads to a normal hemostatic capacity in the pediatric patient at various ages. The second, the 'cell based model of coagulation', takes into account the interaction between plasma proteins and cells. In the last, the concept of 'rebalanced coagulation' highlights how the reduction of both pro- and anticoagulation factors leads to a normal, although unstable, coagulation profile. This new concept has led to the development of novel techniques used to analyze the coagulation capacity of whole blood for all patients. For example, viscoelastic methodologies are increasingly used on adult patients to test hemostatic capacity and to guide transfusion protocols. However, results are often confounding or have limited impact on morbidity and mortality. Moreover, data from pediatric patients remain inadequate. In addition, several interventions have been proposed to limit blood loss during transplantation, including the use of antifibrinolytic drugs and surgical techniques, such as the piggyback and lowering the central venous pressure during the hepatic dissection phase. The rationale for the use of these interventions is quite solid and has led to their incorporation into clinical practice; yet few of them have been rigorously tested in adults, let alone in children. Finally, the postoperative period in pediatric cohorts of patients has been characterized by an enhanced risk of hepatic vessel thrombosis. Thrombosis in fact remains the primary cause of early graft failure and re-transplantation within the first 30 d following surgery, and it occurs despite prolongation of standard coagulation assays. Data, however, are currently lacking regarding the use of anti-aggregation/anticoagulation therapies and how to best monitor for thrombosis in the early postoperative period in pediatric patients. Therefore, further studies are necessary to elucidate the interaction between the development of the coagulation system and cirrhosis in children. Moreover, strategies to optimize blood transfusion and anticoagulation must be tested specifically in pediatric patients. In conclusion, data from the adult world can be translated with difficulty into the pediatric field as indication for transplantation, baseline pathologies and levels of pro- and anticoagulation factors are not comparable between the two populations. | Mirco Nacoti Davide Corbella Francesco Fazzi Francesca Rapido Ezio Bonanomi | 2016 | World Journal of Gastroenterology2016，22，6： | 5 |
| 2 | Human-centrie connectivity enabled by body-coupled communications 显示文摘 | Baldus H Corroy S Fazzi A | 2009 | IEEE Commun Mag2009，47，6： | 1 |
| 3 | Interstitial lung fibro- sis and rheumatic disorders in patients with hepatitis C virus infection显示文摘 | Ferri C La Civita L Fazzi P | 1997 | Br J Rheumatol1997，36，3： | 1 |
| 4 | Cerebral visual impairment in PVL:MR correlation显示文摘 | UGGETTI C EGITTO MG FAZZI E | 1996 | AJNR1996，17，5： | 1 |
| 5 | Effects of low day 3 Lu teinizing hormone levels on in vitro feritilization treatment outcome显示文摘 | Noci I Maggi M Fazzi B | 2000 | Gynecol Endocrinol2000，14，5： | 1 |
| 6 | Visual-perceptual impairment in children with periventricular leukomalacia显示文摘 | Fazzi E Bova SM Uggetti C | 2004 | Brain Dev2004，26，8： | 1 |
| 7 | In vivo studies on possible adverse effects on reproduction of the fungicide methyl thiophanate显示文摘 | Traina M E Fazzi P Macrl C | | Appl Toxicol0，18，： | 1 |
| 8 | 显示文摘 | Fazzi R Galimberti S Testi R | 2002 | Leuk Res2002，26，9： | 1 |
| 9 | Early interven- tion in visually impaired children显示文摘 | Fazzi E Signorini SG Bova SM | 2005 | International Con gress Series2005，128，2： | 1 |
| 10 | Local anaesthetic infusion with elastomeric pump after arthroscopic subacromial decompression显示文摘 | Little K Pillai A Fazzi U | 2007 | Ann R Coll Surg Engl2007，89，4： | 1 |
| 11 | Neuro-ophthalmo- logical disorders in cerebral palsy: ophthalmological, oculo- motor, and visual aspects显示文摘 | Fazzi E Signorini SG LA Piana R | 2012 | Dev Med Child Neurol2012，54，8： | 1 |
| 12 | Cognitive visual dys- function,; in preterm children with periventricular leukomala- cia 显示文摘 | Fazzi E Bova S Giovenzana A | 2009 | Dev Med Child Neurol2009，51，12： | 1 |
| 13 | Biomechanical analysis of locked and non-locked plate fixation of the clavicle显示文摘 | Little KJ Riches PE Fazzi UG | 2012 | Injury2012，43，6： | 1 |
| 14 | Adenosine receptor targeting in health and disease 显示文摘 | Gessi S Merighi S Fazzi D | 2011 | Expert Opin Investig Drugs2011，20，12： | 1 |
| 15 | Early morbidity and neurodevelopmental outcome in low-birth weight infants born after third trimester bleeding显示文摘 | Spinillo A Fazzi E Stronati M | 1994 | Am J Perinatal1994，11，2： | 1 |
| 16 | The influence of anxiety on qua- lity of life among patients with an indication for cataract surgery显示文摘 | Fazzi L Dobrianskyj FM Reggi JR | 2015 | Sao Paulo Med J2015，133，2： | 1 |
| 17 | Mutations involved in Aicardi-Gouti6res syndrome implicate SAMHD1 as regulator of the innate immune response显示文摘 | Rice GI Bond J Asipu A Brunette R L Manfield I W Cart I M Fuller J C Jackson R M Lamb T Briggs TA Ali M Gornall H Couthard L R Aeby A Attard-Montalto S P Bertini E Bodemer C Brockmann K Brueton L A Corry P C Desguerre I Fazzi E Cazorla A G Gener B Hamel B C Heiberg A Hunter M van der Knaap M S Kumar R Lagae L Landrieu P G Lourenco C M Marom D McDer- mott M F van der Merwe W Orcesi S Prendiville J S Rasmussen M Shalev S A Soler D M Shinawi M Spiegel R Tan T Y Vanderver A Wakeling EL Wassmer E Whittaker E Lebon P Stetson D B Bonthron D T Crow Y J | 2009 | Nature Genetics2009，41，： | 1 |
| 18 | Leber' s congenital amaurosis: an update显示文摘 | Fazzi E Signorini SG Scelsa B | 2003 | Eur J Paediatr Neurol2003，7，1： | 1 |
| 19 | A questionnaire onsleep behaviour in the first years of life: preliminary resultsfrom a normative sample 显示文摘 | Fazzi E Zaccagnino M Capsoni C | 2006 | Fund Neurol2006，21，3： | 1 |
| 20 | Smooth muscle cell changes during flow-related remodeling of rat mesenteric resistance arteries显示文摘 | BUUS C L POURAGEAUD F FAZZI G E | | 0，，： | 1 |
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